DRSC/TRiP Functional Genomics Resources

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Protein Alignment MstProx and tol-1

DIOPT Version :10

Sequence 1:NP_649719.2 Gene:MstProx / 40890 FlyBaseID:FBgn0015770 Length:965 Species:Drosophila melanogaster
Sequence 2:NP_001020983.1 Gene:tol-1 / 171635 WormBaseID:WBGene00006593 Length:1221 Species:Caenorhabditis elegans


Alignment Length:1193 Identity:237/1193 - (19%)
Similarity:419/1193 - (35%) Gaps:411/1193 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   141 IIEYINKTTDNVNEIIINAYKTVENQQ---IALDN-------LIFNGKSHLRSLTFIGFQIENLS 195
            :.:|.:|.| .:..|..:.|..|.|.:   |:.||       ..|...:.|..|..:|.:..:.|
 Worm    47 LCDYSSKNT-TITPIASSNYDQVANIRSLFISCDNNNFQFPDAYFKSLTALHHLRIVGCETTHFS 110

  Fly   196 TKPFAQFINLKRMVLTNCTVRNLTF------LRTLQKSLEHLELDIDNEVDLKYFTNFSSLKFMK 254
            .|.|.....|:|:.|...:..:.:|      |..|.: ||...|.....::|.. ....||..::
 Worm   111 VKLFEDLAALRRLELDQISTASTSFEMTEDVLMPLAR-LEKFSLTRSRNIELPQ-RLLCSLPHLQ 173

  Fly   255 VRNYIPNKNFTALICTHKNC-------------------NFIRGINGLECPKLCQCLYIIDDLEL 300
            |.|.  :.|....:...::|                   .|:|||..:.  ::......|.:|:|
 Worm   174 VLNI--SSNELPSLRREESCVAQQLLIVDLSRNRLTNIEQFLRGIPAIR--QISVAYNSIAELDL 234

  Fly   301 N--------IDCSNLGLLQIPPLPIPSYGG--VKLNFSNNSLSQLPTMTLPGYKLVKRLDVSRNR 355
            :        :|.....::.:..||     |  |.:|.:.|:|.::|........|| .|:||||.
 Worm   235 SLATPFLQQLDAEANRIVDLTSLP-----GTVVHVNLAGNALKRVPDAVAELASLV-ALNVSRNE 293

  Fly   356 LT--NLSINHLPAKLDYLDVSFNEI-----------------INMGNDVIKYLRTVPIFKQTGNQ 401
            :.  |.|:...| :|:.||.|:|::                 :::.::.|:.| |..:.....|.
 Worm   294 IEAGNSSVFSSP-ELEMLDASYNKLDSLPVEWLQKCEKRIAHLHLEHNSIEQL-TGGVLANATNL 356

  Fly   402 WTIHCDDKPLLNFFR------------------HLKLI-------IRMKSAEMKPMFLHSLTELP 441
            .|:...... |..||                  .|:|:       ::::|.::..   :.|||:|
 Worm   357 QTLDLSSNQ-LRVFRDEVLPENSKIGNLRLSNNSLELLEPSSLSGLKLESLDLSH---NKLTEVP 417

  Fly   442 KGFLKFLGKHFIWLG---VRKQEYYLINEEQLLQSMHRKLNNLNTI-MSIYKYMEWLHRKLIFVN 502
            ....|......:.|.   :.|...|::|:.:.|.::....|.|.:| ..|:.....|| .|...|
 Worm   418 AAIGKVEQLKKVDLSHNRIAKVYQYVLNKIKQLHTVDLSNNQLQSIGPYIFSDSSELH-SLDVSN 481

  Fly   503 REYDLFYIRQMAAPCPH------KCECCYSRD------SLILKID-CRNKFVYNFPDIVARNSRL 554
            .|..|.: :...|.||.      |.....|.|      |.:.::| ..|:.:......:..|..:
 Worm   482 NEISLLF-KDAFARCPKLRKISMKMNKIKSLDEGLTEASGLRRLDVSHNEILVLKWSALPENLEI 545

  Fly   555 MGKQN---------MSSPMELHLSKNNISN--ITIA---MLPKELRFLDLRFNNLVTLDDKVL-- 603
            :...|         ..||...:|...::||  |||.   .:|..|..||:..|.|..|....|  
 Worm   546 LNADNNDINLLTAASMSPSTANLKSVSLSNNGITIMNADQIPNSLESLDVSNNRLAKLGKTALAA 610

  Fly   604 -SYLKK----------------------NSIKTKLSGNPWNCDCKSRSVLS------ILRDHEPL 639
             |.|::                      :.:|.::|.||..|||:...::.      :::|.|..
 Worm   611 KSQLRRLNLKGNLLTVVATESMKVVEAVHPLKVEISENPLICDCQMGWMIGGAKPKVLIQDSETA 675

  Fly   640 E-------YDVTLKRCNISPTD--------CPDVCVCC--------------------------- 662
            .       :.:.::  ::|..|        |...|:||                           
 Worm   676 SCSHAVDGHQIQIQ--SLSKKDLLCPYKSVCEPECICCQYGNCDCKSVCPANCRCFRDDQFNINI 738

  Fly   663 ----------------------------LDNLTWP-----SFI-------VDCRGEGLLQ----- 682
                                        |..:|.|     |||       :...|.||..     
 Worm   739 VRCHGNSSMVPKREFVVSELPVSATEIILSGVTLPQLRTHSFIGRLRLQRLHINGTGLRSIQPKA 803

  Fly   683 ---MPSLSSRVTYVDLRNNNLTALSQK---------------NRSS-----------------IE 712
               :|:|.:    :||.:|:|.:||.:               ||.|                 :.
 Worm   804 FHTLPALKT----LDLSDNSLISLSGEEFLKCGEVSQLFLNGNRFSTLSRGIFEKLPNLKYLTLH 864

  Fly   713 NRSL-------------KLHLLDNPWSCSCN-----------DIEKINFMKSVSSS--------I 745
            |.||             |:.|..||..|.|:           |.:...|.:..::.        :
 Worm   865 NNSLEDIPQVLHSTALSKISLSSNPLRCDCSGGSQQHLHHRRDPKAHPFWEHNAAEWFSLHRHLV 929

  Fly   746 VDFTEIKC---------SNGEKLVS---------------------INQHIVCP----------- 769
            |||.:::|         :|...::|                     .|..|..|           
 Worm   930 VDFPKVECWENVTKAFLTNDTTVLSAYPPNMGNDVFVMPIEEFLRDYNSTICVPFSSGFFGQDPQ 994

  Fly   770 -SDLFYYLALAISL---VATIIALNFLIWFRQPVLVWFYEHGVCLSLSAKRELDKDK------RF 824
             |.||..:.::|::   |..|:|::|:......:....|:   ..||:.........      .:
 Worm   995 NSILFVIITISIAVLLCVLVILAISFIRKSHDAINQRRYK---ASSLNCSTSAGSSPLPVPLLSY 1056

  Fly   825 DAFLAFTHKDEALLEEFVDRLERGRP----RFQLCFYLRDWLAG-------ESIPDCIGQSIKDS 878
            .||::::.|||.::   :|:|  .||    .:|||...||   |       .:|.|.:...:..|
 Worm  1057 HAFVSYSKKDEKMV---IDQL--CRPLEDEDYQLCLLHRD---GPTYCSNLHAISDELIAQMDSS 1113

  Fly   879 RRIIVLMTENFMNSTWGRLEFRLALHATSRDRCKRLIVVLYPNVKNFDSLDSELRTYMAFNTYLE 943
            :.:|:::|::|:.:.|..|:.:.:....:::|.||:|.||...| :.:.||.||...:..:|.:|
 Worm  1114 QCLILVLTKHFLENEWKTLQIKTSHQLFAKNRAKRVIAVLGDGV-DANLLDDELGQILRKHTRIE 1177

  Fly   944 -RSHPNFWNKLIYSMPL---LPS 962
             ||| .||..|..|:|.   |||
 Worm  1178 MRSH-LFWTLLHSSLPSRLPLPS 1199

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MstProxNP_649719.2 PRK15370 <315..>398 CDD:185268 26/103 (25%)
leucine-rich repeat 325..345 CDD:275378 4/19 (21%)
leucine-rich repeat 346..367 CDD:275378 9/22 (41%)
TIR 823..960 CDD:214587 44/151 (29%)
tol-1NP_001020983.1 leucine-rich repeat 71..95 CDD:275380 4/23 (17%)
leucine-rich repeat 96..119 CDD:275380 6/22 (27%)
leucine-rich repeat 120..171 CDD:275380 12/52 (23%)
PLN00113 <166..>460 CDD:215061 59/309 (19%)
leucine-rich repeat 172..195 CDD:275380 4/24 (17%)
leucine-rich repeat 196..283 CDD:275380 16/93 (17%)
leucine-rich repeat 219..240 CDD:275378 3/22 (14%)
leucine-rich repeat 241..258 CDD:275378 1/16 (6%)
leucine-rich repeat 287..306 CDD:275380 8/19 (42%)
leucine-rich repeat 307..331 CDD:275380 5/23 (22%)
leucine-rich repeat 332..355 CDD:275380 3/23 (13%)
LRR 337..653 CDD:443914 64/322 (20%)
leucine-rich repeat 356..379 CDD:275380 4/23 (17%)
leucine-rich repeat 380..395 CDD:275380 2/14 (14%)
leucine-rich repeat 403..425 CDD:275380 6/24 (25%)
leucine-rich repeat 426..449 CDD:275380 4/22 (18%)
leucine-rich repeat 450..473 CDD:275380 5/22 (23%)
leucine-rich repeat 474..497 CDD:275380 8/24 (33%)
leucine-rich repeat 498..520 CDD:275380 3/21 (14%)
leucine-rich repeat 543..567 CDD:275380 3/23 (13%)
leucine-rich repeat 568..589 CDD:275380 7/20 (35%)
leucine-rich repeat 590..613 CDD:275380 7/22 (32%)
leucine-rich repeat 614..633 CDD:275380 1/18 (6%)
leucine-rich repeat 763..785 CDD:275378 6/21 (29%)
LRR <779..>891 CDD:443914 24/115 (21%)
leucine-rich repeat 786..809 CDD:275378 3/22 (14%)
leucine-rich repeat 810..833 CDD:275378 7/26 (27%)
leucine-rich repeat 834..857 CDD:275378 3/22 (14%)
leucine-rich repeat 858..879 CDD:275378 3/20 (15%)
leucine-rich repeat 880..892 CDD:275378 4/11 (36%)
SEFIR 1056..1194 CDD:474043 44/147 (30%)

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