DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nxf4 and Nxf2

DIOPT Version :9

Sequence 1:	NP_731156.1	Gene:	nxf4 / 40884	FlyBaseID:	FBgn0051501	Length:	301	Species:	Drosophila melanogaster
Sequence 2:	NP_001276664.1	Gene:	Nxf2 / 83454	MGIID:	1933192	Length:	691	Species:	Mus musculus

Alignment Length:	250	Identity:	59/250 - (23%)
Similarity:	103/250 - (41%)	Gaps:	46/250 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 WYRVLIYSTDRRLTFNRVLRRIR--CILTPLKINPRYKHTGGEQDTAEDSWALFTFFVDSYDVAS 105
            ||:|.|.| .|:.....::|.|:  |....:.::..|..|...            |||.:...||
Mouse   125 WYKVTIPS-GRKYEKTWLMRSIQNFCSEPFIPVDFHYDKTQAR------------FFVQNAKTAS 176

  Fly   106 ALFRRGWVDNQIWLKVSD---RMPKIWIN-SILRL------------HLTMVLLDRYDPVERSLD 154
            ||       ..:..::.|   |...|::: |::..            ::...:::|||..:::||
Mouse   177 AL-------KDVSYRICDETSRKIAIFVSPSVVPYSVQNKFTSEQMEYIRESMMNRYDASQKALD 234

  Fly   155 LTLFYKDKALCGE--FFALAESNCMSTVLGIVDREMPELERLILDGNHLTNLWVFRKVERRFPRL 217
            |..|..|:.|..:  ...|...:||...|.|:..::|||..|.|..|.|..|.....:..:.|.:
Mouse   235 LEKFRFDQDLMDKDIDMMLNRRSCMVATLQIIQSDIPELLSLNLTNNKLYQLDGLSDMTEKAPHV 299

  Fly   218 HSISLKHNDIENIYSLRNLQFLPLAELNLLDNPL------PAGYEKEVLDIWPSL 266
            ..::|..|.:::...|..::.|.|.||.|..||.      ...|...:.|::|.|
Mouse   300 KILNLSRNKLKSFTELEKVKELKLEELWLEGNPFCNCFLDHFEYISTIHDLFPKL 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nxf4	NP_731156.1	leucine-rich repeat	150..190	CDD:275382	11/41 (27%)
		LRR_4	189..235	CDD:289563	12/45 (27%)
		leucine-rich repeat	191..216	CDD:275382	6/24 (25%)
		leucine-rich repeat	217..240	CDD:275382	3/22 (14%)
Nxf2	NP_001276664.1	Tap-RNA_bind	123..204	CDD:286271	22/98 (22%)
		leucine-rich repeat	230..272	CDD:275382	11/41 (27%)
		LRR_4	271..317	CDD:289563	12/45 (27%)
		leucine-rich repeat	273..298	CDD:275382	6/24 (25%)
		leucine-rich repeat	299..322	CDD:275382	3/22 (14%)
		leucine-rich repeat	323..353	CDD:275382	8/29 (28%)
		NTF2_like	451..606	CDD:298832
		TAP_C	630..691	CDD:197882
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3763
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810