DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MstProx and tlr21

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	XP_002936443.3	Gene:	tlr21 / 100497009	XenbaseID:	XB-GENE-5956980	Length:	937	Species:	Xenopus tropicalis

Alignment Length:	1016	Identity:	213/1016 - (20%)
Similarity:	373/1016 - (36%)	Gaps:	303/1016 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 INSFKVIERDVHYINGPKSLKIIIQSNLYLNEIIEYINKTTDNVNEI---------IINAYKTVE 164
            |||:..|.|.   :...||....:.|:::      |:|.:.:|:..:         .:...:...
Frog    33 INSYNCIARG---LTDVKSAVGDLPSDVW------YLNISYNNIQTLHQGSFGHMPFLRTLRLNH 88

  Fly   165 NQQIALDNLIFNGKSHLRSLTFIGFQIENLSTKPFAQFINLKRMVLTNCTV--------RNLTFL 221
            ||...||...|...:.|..|.....:|.|||.:.|....|:..:.|.:..:        .:||.|
Frog    89 NQLQRLDPGAFENLTMLEKLHLSSNKISNLSKEVFCGLQNVSWLFLDDNLLSSIHPEAFSHLTNL 153

  Fly   222 RTLQKSLEHLELDIDNEVDLKYFTNFSSLKFMKVRNYIP-NKNFTALICTHKNCNFIRGINGL-E 284
            :.|..|:.:|.             ||..:    |::..| .|..|.::|:    |.|..:|.. .
Frog   154 QNLNLSMNNLH-------------NFEKV----VQSIHPLQKLNTLMLCS----NQISSLNHTHR 197

  Fly   285 CPKLCQCLYIIDDLELNIDCSNLGLLQIPPLPIPSYGGVKLNFSNNSLSQLPTMTLPGYKLVKRL 349
            .|...:.|::..:....:||.....|.|        ..:.|:::|.:.|.|.||.|
Frog   198 LPSTLRWLFLCKNQLATLDCQQDFFLNI--------SWLDLSYNNIATSSLQTMDL--------- 245

  Fly   350 DVSRNRLTNLSINHLPAKLDYLDVSFNEIINMGN-DVIKYLR--TVPIFKQTGNQWTIHCDDKPL 411
                            .|:.||:|:||     || |::.:::  ||||.:...:...::.|.| |
Frog   246 ----------------RKVIYLNVAFN-----GNFDILIFIKNPTVPINRIDYSGLNLNNDSK-L 288

  Fly   412 LNFFRHLK----LIIRMKSAEMKPMFLHSLTELP--------------KGFLKFLGK-------- 450
            ....|:||    ..:.:...::|.:...:||:.|              .|.|:|:.|
Frog   289 KTMCRYLKGFNINTLYLSGNKIKTLNRGTLTDCPLNKTLDLSRNRLKGLGCLEFMSKTNVENLIV 353

  Fly   451 ---------------HF------------IWLGVRKQEYYLINEEQLLQSMHRKLNNL------- 481
                           ||            ||:......::..|    ||:::..:||:
Frog   354 EHNLLKELINCSKKSHFPRLRHISFRYNRIWIVKGNAFHFAPN----LQTLYLNINNIVFLERYS 414

  Fly   482 --------------NTIMSIYKYMEWLHRKLIFVN-REYDLFYIRQMAAPCPHKCECCYSRDSLI 531
                          |.|..:|:..        |.| .|..:..:|.             :|.|:|
Frog   415 FSGLGKLRELRLDNNLITDLYENS--------FANLTELRILNLRN-------------NRVSVI 458

  Fly   532 LKIDCRNKFVYNFPDIVA-----------RNSRLMGKQNMSSPMELHLSKNNI--------SNIT 577
            .     :|..||...:..           :|....|.:::|   :|:|..|.|        |::.
Frog   459 F-----SKVFYNLGKLTTLDLGGNKITQLKNQSFYGLRSLS---KLYLDGNQIKEISRYVFSHVE 515

  Fly   578 IAMLPKELRFLDLRFNNLVTLDDKVLSYLKKNSIKTKLSGNPWNCDCKSRSVLSILRDHEPLEYD 642
            ..:|..:|:...||:|.........|:..|...:|.: :..|:......:.....|:..:.|.
Frog   516 STLLVLDLKSNHLRYNTTRETYSPFLTLSKLYDLKLQ-AQQPYGLTAIPQGFFKGLKSLKALY-- 577

  Fly   643 VTLKRCNISPTDCPDVCVCCLDNLTWPSFIVDCRGEGLLQMP-----SLSSRVTYVDLRN----- 697
            :...|.:...:|..:.    |..||:.|...||  .|:.::|     :|.: :..:||.|
Frog   578 LAQNRISSLSSDAFNE----LGQLTYLSLAEDC--NGIQRLPPGIFKNLKN-LQILDLENICLQY 635

  Fly   698 ------NNLT----------ALSQKNRSSIENRS-LK-LHLLDNPWSCSCNDIEKINFMKSVSSS 744
                  ::||          ||:..|....||.: || |.|...|.||:||:.|...:.|.....
Frog   636 MRMEVFSSLTNLKRLLLTKNALTHINIKVFENMTQLKYLDLRKCPLSCTCNNAELQMWFKKGPVQ 700

  Fly   745 IVDFTEIKCSNGEKL-----------VSINQHIVCPSD----LFYYLALAISLVATIIALNFLIW 794
            ||....:.|...|..           :.|...:.|.|.    ||..:.:..|....:|..|:.::
Frog   701 IVLPYNLTCPANENSYFHDFDTHVCDMEIKIKLFCSSFTSILLFIIIPIVYSKFYWMIKYNYFLF 765

  Fly   795 FRQPVLVWFYEHGVCLSLSAKRELDKDKRFDAFLAF-THKDEALLEEFVDRLERGRPRFQLCFYL 858
                 :.|.:|.     ..:::||.|   :|||::: ||.:|.:.:..:..||....|  ||.:.
Frog   766 -----VAWLHER-----WKSEKELYK---YDAFVSYNTHDEEWVYKIMLPVLETSALR--LCLHH 815

  Fly   859 RDWLAGESIPDCIGQSIKDSRRIIVLMTENFMNSTWGRLEFRLALHATSRDRCKRLIVVLYPNVK 923
            ||:..|..|.|.|..||.:||:.|.:::.:::.|.|..||.:||.:....:....|:::|..|:.
Frog   816 RDFQLGRDIIDNIVDSIHNSRKTICVVSRSYLQSEWCSLEMQLASYKLFDEMRDVLVLILLDNIP 880

  Fly   924 NFDSLDSELRTY------MAFNTYL-----ERSHPNFWNKL 953
                 |.||.||      |...||:     ..:...||.|:
Frog   881 -----DRELSTYHRMRKLMLKKTYITWPTEPEAQQLFWAKV 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	7/19 (37%)
		leucine-rich repeat	346..367	CDD:275378	0/20 (0%)
		leucine-rich repeat	563..583	CDD:275378	6/27 (22%)
		leucine-rich repeat	585..610	CDD:275378	6/24 (25%)
		leucine-rich repeat	611..622	CDD:275378	2/10 (20%)
		TIR	823..960	CDD:214587	42/143 (29%)
tlr21	XP_002936443.3	PLN00113	<46..>528	CDD:215061	108/580 (19%)
		leucine-rich repeat	59..80	CDD:275380	3/20 (15%)
		leucine-rich repeat	81..104	CDD:275380	5/22 (23%)
		leucine-rich repeat	105..128	CDD:275380	7/22 (32%)
		leucine-rich repeat	129..152	CDD:275380	2/22 (9%)
		leucine-rich repeat	153..224	CDD:275380	18/91 (20%)
		leucine-rich repeat	225..299	CDD:275380	27/112 (24%)
		leucine-rich repeat	300..323	CDD:275380	3/22 (14%)
		leucine-rich repeat	348..363	CDD:275378	0/14 (0%)
		leucine-rich repeat	373..396	CDD:275380	2/22 (9%)
		inl_like_NEAT_1	<397..>652	CDD:411101	52/293 (18%)
		leucine-rich repeat	397..420	CDD:275380	4/22 (18%)
		leucine-rich repeat	421..444	CDD:275380	5/30 (17%)
		leucine-rich repeat	445..468	CDD:275380	7/40 (18%)
		leucine-rich repeat	469..492	CDD:275380	2/22 (9%)
		leucine-rich repeat	493..516	CDD:275380	6/25 (24%)
		leucine-rich repeat	518..572	CDD:275380	10/54 (19%)
		leucine-rich repeat	573..596	CDD:275380	4/28 (14%)
		leucine-rich repeat	597..622	CDD:275380	8/26 (31%)
		leucine-rich repeat	623..646	CDD:275380	4/22 (18%)
		leucine-rich repeat	647..668	CDD:275380	4/20 (20%)
		TIR	781..923	CDD:214587	43/146 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010