DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMAD4 and smad4

DIOPT Version :10

Sequence 1:NP_005350.1 Gene:SMAD4 / 4089 HGNCID:6770 Length:552 Species:Homo sapiens
Sequence 2:XP_002934485.1 Gene:smad4 / 100038088 XenbaseID:XB-GENE-485691 Length:549 Species:Xenopus tropicalis


Alignment Length:551 Identity:506/551 - (91%)
Similarity:525/551 - (95%) Gaps:4/551 - (0%)


- Green bases have known domain annotations that are detailed below.


Human     4 MSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHP 68
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog     1 MSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHP 65

Human    69 SKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHY 133
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog    66 SKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHY 130

Human   134 ERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDF-EGQPSLST-EGHSIQTIQHPPSNRASTETYS 196
            |||||||||||||||||:||||::|||||.||: |||.|:|. :||||||||||||:|||||:||
 Frog   131 ERVVSPGIDLSGLTLQSSAPSSLLVKDEYGHDYAEGQQSISAGDGHSIQTIQHPPSSRASTESYS 195

Human   197 TPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEGLLQIASGPQPGQQQNGFTGQPATYH 261
            .|::|||||.:..:..:|.:|||.|||||||:|..:|::|||.||..|..| .||||||||||||
 Frog   196 NPSMLAPSEPSTPNPTSFSSIPVPSTSQPASLLAATHNDGLLSIAPVPPQG-TQNGFTGQPATYH 259

Human   262 HNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCSI 326
            |||||||||||||.||||:.||.|||||||||| |||||||||||||||||||||||||||||||
 Frog   260 HNSTTTWTGSRTAAYTPNMSHHPNGHLQHHPPM-PHPGHYWPVHNELAFQPPISNHPAPEYWCSI 323

Human   327 AYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLEC 391
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   324 AYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLEC 388

Human   392 KGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQA 456
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   389 KGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQA 453

Human   457 AAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKET 521
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   454 AAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKET 518

Human   522 PCWIEIHLHRALQLLDEVLHTMPIADPQPLD 552
            |||||||||||||||||||||||||||||||
 Frog   519 PCWIEIHLHRALQLLDEVLHTMPIADPQPLD 549

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMAD4NP_005350.1 Mediates interaction with ZBTB7A. /evidence=ECO:0000269|PubMed:25514493 1..322 274/319 (86%)
MH1_SMAD_4 14..138 CDD:199816 123/123 (100%)
Required for interaction with TSC22D1. /evidence=ECO:0000269|PubMed:15881652 44..69 24/24 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 168..194 20/26 (77%)
Pneumo_att_G <176..>281 CDD:114270 74/104 (71%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 236..256 12/19 (63%)
SAD 275..320 39/44 (89%)
MH2_SMAD_4 320..541 CDD:199823 220/220 (100%)
smad4XP_002934485.1 MH1_SMAD_4 11..135 CDD:199816 123/123 (100%)
MH2_SMAD_4 317..538 CDD:199823 220/220 (100%)

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