DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMAD4 and Dad

DIOPT Version :10

Sequence 1:NP_005350.1 Gene:SMAD4 / 4089 HGNCID:6770 Length:552 Species:Homo sapiens
Sequence 2:NP_001369021.1 Gene:Dad / 42059 FlyBaseID:FBgn0020493 Length:665 Species:Drosophila melanogaster


Alignment Length:569 Identity:125/569 - (21%)
Similarity:188/569 - (33%) Gaps:222/569 - (39%)


- Green bases have known domain annotations that are detailed below.


Human     9 TPTSNDACLSI--------VHSLMCHRQGGE--SETFAKRAIESLVKKLKEK---------KDEL 54
            |.:::.:.|:|        .|......|.|:  .|.|     |:|:|:||.|         |..|
  Fly   185 TESTSGSTLTIPVSTSRATAHPPQTQAQNGKRFREDF-----EALMKQLKRKQRNELLLAVKSRL 244

Human    55 D-------SLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDL-HKNELKH 111
            |       .::...||......:|:.|    ..:.|....   |||..:||:.|.:| :..|||.
  Fly   245 DPPTKTQRDVVEPTTTTAPTYLQCILI----PCKTQTVWE---PHVTASRLFFWRELWNAKELKR 302

Human   112 VKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEG 176
            :..|..|.|  |..:|.||.|:.|::                                       
  Fly   303 LPTCPAARD--CIYMCCNPLHWFRIL--------------------------------------- 326

Human   177 HSIQTIQHPPSNRASTETYSTPALL--------APSESNATSTANFPNIPVASTSQPASILGGSH 233
                   |.|...:.|..|....:|        ..|:::|.|.|      :::.|..::.:...:
  Fly   327 -------HQPETESPTPPYQRSKMLRLKDADFEEDSQNDAKSAA------LSTWSAESTSISNIY 378

Human   234 SEGLLQIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHP 298
                                  :||.|  .|.|          |....|:.|.            
  Fly   379 ----------------------KPALY--ESVT----------TDGKDHNINS------------ 397

Human   299 GHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFC 363
                                  :.||.|||:||..:|||.|...::...:..||.| .|..|..|
  Fly   398 ----------------------QVWCQIAYWEMAHRVGEFFHAKTNAVNIYTDGIV-ASEVDSMC 439

Human   364 LGQL----SNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGD 424
            |..|    :.:|  ..:.:||..:|.||.|..: .||||:....:..:||.|..|....     |
  Fly   440 LRDLTPAGNQIH--SVVPKARHTVGLGVTLSLE-NGDVWIYNRGNTTIFVDSPTLSENL-----D 496

Human   425 AVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIP-GPGSVGGIAPAISLSAAA 488
            .|.|:.|...:|.|:..:               |...:....|:.| ||                
  Fly   497 RVCKVMPGYCLKAFETNR---------------AELLSMRDHGHHPMGP---------------- 530

Human   489 GIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHL-HRALQLL 536
               ||...    :::||.||||.||.||.|...|||:|:|. |...|.|
  Fly   531 ---VDYFS----IKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLRXQYL 572

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMAD4NP_005350.1 Mediates interaction with ZBTB7A. /evidence=ECO:0000269|PubMed:25514493 1..322 59/347 (17%)
MH1_SMAD_4 14..138 CDD:199816 40/150 (27%)
Required for interaction with TSC22D1. /evidence=ECO:0000269|PubMed:15881652 44..69 9/40 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 168..194 3/25 (12%)
Pneumo_att_G <176..>281 CDD:114270 16/112 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 236..256 0/19 (0%)
SAD 275..320 3/44 (7%)
MH2_SMAD_4 320..541 CDD:199823 66/223 (30%)
DadNP_001369021.1 MH1_SMAD_6_7 197..329 CDD:199813 39/191 (20%)
MH2_I-SMAD 400..565 CDD:199821 63/211 (30%)

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