DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MstProx and tlr7

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	XP_021334735.1	Gene:	tlr7 / 100534776	ZFINID:	ZDB-GENE-040219-11	Length:	1036	Species:	Danio rerio

Alignment Length:	1046	Identity:	213/1046 - (20%)
Similarity:	378/1046 - (36%)	Gaps:	331/1046 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 PKSLK--IIIQSN----------------------------LYLNEIIEYINKTTDNVNEII--- 156
            |||||  :.:.||                            |.:|.|...:|.:.||::.|.
Zfish    23 PKSLKCDVSLASNGTEVSVDCTERSLTEVPLGIPTNTTNLTLTINHIPHVMNNSFDNLHNITEID 87

  Fly   157 ---------INAYKTVENQQIALDNLIFNGKSHLRSLTFIGFQI--------------------- 191
                     :.....|.:|.:::||..|....:|:||...|.|:
Zfish    88 LRCNCVPVKVGPKDRVCSQSVSIDNGTFWKLKNLKSLYLDGNQLSSIPKGLPANIVLLSLEINSI 152

  Fly   192 -----ENLSTKPFAQFINLKRMVL-TNCTVRNL----------TFLRTLQKSLEHLELDIDNEVD 240
                 |||:     :..|::.:.| .||..||.          .|:  |...:..|.|..:|
Zfish   153 YSILQENLT-----ELTNIRTLYLGQNCYFRNPCNQSYYIEKDAFM--LLDKMTLLSLKSNN--- 207

  Fly   241 LKYFTNF--SSLKFMKVRNYIPNKNFTALICTHKNCNF----IRGINGLECPKLCQCLYIIDDLE 299
            |.|..|.  ||||.:    |:.|.|... |..:..||.    :..::| .||:.....:..
Zfish   208 LSYIPNQLPSSLKEL----YLYNNNIEK-ITENDFCNLTELEVLDLSG-NCPRCYNAPFPC---- 262

  Fly   300 LNIDCSNLGLLQIPPLPIPSYGGVK-LNFSNNSLSQLPTMTLPGYKLVKRLDVSRN----RLTNL 359
              |.|.|...|||.|....:...:| |...:|||:.:|.........:..||:|.|    .:|..
Zfish   263 --IPCPNNAPLQIHPNSFKTLRNLKTLRLHSNSLTNIPPEWFQSLADLTLLDLSSNFLAKEITCT 325

  Fly   360 SINHLPAKLDYLDVSFN------------------------------------------------ 376
            |...|..||:.||:|||
Zfish   326 SFPSLLPKLEELDLSFNYELQVYPASLSLSESFSQLKSLRVLRIRGYVFQELKLQDIQPLTNLTY 390

  Fly   377 -EIINMGNDVIKYLRTVPIFKQTGNQWTIHCDDKPL-------LNFFRHLKLI--------IRMK 425
             |.:::|.:.|| :..:.|.|...|...|:..|..:       .:|..|.:..        .:..
Zfish   391 LEFLDLGTNFIK-IAQLSILKNLKNFKIINLSDNKISVPSEGEFSFSNHREAYYGSPMSQGAQYH 454

  Fly   426 SAEMKPMFLHSLTELPKGFLKFLGKHFIW---------------LGVRKQEYYLINEEQL----L 471
            :.|:|.|......|..:. .|:..|. :|               |.:.:...:.::.:.|    |
Zfish   455 NGEVKDMHYFLYDEFARS-CKYKDKE-LWIPSPFNNDCSSFGKTLDISRNNIFFLHSKFLNLGEL 517

  Fly   472 QSMHRKLNNLNTIMSIYKYMEWLH-RKLIFVNREYDLFYIRQMAAPCPHKCECCYSRDSLILKID 535
            :.::...|.::..::..::::..: :.|.|.:...||.|            ...:...|.::.:|
Zfish   518 RCLNLSGNAMSQSLNGSEFVQLTNLQYLDFTDNRLDLMY------------PSAFQELSNLVVLD 570

  Fly   536 CRNKFVYNFPDIVARNSR----------LMGKQNMSSPMELHLSKNNISNIT-IAMLPKELRFLD 589
                        ::|||.          |...:|:|...:|.::.|.||..| ..|...:|..|:
Zfish   571 ------------ISRNSHYFVAEGLTHMLNFTENLSKLRKLIMNDNQISTSTNTEMKSYKLEHLE 623

  Fly   590 LRFNNLVTL----DDKVLSYLKK-NSIKT-KLSGNPWN-------------------CDCKSRSV 629
            .:.|.|..|    |.:.::|.|. .|:|| .:|.|..|                   .|.|.:
Zfish   624 FKGNRLDMLWRDGDTRYVNYFKNLMSLKTLDISRNNLNFIPLVVFQGLPNTLTKLYITDNKLK-- 686

  Fly   630 LSILRDHEPLEYDVTLKRCNISP---TDCPDVCVCCLDNLT----------------WPSFIVDC 675
               |...|.|.|..:|...:::.   |:.|.    ||.|.|                .|:|:.|
Zfish   687 ---LFKWEGLVYLKSLLLLDLTGNLLTEVPS----CLSNYTKSIQTLVLSKNKIVKLSPNFLKD- 743

  Fly   676 RGEGLLQMPSLSSRVTYVDLRNNNLTALSQKN-RSSIENRSLKLHLLDNPWSCSCNDIEKINFMK 739
                     :.|.::  :||..|::..:.:.: ..::.:....|:|.:|.:.||||....:.::.
Zfish   744 ---------AFSLKI--LDLSYNSIQFIDESSFPENVIDHLQTLYLNNNMFVCSCNATWLVRWIN 797

  Fly   740 SVSSSIVDF-TEIKCSN-----GEKLVSIN----QH-----IVCPSDLFYYLALAISLVATIIAL 789
            ..|.:|... :::.|::     |:.::.:|    ||     |:|    .:...|.::::...|:.
Zfish   798 RTSVNIPRLASDVTCASPSAQKGQSVIFLNLQACQHNSLSIILC----IFQTTLILTILTLTISS 858

  Fly   790 NFLIWFRQPVLVWFYEHGVCLSLSAKRELDKDKR-FDAFLAFTHKDEALLEEFVDRL-----ERG 848
            :..:|.     ||:..|.....|...|.|..:.. :|||:.:...|.|:.|..:..|     ::|
Zfish   859 HLFLWD-----VWYIYHFCLAKLKGYRRLSSNSAVYDAFVIYDTTDPAVQEWVMQELRVHLEDKG 918

  Fly   849 RPRFQLCFYLRDWLAGESIPDCIGQSIKDSRRIIVLMTENFMNSTWGRLEFRLALHATSRDRCKR 913
            .||..||...|||:.|..:.:.:.|||:.|:|.:.::||.::.|...|..|.|| |....|....
Zfish   919 DPRMNLCLEERDWVPGCPLIENLSQSIQLSQRTVFILTERYIRSGSFRTAFYLA-HQRLMDERND 982

  Fly   914 LIVVLY 919
            :||:::
Zfish   983 VIVLIF 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	5/19 (26%)
		leucine-rich repeat	346..367	CDD:275378	7/24 (29%)
		leucine-rich repeat	563..583	CDD:275378	6/20 (30%)
		leucine-rich repeat	585..610	CDD:275378	8/29 (28%)
		leucine-rich repeat	611..622	CDD:275378	5/30 (17%)
		TIR	823..960	CDD:214587	32/103 (31%)
tlr7	XP_021334735.1	LRR_8	67..131	CDD:316378	15/63 (24%)
		leucine-rich repeat	83..120	CDD:275380	6/36 (17%)
		PLN00113	107..>574	CDD:331614	94/515 (18%)
		leucine-rich repeat	121..165	CDD:275380	8/48 (17%)
		leucine-rich repeat	142..157	CDD:275380	0/14 (0%)
		leucine-rich repeat	166..197	CDD:275380	7/32 (22%)
		leucine-rich repeat	199..218	CDD:275380	6/21 (29%)
		leucine-rich repeat	219..242	CDD:275380	8/27 (30%)
		leucine-rich repeat	243..283	CDD:275380	10/46 (22%)
		leucine-rich repeat	284..307	CDD:275380	6/22 (27%)
		leucine-rich repeat	308..333	CDD:275380	7/24 (29%)
		leucine-rich repeat	334..363	CDD:275380	6/28 (21%)
		leucine-rich repeat	364..390	CDD:275380	0/25 (0%)
		leucine-rich repeat	391..414	CDD:275380	6/23 (26%)
		leucine-rich repeat	415..434	CDD:275380	2/18 (11%)
		leucine-rich repeat	495..516	CDD:275380	2/20 (10%)
		leucine-rich repeat	517..541	CDD:275380	2/23 (9%)
		leucine-rich repeat	542..565	CDD:275380	5/34 (15%)
		leucine-rich repeat	566..595	CDD:275380	6/40 (15%)
		leucine-rich repeat	596..616	CDD:275380	6/19 (32%)
		leucine-rich repeat	619..649	CDD:275380	8/29 (28%)
		LRR_8	<644..685	CDD:316378	8/40 (20%)
		leucine-rich repeat	650..673	CDD:275380	5/22 (23%)
		leucine-rich repeat	675..722	CDD:275380	13/55 (24%)
		LRR_8	722..781	CDD:316378	9/70 (13%)
		leucine-rich repeat	723..746	CDD:275380	3/32 (9%)
		leucine-rich repeat	747..765	CDD:275380	3/19 (16%)
		PCC	751..>828	CDD:188093	14/76 (18%)
		TIR	889..>993	CDD:214587	32/101 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010