DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MstProx and LOC103911657

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	XP_009303036.2	Gene:	LOC103911657 / 103911657	-ID:	-	Length:	951	Species:	Danio rerio

Alignment Length:	1051	Identity:	223/1051 - (21%)
Similarity:	386/1051 - (36%)	Gaps:	316/1051 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 PISKENRLKLNELI---VSDTSYPIRAVDYLRQLGVETVTRFENQINSFKVIERDVHYINGPK-- 126
            |:...:..|||..:   |:|....::.:.             .|.:|.|..::...|.:..|.
Zfish    43 PVKASSASKLNITVCRSVTDIKEDLQGLP-------------ANLLNLFVHMDGGCHGVLAPNSF 94

  Fly   127 ----SLKIIIQSNLYLNEIIEYINKTTDNVNEIIINAYKTVEN-QQIALDNLIFNGKSHLRSLTF 186
                ||:.:..|..:.....|..|..| ||..:.| :|...|| .::|||      .|||.|||.
Zfish    95 SSFASLEQLTISGCFSEIPPEAFNGLT-NVTSLTI-SYNFSENCSKVALD------FSHLPSLTS 151

  Fly   187 IG---FQIENLSTKPFAQFINLKRMVLTNCTVRNLT-FLRTLQKSLEHLELDIDNEVDLKYFTNF 247
            :.   :.:..|::..|.....|:.::|.|..:|::: .|..|.|              :|...:|
Zfish   152 LSISDYSLSLLASNVFETIPLLQNLILANVCLRDMSEVLCRLSK--------------VKTLKHF 202

  Fly   248 SSLKFMKVRNYIPNKNFTALICTHKNCNFIRGINGLECPKLCQCLYIIDDLELNIDCSNL----- 307
            :..:|:..|...||       |:..|.:.|                   ..|.||:..||
Zfish   203 TLKEFLLKRLQYPN-------CSVFNTSDI-------------------STEFNIEEVNLHFATV 241

  Fly   308 -----GLLQIPPLPIPSYGGVKLN---FSNNSLSQLPTMTLPGYKLVKRLDVSRNRLTNLSINHL 364
                 |.|::       :|  ||:   ||.:|...|..::|.|...:|.||.
Zfish   242 EHVDEGALKV-------FG--KLSRFVFSVSSTDFLRDLSLIGVHKIKTLDF------------- 284

  Fly   365 PAKLDYLDV----SFNEIINMGNDVIKYLRTVPIFKQTGNQWTIH------C------------- 406
              |:|.|:|    :..::..:.:..:||        :|.|.|..|      |
Zfish   285 --KVDLLNVADLCTAAKLYGINSIQVKY--------KTTNFWPTHTNISGGCKNIKDVMLDTILY 339

  Fly   407 -----DDKPLLNFFRHLKLIIRMKSAEMKPMFLHSLTELPKGFLKFLGKHFIWLGVRKQEYYLIN 466
                 |...:...|.:|.:|...|.......|.......|:..     ||
Zfish   340 PANLLDVNCVFQIFSNLTIISIYKHVLRSDDFQTLCASFPQTV-----KH--------------- 384

  Fly   467 EEQLLQSMHRKLNNLNTIMSIYKYMEWLHRKLIFVNREYDLF----------------------Y 509
                |.:|..:|..::||:|        |:.:.|.|.|..:|                      .
Zfish   385 ----LSAMDLRLKKVDTIVS--------HQFMCFPNLETLIFTSSKIVVIEDFAFIGLNKLKELN 437

  Fly   510 IRQMAAPCPHKCECCYSRDSLILKIDCRNKFVY----NFPDIVARNSRLMGKQNM---SSPMELH 567
            :|:......|:.......:.|:|.:. .|..:|    :|......:|.|:|..|.   .|.::||
Zfish   438 LRKNKISSIHRHTFSGLHELLVLDLQ-ENPIIYIEPKSFGHFTNLSSLLLGDLNFPPNMSLIKLH 501

  Fly   568 LS------KNNISNITIAMLPKELRFLDLRFNNLVTLDDKVLSYLKKNSIKTKLSGNPWNCDCKS 626
            ||      .:|:||:.|:   ..||.:.|...:..||::.:..::|...:..:        ||.|
Zfish   502 LSDIFGGIPSNLSNVFIS---SGLRPMHLMIGSNTTLNNGLNLHIKGQYVIVE--------DCNS 555

  Fly   627 RSVLSILR----------------DHEP----LEYD-------------------VTLKRCNISP 652
            ..:.|:::                .:.|    ||:.                   .|||..||..
Zfish   556 LLLTSVVKLQIHAAYMSCENDFIGKYVPSVVSLEFQSMFSDNIGDLSVINQLFHLKTLKLRNIEF 620

  Fly   653 TDCPDVCVCCLDNLTWPSFIV--DCRGEGLLQMPSLSSRVTYVDLRNNNLTALSQKNRSSIENRS 715
            |:.|:..: ...|||....::  :||      :..|...:| .||:......||.|:..:|....
Zfish   621 TNQPNTGI-MFHNLTKLETLILSNCR------IFFLDGSLT-KDLKALTKLLLSAKHTVNILQSF 677

  Fly   716 LK-------LHLLDNPWSCSCNDIEKINFMK-----SVSSSIVDFTEIKCSNGEKLVSIN--QHI 766
            ::       :|:......|||::....:::|     .|..|......::|..|.:...:|  .::
Zfish   678 VEHLVHLEYIHIDSIDLYCSCDNAWLFSWVKDNRKVEVVVSNPSMQNLQCFIGNEFDQLNFVSYV 742

  Fly   767 V--CPSDLFYYLALAISL-----VATIIALNFLIWFRQPVL----VWFYEHGVCLSLSAKRELDK 820
            .  |..||.:.|..:.|:     :..::..||:..:.:|..    .||.|   .|.:..|::.
Zfish   743 KENCLFDLDFVLFTSTSVFLCIFIVVVLMYNFVGQYLKPFYHIANGWFRE---ALRMKEKQQY-- 802

  Fly   821 DKRFDAFLAFTHKDEA-LLEEFVDRLE-RGRPRFQLCFYLRDWLAGESIPDCIGQSIKDSRRIIV 883
              |:|||::::.|||. ::||.:..|| ||.|..:||.:.||:..|..|.:.|..||..|||.:.
Zfish   803 --RYDAFVSYSGKDEHWVIEELLPNLEQRGPPFLRLCLHSRDFQLGHDIVENITDSIYASRRTLC 865

  Fly   884 LMTENFMNSTWGRLEFRLALHATSRDRCKRLIVVLYPNVKN-FDSLDSELRTYMAFNTYLE---- 943
            |::.|::||.|..||.:||.:....:....||:|....:.: ..|....|...:...|||:
Zfish   866 LVSRNYLNSNWCSLEMQLATYRLQVEHRDILILVFLETIPSCLLSSHHRLARLVKTRTYLDCPQE 930

  Fly   944 -RSHPNFWNKL 953
             ..|..||::|
Zfish   931 PEMHDAFWDRL 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	7/22 (32%)
		leucine-rich repeat	346..367	CDD:275378	3/20 (15%)
		leucine-rich repeat	563..583	CDD:275378	8/25 (32%)
		leucine-rich repeat	585..610	CDD:275378	6/24 (25%)
		leucine-rich repeat	611..622	CDD:275378	0/10 (0%)
		TIR	823..960	CDD:214587	47/139 (34%)
LOC103911657	XP_009303036.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920