DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MstProx and XB5889249

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	XP_017950848.2	Gene:	XB5889249 / 100495326	XenbaseID:	XB-GENE-5889250	Length:	796	Species:	Xenopus tropicalis

Alignment Length:	919	Identity:	209/919 - (22%)
Similarity:	347/919 - (37%)	Gaps:	254/919 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 NLY-LNEIIEYINKTTDNVNEIIINAYKTVENQQIALDNLIFNGKSHLRSLTFIGFQIENLSTKP 198
            ||| |..||.||....::...:||         |..|.....:..|....|.|....|.:|.|..
Frog     9 NLYFLFAIIIYILTQFESNKALII---------QRKLHKCFSSCPSVCTLLDFTKENITHLKTSD 64

  Fly   199 FAQFINLKRMVLT-------NCTVRNLTFLRTLQKSLEHLELDIDN------------------E 238
            |..|:.|:.:.|:       :|:|..      ...|||:  |||.|                  .
Frog    65 FNCFLQLRLLNLSHNLIGELDCSVFK------FNPSLEY--LDISNNRLHTIKCHSLQYIKNIKR 121

  Fly   239 VDLKYFTNFSSLKFMKVRNYIPNKNFTALICTHKNCNFIRGINGLECPKLCQCLYIIDDLELNID 303
            :||.| .||.::.|.        ..||||       :.::.: ||...|: |....|:...:::|
Frog   122 MDLSY-NNFKTMDFC--------SEFTAL-------SQLKHL-GLSSKKI-QKDSFINIASMDLD 168

  Fly   304 CSNLGLLQIPPLPIPSYGGVKLNFSNNSLSQLPTMTLPGYKLVKRLDVSRNRLTNLSINHLPAKL 368
            ...||:..            ::.:.|.||..|.|         .:|.:  |...|||:.......
Frog   169 FVFLGIEN------------EIEYENGSLQFLNT---------NKLHI--NLQPNLSLASSYLLS 210

  Fly   369 DYLDVSFNEIINMGNDVIKYLRTVPIFKQTGNQWTIHCDDKPLLNFFRHLKLIIRMKSAEMKPMF 433
            |.||.|..                  .:.:|.|..:|||      :|......|. |::::..:.
Frog   211 DALDTSMT------------------LEVSGAQCDVHCD------YFTKSFFTIN-KNSKVVNLI 250

  Fly   434 LHSLTELPKGFLKFLGKHFIWLGVRKQEYYLINEEQLLQSMHRKLNNLNTIMSIYKY--MEWLHR 496
            :.:.|......||.:..  ||             :..::.:|.|:..|   :..:||  |::.|.
Frog   251 ISNSTMPGNEMLKIIPP--IW-------------DSSVEHLHIKMFRL---IKEFKYVKMDFTHH 297

  Fly   497 KLIFVNREY---DLFYIRQMAAPCPHKCECCYSRDSLILKIDCRNKFVYNF-----PDIV----A 549
            .:.....||   |:|:. |...|.....|      .|:..:...|..:.:|     |.||    .
Frog   298 SIKSFTLEYFTNDVFFF-QGTHPFNIFAE------MLVENVTFSNAGMIHFFCPPVPSIVRFLNL 355

  Fly   550 RNSRLMGK--QNMSSPMELHL--SKNN-------ISNITIAMLPKELRFLDLRFNNLVTLDDKVL 603
            .::|:..:  .|.||..||.|  .:||       ||::|:.|  |.|:.|||..|.|...::|..
Frog   356 PSNRITDEIFLNCSSLNELELLNLQNNKLEQMSKISSMTLKM--KNLKHLDLSKNGLHIDNEKQC 418

  Fly   604 SYLKK----NSIKTKLSGNPWNC--------DCKSRSVLSILRDHEPLEYD--VTLKRCNISP-- 652
            :::..    |..::.|:.:.:.|        |.....:.||     |:|..  |:||..:::.
Frog   419 NWMDSLVFLNLSESGLTNSVFGCLPINLQILDLSKNQISSI-----PIEVKNFVSLKELHLASNR 478

  Fly   653 -TDCPDVCVCCLDNLTWPSFIVDCRGEGLLQMPSLSSRVTYVDLRNNNLTALSQKNRSSIENRSL 716
             ||.|| |....:||            |:|::             :.|...|..|  ..::|...
Frog   479 LTDIPD-CHNIGNNL------------GVLKV-------------DENFINLPPK--EFLQNCEY 515

  Fly   717 KLHLL--DNPWSCSCNDIEKINFMKSVSSSIVDFTE-IKCSNGEKLVSI------NQHIVCPSDL 772
            ..:|.  .||:.|:|:..|.:.........:|.:.| .||::.|.:..|      ...|.|.:.|
Frog   516 VQYLSAGQNPFQCNCDLREFVKMGVMFPKRLVGWPESYKCADPENVKGIFLQDFHLSEISCNTSL 580

  Fly   773 FYYLALAISLVATIIALNFLIWFRQPVLV-----WFYEHGVCLSLSAKRELDKDKRFDAFLAFTH 832
            |..:.|....|.:||.::...:|..|..:     ||.......::: ::::..||.|.||::::.
Frog   581 FLGVVLGTIFVVSIIVVSACFYFDVPWYIRMLFRWFRTKHRLRNVN-QQDIQNDKLFHAFISYSQ 644

  Fly   833 KDEALLEE-FVDRLERGRPRFQLCFYLRDWLAG----ESIPDCIGQSIKDSRRIIVLMTENFMNS 892
            :|...::. .:..|||.....::|.:.|.::.|    |:|.|||.:|.|.    |.:::.||:.|
Frog   645 EDSDWVKNMLLPNLERKDGSIKICHHERHFIPGKAIIENIIDCIEKSFKS----IFVLSPNFIQS 705

  Fly   893 TWGRLEFRLALHATSRDRCKRLIVVL--------YPNVKNFDSLDSELRTYMAFNTYLE-----R 944
            .|...|...|.|.........||::|        .||..|      :||:.|...||||     .
Frog   706 DWCHYELYFAQHTLFGKNSNNLILILLDPIPQYSIPNKYN------KLRSIMKHRTYLEWPKEKG 764

  Fly   945 SHPNFWNKL 953
            .|..||..|
Frog   765 KHALFWANL 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	5/19 (26%)
		leucine-rich repeat	346..367	CDD:275378	5/20 (25%)
		leucine-rich repeat	563..583	CDD:275378	9/28 (32%)
		leucine-rich repeat	585..610	CDD:275378	7/28 (25%)
		leucine-rich repeat	611..622	CDD:275378	1/10 (10%)
		TIR	823..960	CDD:214587	42/149 (28%)
XB5889249	XP_017950848.2	leucine-rich repeat	48..70	CDD:275378	7/21 (33%)
		PLN00113	50..>484	CDD:215061	117/539 (22%)
		LRR_8	70..129	CDD:404697	14/67 (21%)
		leucine-rich repeat	71..94	CDD:275378	4/28 (14%)
		leucine-rich repeat	95..118	CDD:275378	6/24 (25%)
		leucine-rich repeat	119..143	CDD:275378	10/39 (26%)
		LRR	<398..>524	CDD:227223	33/158 (21%)
		leucine-rich repeat	400..423	CDD:275380	7/22 (32%)
		leucine-rich repeat	424..445	CDD:275378	3/20 (15%)
		leucine-rich repeat	446..468	CDD:275378	5/26 (19%)
		leucine-rich repeat	469..491	CDD:275378	7/22 (32%)
		leucine-rich repeat	492..515	CDD:275378	7/49 (14%)
		leucine-rich repeat	516..528	CDD:275378	3/11 (27%)
		LRRCT	524..576	CDD:214507	12/51 (24%)
		TIR	636..777	CDD:214587	42/148 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020