Protein Alignment SMAD4 and smad4a

DIOPT Version :10

• Sequence 1: NP_005350.1
• Gene: SMAD4 / 4089
• HGNCID: 6770
• Length: 552
• Species: Homo sapiens
• Sequence 2: XP_017213465.1
• Gene: smad4a / 559111
• ZFINID: ZDB-GENE-990603-8
• Length: 548
• Species: Danio rerio
• Alignment Length: 554
• Identity: 487/554 - (87%)
• Similarity: 512/554 - (92%)
• Gaps: 11/554 - (1%)

Human     4 MSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHP 68
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish     1 MSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHP 65

Human    69 SKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHY 133
            ||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||
Zfish    66 SKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQFAFDLKCDSVCVNPYHY 130

Human   134 ERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSL-STEGHSIQTIQHPPSNRASTETYST 197
            |||||||||||||||..:.||.:||||||  |::|.||| ||||| :||||||||...:.|.:||
Zfish   131 ERVVSPGIDLSGLTLSGSGPSGLMVKDEY--DYDGPPSLPSTEGH-MQTIQHPPSRAVTQEPFST 192

Human   198 PALLAPSE-SNATSTANFPNIPVASTSQPASILGGSH-SEGLLQIASGPQPGQQQNGF-TGQPAT 259
            ||||.|:| |::.|::.|.:|.|.||:||.|:|.||| |:.|||||||...|.||||| .||.:|
Zfish   193 PALLPPAEGSSSASSSAFSSIAVGSTTQPGSVLSGSHSSDSLLQIASGTGQGSQQNGFPPGQTST 257

Human   260 YHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHP-APEYW 323
            ||||.|::|  ||.:.:||::|||||||||||||| .||.||||||||:|||||||||| |||||
Zfish   258 YHHNPTSSW--SRNSNFTPSVPHHQNGHLQHHPPM-AHPAHYWPVHNEIAFQPPISNHPAAPEYW 319

Human   324 CSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQ 388
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   320 CSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQ 384

Human   389 LECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAAT 453
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   385 LECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAAT 449

Human   454 AQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSI 518
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   450 AQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSI 514

Human   519 KETPCWIEIHLHRALQLLDEVLHTMPIADPQPLD 552
            ||||||||||||||||||||||||||||||.|||
Zfish   515 KETPCWIEIHLHRALQLLDEVLHTMPIADPTPLD 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMAD4	NP_005350.1	Mediates interaction with ZBTB7A. /evidence=ECO:0000269|PubMed:25514493	1..322		256/322 (80%)
		MH1_SMAD_4	14..138	CDD:199816	122/123 (99%)
		Required for interaction with TSC22D1. /evidence=ECO:0000269|PubMed:15881652	44..69		24/24 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	168..194		17/26 (65%)
		Pneumo_att_G	<176..>281	CDD:114270	60/107 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	236..256		13/20 (65%)
		SAD	275..320		36/45 (80%)
		MH2_SMAD_4	320..541	CDD:199823	220/220 (100%)
smad4a	XP_017213465.1	MH1_SMAD_4	11..135	CDD:199816	122/123 (99%)
		PAT1	<164..>314	CDD:401645	99/153 (65%)
		MH2_SMAD_4	316..537	CDD:199823	220/220 (100%)