Protein Alignment SMAD4 and Smad4

DIOPT Version :10

• Sequence 1: NP_005350.1
• Gene: SMAD4 / 4089
• HGNCID: 6770
• Length: 552
• Species: Homo sapiens
• Sequence 2: NP_062148.1
• Gene: Smad4 / 50554
• RGDID: 3033
• Length: 552
• Species: Rattus norvegicus
• Alignment Length: 552
• Identity: 545/552 - (98%)
• Similarity: 546/552 - (98%)
• Gaps: 0/552 - (0%)

Human     1 MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNG 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNG 65

Human    66 AHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNP 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 AHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNP 130

Human   131 YHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGHSIQTIQHPPSNRASTETY 195
            |||||||||||||||||||||||.||:|||||||||||||||.||||||||||||||||||||||
  Rat   131 YHYERVVSPGIDLSGLTLQSNAPPSMLVKDEYVHDFEGQPSLPTEGHSIQTIQHPPSNRASTETY 195

Human   196 STPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEGLLQIASGPQPGQQQNGFTGQPATY 260
            |.||||||||||||||.|||||||||||||||||.||||||||||||||||||||||||.|||||
  Rat   196 SAPALLAPSESNATSTTNFPNIPVASTSQPASILAGSHSEGLLQIASGPQPGQQQNGFTAQPATY 260

Human   261 HHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCS 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 HHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCS 325

Human   326 IAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLE 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   326 IAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLE 390

Human   391 CKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQ 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   391 CKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQ 455

Human   456 AAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKE 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   456 AAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKE 520

Human   521 TPCWIEIHLHRALQLLDEVLHTMPIADPQPLD 552
            ||||||||||||||||||||||||||||||||
  Rat   521 TPCWIEIHLHRALQLLDEVLHTMPIADPQPLD 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMAD4	NP_005350.1	Mediates interaction with ZBTB7A. /evidence=ECO:0000269|PubMed:25514493	1..322		313/320 (98%)
		MH1_SMAD_4	14..138	CDD:199816	123/123 (100%)
		Required for interaction with TSC22D1. /evidence=ECO:0000269|PubMed:15881652	44..69		24/24 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	168..194		24/25 (96%)
		Pneumo_att_G	<176..>281	CDD:114270	100/104 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	236..256		19/19 (100%)
		SAD	275..320		44/44 (100%)
		MH2_SMAD_4	320..541	CDD:199823	220/220 (100%)
Smad4	NP_062148.1	Mediates interaction with ZBTB7A. /evidence=ECO:0000250|UniProtKB:Q13485	1..322		313/320 (98%)
		MH1_SMAD_4	14..138	CDD:199816	123/123 (100%)
		Required for interaction with TSC22D1. /evidence=ECO:0000250|UniProtKB:Q13485	44..69		24/24 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	167..193		24/25 (96%)
		SAD	275..320		44/44 (100%)
		MH2_SMAD_4	320..541	CDD:199823	220/220 (100%)