DRSC/TRiP Functional Genomics Resources

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Protein Alignment nxf4 and NXF3

DIOPT Version :9

Sequence 1:NP_731156.1 Gene:nxf4 / 40884 FlyBaseID:FBgn0051501 Length:301 Species:Drosophila melanogaster
Sequence 2:NP_071335.1 Gene:NXF3 / 56000 HGNCID:8073 Length:531 Species:Homo sapiens


Alignment Length:206 Identity:32/206 - (15%)
Similarity:73/206 - (35%) Gaps:52/206 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 TPRSVKGDFKFESKNGARLPR----------------SIYGWYRVLI---YSTDRRLTFNRVLRR 63
            :|.:.||.|:.:.:....:.|                ::..|:::.:   ...:.:...|.:...
Human    72 SPYNRKGSFRKQDQTHVNMEREQKPPERRMEGNMPDGTLGSWFKITVPFGIKYNEKWLLNLIQNE 136

  Fly    64 IRCILTPLKINPRYKHTGGEQDTAEDSWALFTFFVDSYDVASALFRRGWVDNQIWLKVSDRMPKI 128
            ......|::.:....|.              :|||::..:|.||..   |..:||.:.:::: .|
Human   137 CSVPFVPVEFHYENMHA--------------SFFVENASIAYALKN---VSGKIWDEDNEKI-SI 183

  Fly   129 WINSILRLH-------------LTMVLLDRYDPVERSLDLTL--FYKDKALCGEFFALAESNCMS 178
            ::|.....|             :.:.:..:.|..:.:||:..  ||.|........|.....||:
Human   184 FVNPAGIPHFVHRELKSEKVEQIKLAMNQQCDVSQEALDIQRLPFYPDMVNRDTKMASNPRKCMA 248

  Fly   179 TVLGIVDREMP 189
            ..|.:.:..:|
Human   249 ASLDVHEENIP 259

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nxf4NP_731156.1 leucine-rich repeat 150..190 CDD:275382 10/42 (24%)
LRR_4 189..235 CDD:289563 1/1 (100%)
leucine-rich repeat 191..216 CDD:275382
leucine-rich repeat 217..240 CDD:275382
NXF3NP_071335.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 33..59
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 83..106 1/22 (5%)
Tap-RNA_bind 110..192 CDD:312616 15/99 (15%)
noncanonical RNP-type RNA-binding (RBD) domain 115..192 14/94 (15%)
leucine-rich repeat (LRR) domains 193..329 11/67 (16%)
leucine-rich repeat 218..260 CDD:275382 10/42 (24%)
leucine-rich repeat 275..305 CDD:275382
nuclear transport factor 2 (NTF2)-like domain 339..461
NTF2 341..496 CDD:238403
ubiquitin-associated domain 524..531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3763
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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