DRSC/TRiP Functional Genomics Resources

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Protein Alignment MstProx and Tlr4

DIOPT Version :9

Sequence 1:NP_649719.2 Gene:MstProx / 40890 FlyBaseID:FBgn0015770 Length:965 Species:Drosophila melanogaster
Sequence 2:NP_067272.1 Gene:Tlr4 / 21898 MGIID:96824 Length:835 Species:Mus musculus


Alignment Length:927 Identity:188/927 - (20%)
Similarity:354/927 - (38%) Gaps:253/927 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   138 LNEIIEYINKTT--------DNVNEIIINAYKTVENQQIALDNLIFNGKSHLRSLTFIGF----- 189
            ||..||.:...|        ..|.:.|.::.|.::        |.||....|:|.:|..|     
Mouse    25 LNPCIEVVPNITYQCMDQKLSKVPDDIPSSTKNID--------LSFNPLKILKSYSFSNFSELQW 81

  Fly   190 ------QIENLSTKPFAQFINLKRMVLTN--------------CTVRNLTFLRTLQKSLEHLELD 234
                  :||.:..|.:....:|..::||.              .::.||..:.|...|||  ...
Mouse    82 LDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGSFSGLTSLENLVAVETKLASLE--SFP 144

  Fly   235 IDNEVDLKYFTNFSSLKFMKVRNYIPN-------KNFTALICTHKNCNFIRGI--NGLECPKLCQ 290
            |...:.||        |.....|:|.:       .|.|.|:....:.|:|:.|  |.|:      
Mouse   145 IGQLITLK--------KLNVAHNFIHSCKLPAYFSNLTNLVHVDLSYNYIQTITVNDLQ------ 195

  Fly   291 CLYIIDDLELNIDCSNLGLLQIPPLPIPSYGGVKL-------NFSNNSLSQLPTMTLPG------ 342
              ::.::.::|:.. ::.|..|..:...::.|:||       ||:::::.:.....|.|      
Mouse   196 --FLRENPQVNLSL-DMSLNPIDFIQDQAFQGIKLHELTLRGNFNSSNIMKTCLQNLAGLHVHRL 257

  Fly   343 ----YKLVKRLDVSR----NRLTNLSIN--HLPAKLDYLD--VSFNEIIN-----MGNDVIKYLR 390
                :|..:.|::..    ..|.:::|:  .|....|:.|  |.|:.:.|     :....||||.
Mouse   258 ILGEFKDERNLEIFEPSIMEGLCDVTIDEFRLTYTNDFSDDIVKFHCLANVSAMSLAGVSIKYLE 322

  Fly   391 TVPIFKQTGNQWTIHCDDK--PLLN--FFRHLKLIIRMKSAEMKPMFLHSLT--ELPKGFLKFLG 449
            .||...:..:...|.|..|  |.|:  |.:.|.|.:...|...|.:.|.||:  :|.:..|.|.|
Mouse   323 DVPKHFKWQSLSIIRCQLKQFPTLDLPFLKSLTLTMNKGSISFKKVALPSLSYLDLSRNALSFSG 387

  Fly   450 KHFIWLGVRKQEYYLINEEQLLQSMHRKLNNLNTIMSIYKYMEWLHRKLIFVNREYDLFYIRQMA 514
                                                                             
Mouse   388 ----------------------------------------------------------------- 387

  Fly   515 APCPHKCECCYSRDSLILKIDCRNKFVYNFPDIVARNSRLMGKQNMSSPMELHLSKNNISNITIA 579
                    ||...|   |..:.......:|...:..::..||.:.:......|.:...::..:..
Mouse   388 --------CCSYSD---LGTNSLRHLDLSFNGAIIMSANFMGLEELQHLDFQHSTLKRVTEFSAF 441

  Fly   580 MLPKELRFLDLRFNNL-VTLDDKVLSYLKKNSIKTKLSGNPWNCDCKSRSVLSILRDHEPLEYDV 643
            :..::|.:||:.:.|. :..|...|.....|::  |::||.:.                    |.
Mouse   442 LSLEKLLYLDISYTNTKIDFDGIFLGLTSLNTL--KMAGNSFK--------------------DN 484

  Fly   644 TLKRCNISPTDCP--DVCVCCLDNLTWPSFIVDCRGEGLLQMPSLS-SRVTYVDLRN-NNLTALS 704
            ||.....:.|:..  |:..|.|:.::|..|....|    ||:.::| :.:.::|..: |.|.:||
Mouse   485 TLSNVFANTTNLTFLDLSKCQLEQISWGVFDTLHR----LQLLNMSHNNLLFLDSSHYNQLYSLS 545

  Fly   705 ---------QKNRSSIEN--RSLK-LHLLDNPWSCSCNDIEKINFMKSVSSSIVDFTEIKCSNGE 757
                     :.::..:::  :||. .:|.:|..:|.|...:.:.::|.....:|:..::.|:.. 
Mouse   546 TLDCSFNRIETSKGILQHFPKSLAFFNLTNNSVACICEHQKFLQWVKEQKQFLVNVEQMTCATP- 609

  Fly   758 KLVSINQHIVCPSD----LFYYLALAISLVATII--ALNFLIWFRQPVLVWFYEHGVCLSLSAKR 816
              |.:|..:|...:    ..|...:::|:|:.|:  .:.|||:.       ||.| :.|....|:
Mouse   610 --VEMNTSLVLDFNNSTCYMYKTIISVSVVSVIVVSTVAFLIYH-------FYFH-LILIAGCKK 664

  Fly   817 ELDKDKRFDAFLAFTHKDEA-LLEEFVDRLERGRPRFQLCFYLRDWLAGESI-PDCIGQSIKDSR 879
            ....:..:|||:.::.::|. :..|.|..||.|.|||.||.:.||::.|.:| .:.|.:....||
Mouse   665 YSRGESIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIQEGFHKSR 729

  Fly   880 RIIVLMTENFMNSTWGRLEFRLA---LHATSRDRCKRLIVVLYPNVKNFDSLDSELRTYMAFNTY 941
            ::||:::.:|:.|.|...|:.:|   ...:||...  :.:||....|:......||...::.|||
Mouse   730 KVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGI--IFIVLEKVEKSLLRQQVELYRLLSRNTY 792

  Fly   942 LE-RSHP----NFWNKL 953
            || ..:|    .||.:|
Mouse   793 LEWEDNPLGRHIFWRRL 809

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MstProxNP_649719.2 leucine-rich repeat 325..345 CDD:275378 5/36 (14%)
leucine-rich repeat 346..367 CDD:275378 4/26 (15%)
leucine-rich repeat 563..583 CDD:275378 1/19 (5%)
leucine-rich repeat 585..610 CDD:275378 6/25 (24%)
leucine-rich repeat 611..622 CDD:275378 3/10 (30%)
TIR 823..960 CDD:214587 44/141 (31%)
Tlr4NP_067272.1 LRR_8 53..113 CDD:290566 14/67 (21%)
LRR 1 54..75 7/28 (25%)
leucine-rich repeat 58..78 CDD:275380 7/27 (26%)
LRR 2 78..99 3/20 (15%)
leucine-rich repeat 79..102 CDD:275380 3/22 (14%)
LRR 3 102..123 3/20 (15%)
leucine-rich repeat 103..126 CDD:275380 3/22 (14%)
LRR 4 126..147 7/22 (32%)
leucine-rich repeat 127..150 CDD:275380 7/24 (29%)
LRR_8 150..214 CDD:290566 15/80 (19%)
LRR 5 150..171 5/28 (18%)
leucine-rich repeat 151..175 CDD:275380 6/31 (19%)
LRR 6 175..198 6/30 (20%)
leucine-rich repeat 176..204 CDD:275380 6/35 (17%)
LRR 7 204..224 3/20 (15%)
leucine-rich repeat 205..226 CDD:275380 3/21 (14%)
LRR 8 226..247 4/20 (20%)
LRR 9 248..269 3/20 (15%)
LRR 10 329..349 5/19 (26%)
leucine-rich repeat 331..350 CDD:275380 5/18 (28%)
LRR 11 350..370 5/19 (26%)
leucine-rich repeat 351..372 CDD:275380 5/20 (25%)
LRR_RI <369..555 CDD:238064 43/287 (15%)
LRR 12 372..392 8/92 (9%)
leucine-rich repeat 373..398 CDD:275380 9/100 (9%)
LRR 13 398..420 3/21 (14%)
leucine-rich repeat 399..421 CDD:275380 3/21 (14%)
LRR 14 421..442 1/20 (5%)
leucine-rich repeat 422..446 CDD:275380 1/23 (4%)
LRR 15 446..467 5/20 (25%)
leucine-rich repeat 447..470 CDD:275380 6/22 (27%)
LRR 16 470..490 7/41 (17%)
leucine-rich repeat 471..495 CDD:275380 7/45 (16%)
LRR_8 494..554 CDD:290566 15/63 (24%)
LRR 17 495..516 5/20 (25%)
leucine-rich repeat 496..519 CDD:275380 5/22 (23%)
LRR 18 519..540 5/24 (21%)
leucine-rich repeat 520..543 CDD:275380 6/22 (27%)
LRR 19 543..564 2/20 (10%)
Interaction with SCIMP. /evidence=ECO:0000269|PubMed:28098138 670..835 44/142 (31%)
TIR 672..813 CDD:214587 44/140 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24365
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.920

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