DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MstProx and tlr6

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	XP_017950845.1	Gene:	tlr6 / 100493946	XenbaseID:	XB-GENE-492949	Length:	842	Species:	Xenopus tropicalis

Alignment Length:	865	Identity:	191/865 - (22%)
Similarity:	323/865 - (37%)	Gaps:	259/865 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 IDNEVDLKYFTNFSSLKFMKVRNYIPNKNFTALICTHKNCNFIRGINGLECPKLCQCLYIIDDLE 299
            :..|:...:..|:|: ||:    :...||.::| .|..:.:|    |.:...:..:..||.|...
Frog    18 VRQEIFESHIANYSN-KFL----FAVPKNLSSL-TTVLDISF----NSIATMETSEFNYIFDLQV 72

  Fly   300 LNIDCSNLGLLQIPPLPIPSYGGVKLNFSNNSLSQLPTMTLPGYKLVKRLDVSRNRLTNLSINHL 364
            ||                .||.  |:.:.|:|:.:..|.       ::.||.|.|.|.|:| ...
Frog    73 LN----------------ASYN--KMKYLNSSIFKFNTQ-------LQYLDFSHNVLRNIS-GTF 111

  Fly   365 PAKLDYLDVSFNEIINM------GNDV-IKYLRTVPIFKQTGNQWTIHCDDKPLLNFFRHLKLII 422
            |:.:.:||:|||....:      ||.| ::||       ..|....:..|.:.:::.  |||.:.
Frog   112 PSHIQHLDISFNNFQTLSVCSGFGNMVLLEYL-------GLGADQILKSDFEGIVHL--HLKEVF 167

  Fly   423 RMKSAEMKPMFLHSLTELPKGFLKFLGKHFIWL--GVRKQE------YYLINEEQLLQSMHRKLN 479
                     :.|:||.:...|.|..|....:.|  ||...|      :..:|...:|:..|  |.
Frog   168 ---------IELNSLNDYENGSLLLLNTKKLTLDFGVLSNEDRYNVLFDAVNTTSVLELSH--LQ 221

  Fly   480 NLNTIMSIYKY-------------------MEWLHRKLIFVNRE------------YDLFYIRQM 513
            ..|..:...||                   :||   |:|.:..:            || |.::.:
Frog   222 RWNIHIDPKKYIFNIVQNSKVTDLTMRHVNVEW---KMIVLALQYIWHSSVETLTFYD-FSLKGL 282

  Fly   514 AAPCPHKCECCYSRDSL-ILKIDCRNKFVYNFPDIVARNSRLMGKQNMSSPMELHLSKNNISNIT 577
            .|    |....||..|: .:.:...|..|:.|              :.||...: .|..||.|:|
Frog   283 IA----KTSFDYSNTSVKAVNVQGVNVGVFQF--------------DQSSVYRV-FSNMNIENLT 328

  Fly   578 I-------AMLP-KELRFLDLRFNNLVTLDD-----------KVLSYLKKNSIKT--KLSGNPWN 621
            :       .:.| ....|..:.|::....||           |.|. |:||.::.  |||....|
Frog   329 LNFASLLFMVCPLNSSTFQSIDFSHNALTDDLFKDCFTLINLKRLK-LRKNKLEKIYKLSAMTEN 392

  Fly   622 CDCKSRSVLSILRDHEPLEYDVTLKRCNISPTDCPDVCVCCLDNLTWPSFIVD------------ 674
            ..    |:..:...|..|.||         ..||           .|...||:
Frog   393 MP----SLEYLDASHNLLAYD---------EEDC-----------HWSQNIVELNLASNFLTASI 433

  Fly   675 --C----------RGEGLLQMPSLSSRVTYVD------LRNN---------NLTALS----QKNR 708
              |          ....:..:|   |.||::|      |..|         |:::||    :.|:
Frog   434 FKCLPISIKILILESNDITHVP---SGVTHLDDLVELNLSFNRLGDLPDCSNISSLSLLGVEGNQ 495

  Fly   709 ------SSIENRSLKLHLL--DNPWSCSCNDIEKINFMKSVSSSIVDFTE-IKCSNGEKL----- 759
                  .|||:.|...|:.  .||:.|:|.....||..|....:::.:.| ..|...:.|
Frog   496 ILYPSIESIESCSRVKHISAGQNPFQCNCELRRFINQEKEAPGTLIGWPEAYVCKYPDHLRGTML 560

  Fly   760 -------VSINQHIVCPSDLFYYLALAISLVATIIALNFLI---WFRQPVLVWFYEHGVCLSLSA 814
                   ::.|..|:.|   ...|.:.|| :|.||.|...:   ||.:  ::|.|......:.::
Frog   561 KDFYISEITCNVFILIP---VIILPIIIS-IALIIGLCKYLDGPWFLK--MIWQYTRTKQRTRTS 619

  Fly   815 K---RELDKDKRFDAFLAFTHKDEALLEE-FVDRLERGRPRFQLCFYLRDWLAGESIPDCIGQSI 875
            |   :.|.:|..|:||::::..|.:.::. |:..:||.....::|.:.|:::.|:||.:.|...|
Frog   620 KQGYQSLQRDFDFNAFISYSEHDASWVKNIFLPSIERSNDCIRICQHERNFIPGKSIIENIINCI 684

  Fly   876 KDSRRIIVLMTENFMNSTWGRLEFRLALHATSRDRCKRLIVVLYPNVKNF--DSLDSELRTYMAF 938
            :.|.:.|.:::.||:.|.|...|...|.|....:....||::|...:..:  .|...:|:|.||.
Frog   685 EKSYKSIFILSPNFVQSEWCHYELYFAHHKLYTENNDNLILILLEPIPQYLIPSKYYKLKTLMAQ 749

  Fly   939 NTYLE-----RSHPNFWNKL 953
            .||||     ..|..||..|
Frog   750 RTYLEWPSEKSKHGLFWANL 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	3/19 (16%)
		leucine-rich repeat	346..367	CDD:275378	8/20 (40%)
		leucine-rich repeat	563..583	CDD:275378	6/27 (22%)
		leucine-rich repeat	585..610	CDD:275378	8/35 (23%)
		leucine-rich repeat	611..622	CDD:275378	3/12 (25%)
		TIR	823..960	CDD:214587	39/139 (28%)
tlr6	XP_017950845.1	leucine-rich repeat	46..69	CDD:275378	5/26 (19%)
		LRR_8	70..125	CDD:404697	21/80 (26%)
		leucine-rich repeat	70..93	CDD:275378	7/40 (18%)
		leucine-rich repeat	94..114	CDD:275378	8/20 (40%)
		leucine-rich repeat	115..139	CDD:275378	7/23 (30%)
		LRR_RI	311..>478	CDD:423007	39/195 (20%)
		leucine-rich repeat	347..369	CDD:275380	3/21 (14%)
		leucine-rich repeat	370..395	CDD:275380	9/29 (31%)
		leucine-rich repeat	396..418	CDD:275380	7/41 (17%)
		leucine-rich repeat	419..440	CDD:275380	3/20 (15%)
		leucine-rich repeat	441..463	CDD:275380	4/24 (17%)
		leucine-rich repeat	464..485	CDD:275380	3/20 (15%)
		leucine-rich repeat	486..509	CDD:275380	6/22 (27%)
		LRRCT	518..570	CDD:214507	10/51 (20%)
		TIR	632..775	CDD:214587	39/138 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020