DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MstProx and Tlr1

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_001263374.1	Gene:	Tlr1 / 21897	MGIID:	1341295	Length:	795	Species:	Mus musculus

Alignment Length:	847	Identity:	187/847 - (22%)
Similarity:	326/847 - (38%)	Gaps:	249/847 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 CNFIRGINGLECPKLCQCLYIIDDLELNIDCSNLGLLQIP-PLPIPSYGGVKLNFSNNSLSQLPT 337
            |..:.|:..::       :.:.::.||.|...|..|.::| .||:.:   ..|:.|.|::|:|.|
Mouse    11 CIIVLGLTLMK-------IQLSEECELIIKRPNANLTRVPKDLPLQT---TTLDLSQNNISELQT 65

  Fly   338 MTLPGYKLVKRLDVSRNRL--TNLSINHLPAKLDYLDVSFNE---IINMGNDVIKYL-------R 390
            ..:.....::.|.:|.|||  .|:|:.....:|:|||:|.||   |:......:|:|       .
Mouse    66 SDILSLSKLRVLIMSYNRLQYLNISVFKFNTELEYLDLSHNELKVILCHPTVSLKHLDLSFNAFD 130

  Fly   391 TVPIFKQTGN-------------------QWTIHCD-DKPLL------------NFFRH------ 417
            .:||.|:.||                   |...|.: .|.||            ...||
Mouse   131 ALPICKEFGNMSQLQFLGLSGSRVQSSSVQLIAHLNISKVLLVLGDAYGEKEDPESLRHVSTETL 195

  Fly   418 -----------------LKLIIRMKSAEMK--------PMFLHSLTELPK--------------- 442
                             :...|.::.:.:|        ..||.:|::|.|
Mouse   196 HIVFPSKREFRFLLDVSVSTTIGLELSNIKCVLEDQGCSYFLRALSKLGKNLKLSNLTLNNVETT 260

  Fly   443 --GFLKFLGKHFIWLGVRKQEYYLINEEQL-----------------LQSMHRKLNNLNTIMSIY 488
              .|:..|  ..:|....|  |:.|:..:|                 ..|:|:.:.::.:....|
Mouse   261 WNSFINIL--QIVWHTPVK--YFSISNVKLQGQLAFRMFNYSDTSLKALSIHQVVTDVFSFPQSY 321

  Fly   489 KYMEWLHRKLIFVNREYDLFYIRQMAAPCPHKCE-CCYSRDSLILKIDCRNKFVYNFPDIVARNS 552
            .|.       ||.|..     |:.......|... .|.|:.|..|.:|..:..:   .|:|.::.
Mouse   322 IYS-------IFANMN-----IQNFTMSGTHMVHMLCPSQVSPFLHVDFTDNLL---TDMVFKDC 371

  Fly   553 RLMGKQNMSSPMELHLSKNNISNITIAMLPK----ELRFLDLRFNNLVTLDDKV-----LSYLKK 608
            |     |:.....|.|.||.:.|:...:|..    .|:.||:..|:|...|..:     .|.|..
Mouse   372 R-----NLVRLKTLSLQKNQLKNLENIILTSAKMTSLQKLDISQNSLRYSDGGIPCAWTQSLLVL 431

  Fly   609 NSIKTKLSGNPWNC--------DCKSRSVLSILRDHEPLEYDVTLKRCNI---SPTDCPDVCVCC 662
            |.....|:|:.:.|        |..:..::||.:|...|:   .|:..|:   |.||.|
Mouse   432 NLSSNMLTGSVFRCLPPKVKVLDLHNNRIMSIPKDVTHLQ---ALQELNVASNSLTDLP------ 487

  Fly   663 LDNLTWPSFIVDCRGEGLLQMPSLSSRVTYVDLRNNNLTALSQKNRSSIEN-RSLKLHLLDNPWS 726
                            |.....|||  |..:|  :|:::..|:....|.:| |||...  :||:.
Mouse   488 ----------------GCGAFSSLS--VLVID--HNSVSHPSEDFFQSCQNIRSLTAG--NNPFQ 530

  Fly   727 CSCNDIEKINFMKS---VSSSIV---------DFTEIKCSNGEKLVSINQH-IVCPSDLFYYLAL 778
            |:|   |..:|:|:   |:..:|         |:.|  .|.|..|...:.. :.|.:.|     |
Mouse   531 CTC---ELRDFVKNIGWVAREVVEGWPDSYRCDYPE--SSRGTALRDFHMSPLSCDTVL-----L 585

  Fly   779 AISLVATIIAL----NFL-IWFRQPVLVWFYEHGVCLSLSAK--------RELDKDKRFDAFLAF 830
            .:::.||::.|    .|| ::|..|   | |...:|.....:        .||.::.:|.||:::
Mouse   586 TVTIGATMLVLAVTGAFLCLYFDLP---W-YVRMLCQWTQTRHRARHIPLEELQRNLQFHAFVSY 646

  Fly   831 THKDEALLE-EFVDRLERGRPRFQLCFYLRDWLAGESIPDCIGQSIKDSRRIIVLMTENFMNSTW 894
            :..|.|.:: |.:..||  :...|:|.:.|:::.|:||.:.|...|:.|.:.|.:::.:|:.|.|
Mouse   647 SGHDSAWVKNELLPNLE--KDDIQICLHERNFVPGKSIVENIINFIEKSYKSIFVLSPHFIQSEW 709

  Fly   895 GRLEFRLALHATSRDRCKRLIVVLYPNVKNFDSLDS---ELRTYMAFNTYLE-----RSHPNFWN 951
            ...|...|.|....:....||::|...:..: |:.:   :|:|.|:..||||     ..|..||.
Mouse   710 CHYELYFAHHNLFHEGSDNLILILLAPIPQY-SIPTNYHKLKTLMSRRTYLEWPTEKNKHGLFWA 773

  Fly   952 KL 953
            .|
Mouse   774 NL 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	6/19 (32%)
		leucine-rich repeat	346..367	CDD:275378	7/22 (32%)
		leucine-rich repeat	563..583	CDD:275378	6/19 (32%)
		leucine-rich repeat	585..610	CDD:275378	8/29 (28%)
		leucine-rich repeat	611..622	CDD:275378	2/10 (20%)
		TIR	823..960	CDD:214587	39/140 (28%)
Tlr1	NP_001263374.1	PRK15370	<38..>133	CDD:185268	27/97 (28%)
		LRR	<48..317	CDD:227223	51/275 (19%)
		leucine-rich repeat	50..73	CDD:275378	6/25 (24%)
		LRR 1	54..77		5/22 (23%)
		leucine-rich repeat	74..97	CDD:275378	7/22 (32%)
		LRR 2	78..101		7/22 (32%)
		leucine-rich repeat	98..118	CDD:275378	8/19 (42%)
		LRR 3	102..125		7/22 (32%)
		leucine-rich repeat	119..143	CDD:275378	7/23 (30%)
		LRR 4	126..150		5/23 (22%)
		leucine-rich repeat	144..156	CDD:275378	0/11 (0%)
		LRR 5	151..175		5/23 (22%)
		LRR 6	176..199		2/22 (9%)
		LRR 7	200..223		1/22 (5%)
		LRR 8	224..250		6/25 (24%)
		LRR 9	251..278		4/30 (13%)
		LRR 10	279..308		3/28 (11%)
		LRR 11	309..337		6/39 (15%)
		Interaction with bacterial lipopeptide. /evidence=ECO:0000250	316..319		0/2 (0%)
		LRR 12	338..361		6/22 (27%)
		leucine-rich repeat	355..376	CDD:275380	5/28 (18%)
		LRR 13	362..388		8/33 (24%)
		PRK15370	<377..>487	CDD:185268	28/112 (25%)
		leucine-rich repeat	377..402	CDD:275380	6/24 (25%)
		LRR 14	389..414		6/24 (25%)
		leucine-rich repeat	403..427	CDD:275380	6/23 (26%)
		LRR 15	415..437		4/21 (19%)
		leucine-rich repeat	428..449	CDD:275380	5/20 (25%)
		LRR 16	438..457		4/18 (22%)
		leucine-rich repeat	450..472	CDD:275380	5/24 (21%)
		LRR 17	458..478		5/22 (23%)
		leucine-rich repeat	473..494	CDD:275380	7/42 (17%)
		LRR 18	479..500		9/44 (20%)
		leucine-rich repeat	495..518	CDD:275380	7/26 (27%)
		LRR 19	501..524		8/24 (33%)
		LRRCT	527..581	CDD:214507	14/58 (24%)
		TIR	639..782	CDD:214587	39/140 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920