DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nxf4 and Nxf1

DIOPT Version :9

Sequence 1:	NP_731156.1	Gene:	nxf4 / 40884	FlyBaseID:	FBgn0051501	Length:	301	Species:	Drosophila melanogaster
Sequence 2:	NP_067590.2	Gene:	Nxf1 / 59087	RGDID:	62014	Length:	618	Species:	Rattus norvegicus

Alignment Length:	318	Identity:	68/318 - (21%)
Similarity:	125/318 - (39%)	Gaps:	69/318 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NNSSEGPLCHSTPR-------------------SVKGDFKFESKNGARLPR--SIYGWYRVLI-Y 49
            |:..:||.....|.                   :|:.|...:.:.||...:  :...|:::.| |
  Rat    61 NDPQDGPRVRYNPYTSRPNRRRDTWHDRDRIHVTVRRDRAPQERGGAGTSQDGTTKNWFKITIPY 125

  Fly    50 ST--DRRLTFNRVLRRIRCILTPLKINPRYKHTGGEQDTAEDSWALFTFFVDSYDVASALFRRGW 112
            ..  |:....:.:..:......|::.:  |::|..:            |||:....||||
  Rat   126 GKKYDKMWLLSMIQSKCSVPFNPIEFH--YENTRAQ------------FFVEDATTASAL----- 171

  Fly   113 VDNQIWLKVSDRMPK---IWINSILRLH-------------LTMVLLDRYDPVERSLDLTLFYKD 161
              ..:..|:.||..:   |.|||....:             |.:::..|||..:::|||.....|
  Rat   172 --KAVNYKIQDRENRRISIIINSSAPPYIVQNELKPEQVEQLKLIMSKRYDGSQQALDLKGLRSD 234

  Fly   162 KALCGEFF--ALAESNCMSTVLGIVDREMPELERLILDGNHLTNLWVFRKVERRFPRLHSISLKH 224
            ..|..:..  .|....||:..|.|::..:|||..|.|..|.|..|.....:.::.|.|..::|..
  Rat   235 PDLVAQNIDVVLNRRGCMAAALRIIEENIPELLSLNLSNNRLYKLDDMSSIVQKAPNLKILNLSG 299

  Fly   225 NDIENIYSLRNLQFLPLAELNLLDNPL------PAGYEKEVLDIWPSLQVLNKIQVTP 276
            |::::.:.|..::.|.|.||.|..||:      .:.|...:.:.:|.|..|:..::.|
  Rat   300 NELKSEWELDKIKGLKLEELWLDRNPMCDTFLDQSTYISTIRERFPKLLRLDGHELPP 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nxf4	NP_731156.1	leucine-rich repeat	150..190	CDD:275382	10/41 (24%)
		LRR_4	189..235	CDD:289563	13/45 (29%)
		leucine-rich repeat	191..216	CDD:275382	6/24 (25%)
		leucine-rich repeat	217..240	CDD:275382	4/22 (18%)
Nxf1	NP_067590.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..113		8/51 (16%)
		Interaction with ALYREF/THOC4 and LUZP4. /evidence=ECO:0000250\|UniProtKB:Q9UBU9	2..197		29/156 (19%)
		RNA-binding (RBD). /evidence=ECO:0000250	2..117		8/55 (15%)
		Minor non-specific RNA-binding. /evidence=ECO:0000250	2..59
		Major non-specific RNA-binding. /evidence=ECO:0000250	60..117		8/55 (15%)
		RNA binding. /evidence=ECO:0000250	60..117		8/55 (15%)
		Nuclear localization signal. /evidence=ECO:0000250	66..99		4/32 (13%)
		Nuclear export signal. /evidence=ECO:0000250	82..109		4/26 (15%)
		Tap-RNA_bind	115..197	CDD:401194	21/102 (21%)
		leucine-rich repeat	223..265	CDD:275382	10/41 (24%)
		LRR_8	264..326	CDD:404697	19/61 (31%)
		LRR 1	265..290		7/24 (29%)
		leucine-rich repeat	266..291	CDD:275382	6/24 (25%)
		LRR 2	291..314		4/22 (18%)
		leucine-rich repeat	292..315	CDD:275382	4/22 (18%)
		LRR 3	315..342		7/26 (27%)
		leucine-rich repeat	316..346	CDD:275382	7/29 (24%)
		LRR 4	343..370		4/15 (27%)
		NTF2	381..537	CDD:238403
		TAP_C	555..617	CDD:197882
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3763
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810