DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MstProx and tlr13

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	XP_002935047.2	Gene:	tlr13 / 100485164	XenbaseID:	XB-GENE-5873547	Length:	948	Species:	Xenopus tropicalis

Alignment Length:	1025	Identity:	212/1025 - (20%)
Similarity:	382/1025 - (37%)	Gaps:	296/1025 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 DYLRQLGVETVTRFE------NQINSFKVIERDVHYING------PKSLKIIIQSNLYLNEIIEY 144
            :|...:|...||..:      .|.....:.|.::..|:|      ||..:::::.| .:|.:..:
Frog    39 EYANCVGQSVVTLADAIQDLPYQTRVLNISENEISKIDGYTFSHLPKLQELVLRKN-KVNGVDTW 102

  Fly   145 INKTTDNVNEIII--NAYKTVENQQIALDNLIFNGKSHLRSLTFIGFQIENLSTKPFAQFINLKR 207
               ...|:|:::|  .:|..::    :||.:......||:.......:|..:..........|:.
Frog   103 ---AFHNLNDLLILDLSYNLIQ----SLDTVDLTDLKHLQIFDLSHNRIHTIQMGTLGPLGALQE 160

  Fly   208 MVLTNCTVRNLTFLRTLQKSL----EHLELDIDNE--VDLK---YFTNFSSLKFMKVRNYIPNKN 263
            :.|   :..|::..|::..::    :.|.|.:.:.  .|||   ..|..|||:.:.:||
Frog   161 LDL---SFNNVSDFRSVANAVSQLPDFLRLSLSSNFITDLKSEQSVTVLSSLQSLNLRN------ 216

  Fly   264 FTALICTHKNCNFIRGINGLECPKLCQCLYIIDDLELNIDCSNLGLL------QIPPLPIPSYGG 322
                     |...:........|.|         :|||:..:||..:      .:|.|
Frog   217 ---------NSISVLDFTFYSMPSL---------IELNVTRNNLSAVNKSSFSNLPML------- 256

  Fly   323 VKLNFSNNSL--SQLPTMTLPG--------------YKLV------------KRLDVSRNRL--T 357
            .|:.|..|||  |||..:.||.              ::||            :.||:..:::  |
Frog   257 AKVTFDENSLNISQLLGLVLPNLTEFHWSSMRPALQHELVSACQVFQTFPKLQLLDIKHSKIAVT 321

  Fly   358 NLSI--------------NHLP--AKLDYLDVSFNEIINMGNDVIKYLRTVPIFKQTGNQWTIHC 406
            ||||              :.||  .:.|..|..:.|::        ||....:.:...:.|
Frog   322 NLSIIGRCTNLTSLILSTSPLPRLQEKDLQDFKYLEVL--------YLDKCKLRRIANSSW---- 374

  Fly   407 DDKPLLNFFRHLKLIIRMKSAEMKPMFLHSLT-----ELPKGFLKFLGKHFIWLGVRKQEYYLIN 466
              :.|.|.  |..::.|.:.::::......||     :|.|.:|..|.:. .:.|:|:..|..:.
Frog   375 --RGLNNL--HTLILERNQLSDLEDKLFSPLTSLQYLDLSKNYLTHLNEK-AFSGLRRLNYLSLK 434

  Fly   467 EEQL---LQSMHRKLNNLNTIMSIYKYMEWLHRKLIFVNREYDLFYIRQMAAPCPHKCECCYSRD 528
            ..::   .::..|..:||..:.        |....|.:.:.....|:|::              :
Frog   435 GCKITAATRNNFRYFSNLRVLD--------LQDNSISLIKSNAHIYLRKL--------------E 477

  Fly   529 SLILKIDCRNKFVYNFPDIVARNSRLMGKQNMSSPMELHLSKNNISNIT--IAMLPKELRFLDLR 591
            :|:|.   .||.:     .:.:|    |.:.:.|..||.|:.|||..||  .....|.||.|||.
Frog   478 TLLLS---GNKIL-----TIQKN----GLKGLVSLKELSLANNNIYKITDNTFKFVKSLRSLDLS 530

  Fly   592 ---------------FNNLVTLDDKVLSYLKKNSI--------------KTKLSGNPWNCDCKSR 627
                           |.||..|:....||..:.:|              ..:|.|||
Frog   531 RNQLWPLHKFQSPTPFLNLTQLEYLDASYQAEGNIYIPASLFQGLQSLKVLRLQGNP-------- 587

  Fly   628 SVLSILRDHEPLEYDVTLKRCNISPT----DCPDVC--------VCCLDNLTWPSFIVDCRGEGL 680
               |....:...|:.:.|...:||.|    ..|.:.        :..|.|||     :|..|...
Frog   588 ---SAFFRNVSFEFLLNLTELDISATVYTMTDPPISFEKELFKKLGQLRNLT-----LDNNGIQF 644

  Fly   681 L------QMPSLSSRVTYVDLRNNNLTALSQKNRSSIENRSLKLHLLD---NPWSCSCNDIEKIN 736
            |      .:|.|.    ::.||.|.||.:|:....::.|    |:..|   |..||||::....|
Frog   645 LPEDVFTNVPMLE----HISLRYNRLTNISEDILKNVPN----LNYFDMYMNTLSCSCDNYWFQN 701

  Fly   737 FMKSVSSSIVDFTE-IKC---SNGEKLVSINQHIVCPSDLFYYLALAISLVATIIALNFL----- 792
            :.|..:...:.|.: .||   ...|.|........|.:..:|:...:..:..:::.:|.|
Frog   702 WSKCNTEVQIPFIQSYKCFGLEANEMLFENQDFSFCTNTGYYFFLGSFIITFSLLTVNLLVVKLK 766

  Fly   793 -----------IWFRQPVLVWFYEHGVCLSLSAKRELDKDKRFDAFLAFTHKDEA-LLEEFVDRL 845
                       :|||     |..|           ..||..::||::::...||. ::|:.:..|
Frog   767 WTVRYMYCMLEVWFR-----WKLE-----------TTDKVHKYDAYISYCEDDEIWVVEKLLHML 815

  Fly   846 -ERGRPRFQLCFYLRDWLAGESIPDCIGQSIKDSRRIIVLMTENFMNSTWGRLEFRLALHATSRD 909
             |:|:.:|:|||..||::.|....|.|..:|.:||:.:.:::..::.|.|.|.|.:||.......
Frog   816 EEQGQRKFKLCFKPRDFVPGIYHLDNIQDAISNSRKTLCVVSRKYLESEWCREEMQLACSWAFSY 880

  Fly   910 RCKRLIVVLYPNVKNFD-SLDSELRTYMAFNTYLE-----RSHPNFWNKL 953
            :...|::|....:..:. |...:||..:..|||::     |....||.||
Frog   881 KEDVLLMVFLEEIPEYRLSAYHKLRKLIKQNTYIDWPEDPRGEEVFWLKL 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	9/35 (26%)
		leucine-rich repeat	346..367	CDD:275378	10/50 (20%)
		leucine-rich repeat	563..583	CDD:275378	8/21 (38%)
		leucine-rich repeat	585..610	CDD:275378	11/39 (28%)
		leucine-rich repeat	611..622	CDD:275378	5/24 (21%)
		TIR	823..960	CDD:214587	39/139 (28%)
tlr13	XP_002935047.2	LRR_RI	<29..220	CDD:238064	37/206 (18%)
		leucine-rich repeat	62..85	CDD:275380	3/22 (14%)
		LRR_8	63..144	CDD:290566	15/88 (17%)
		leucine-rich repeat	86..133	CDD:275380	8/54 (15%)
		LRR_8	132..192	CDD:290566	9/62 (15%)
		leucine-rich repeat	134..157	CDD:275380	2/22 (9%)
		leucine-rich repeat	158..208	CDD:275380	10/52 (19%)
		LRR_8	186..242	CDD:290566	16/79 (20%)
		leucine-rich repeat	209..231	CDD:275380	4/36 (11%)
		leucine-rich repeat	232..307	CDD:275380	20/90 (22%)
		LRR_RI	253..534	CDD:238064	70/338 (21%)
		leucine-rich repeat	308..331	CDD:275380	7/22 (32%)
		leucine-rich repeat	332..355	CDD:275380	4/22 (18%)
		leucine-rich repeat	356..379	CDD:275380	5/36 (14%)
		LRR_8	379..438	CDD:290566	12/61 (20%)
		leucine-rich repeat	380..403	CDD:275380	3/24 (13%)
		leucine-rich repeat	404..427	CDD:275380	5/23 (22%)
		leucine-rich repeat	428..451	CDD:275380	2/22 (9%)
		leucine-rich repeat	452..475	CDD:275380	4/30 (13%)
		LRR_8	474..534	CDD:290566	22/85 (26%)
		leucine-rich repeat	476..499	CDD:275380	6/48 (13%)
		LRR_8	499..587	CDD:290566	24/87 (28%)
		leucine-rich repeat	500..523	CDD:275380	8/22 (36%)
		leucine-rich repeat	524..577	CDD:275380	12/52 (23%)
		leucine-rich repeat	578..631	CDD:275380	11/63 (17%)
		LRR_8	631..685	CDD:290566	17/66 (26%)
		leucine-rich repeat	632..655	CDD:275380	7/27 (26%)
		leucine-rich repeat	656..676	CDD:275380	7/23 (30%)
		TIR	792..935	CDD:214587	39/139 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920