Protein Alignment nxf4 and Nxf1

DIOPT Version :9

• Sequence 1: NP_731156.1
• Gene: nxf4 / 40884
• FlyBaseID: FBgn0051501
• Length: 301
• Species: Drosophila melanogaster
• Sequence 2: NP_058093.2
• Gene: Nxf1 / 53319
• MGIID: 1858330
• Length: 618
• Species: Mus musculus
• Alignment Length: 350
• Identity: 76/350 - (21%)
• Similarity: 133/350 - (38%)
• Gaps: 86/350 - (24%)

  Fly     7 NNSSEGPLCHSTPR-------------------SVKGDFKFESKNGARLPR--SIYGWYRVLI-Y 49
            |:..:||.....|.                   :|:.|.....:.||...:  :...|:::.| |
Mouse    61 NDPQDGPRVRYNPYTNRPNRRGDGWHDRDRIHITVRRDRAPAERGGAGTSQDGTTKNWFKITIPY 125

  Fly    50 STDRRLTFNRVLRRIRCILTPLKINPRYKHTGGEQDTAEDSWALFTFFVDSYDVASALFRRGWVD 114
            ......|:...:.:.:|.:....|...|::|...            |||:....||||  :| |:
Mouse   126 GRKYDKTWLLSMIQSKCSVPFNPIEFHYENTRAH------------FFVEDATTASAL--KG-VN 175

  Fly   115 NQIWLKVSDR------------MPKIWINSILR----LHLTMVLLDRYDPVERSLDLTLFYKDKA 163
            :    |:.||            .|...:.:.|:    ..|.:::..|||..:::|||.....|..
Mouse   176 H----KIQDRENRRISIIINASAPPYTVQNELKPEQIEQLKLIMSKRYDGNQQALDLKGLRSDPD 236

  Fly   164 LCGEFF--ALAESNCMSTVLGIVDREMPELERLILDGNHLTNLWVFRKVERRFPRLHSISLKHND 226
            |..:..  .|...:||:..|.|::..:|||..|.|..|.|..|.....:.::.|.|.:::|..|:
Mouse   237 LVAQNIDVVLNRRSCMAATLRIIEENIPELLSLNLSSNRLYKLDDMSSIVQKAPNLKTLNLSGNE 301

  Fly   227 IENIYSLRNLQFLPLAELNLLDNPL------PAGYEKEVLDIWPSLQVLNKIQVTPD-------P 278
            ::....|..::.|.|.||.|..||:      .:.|...:.:.:|.|..|:..::.|.       |
Mouse   302 LKTERELDKIKGLKLEELWLDRNPMCDNFGDQSSYISAIRERFPKLLRLDGHELPPPISFDVEAP 366

  Fly   279 AMM--------------QLVERVLQ 289
            .|:              .||.|.||
Mouse   367 TMLPPCKGSYFGTENLKSLVLRFLQ 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nxf4	NP_731156.1	leucine-rich repeat	150..190	CDD:275382	10/41 (24%)
		LRR_4	189..235	CDD:289563	13/45 (29%)
		leucine-rich repeat	191..216	CDD:275382	6/24 (25%)
		leucine-rich repeat	217..240	CDD:275382	4/22 (18%)
Nxf1	NP_058093.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..113		8/51 (16%)
		Interaction with ALYREF/THOC4 and LUZP4. /evidence=ECO:0000250|UniProtKB:Q9UBU9	2..197		29/154 (19%)
		RNA-binding (RBD). /evidence=ECO:0000250	2..117		8/55 (15%)
		Minor non-specific RNA-binding. /evidence=ECO:0000250	2..59
		Major non-specific RNA-binding. /evidence=ECO:0000250	60..117		8/55 (15%)
		RNA binding. /evidence=ECO:0000250	60..117		8/55 (15%)
		Nuclear localization signal. /evidence=ECO:0000250	66..99		4/32 (13%)
		Nuclear export signal. /evidence=ECO:0000250	82..109		4/26 (15%)
		Tap-RNA_bind	115..197	CDD:286271	21/100 (21%)
		leucine-rich repeat	223..265	CDD:275382	10/41 (24%)
		LRR_8	264..326	CDD:290566	19/61 (31%)
		LRR 1	265..290		7/24 (29%)
		leucine-rich repeat	266..291	CDD:275382	6/24 (25%)
		LRR_4	290..328	CDD:289563	12/37 (32%)
		LRR 2	291..314		4/22 (18%)
		leucine-rich repeat	292..315	CDD:275382	4/22 (18%)
		LRR 3	315..342		7/26 (27%)
		leucine-rich repeat	316..346	CDD:275382	7/29 (24%)
		LRR 4	343..370		6/26 (23%)
		NTF2	381..537	CDD:238403	4/10 (40%)
		TAP_C	555..617	CDD:197882

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3763
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810