Protein Alignment SMAD3 and Dad

DIOPT Version :10

• Sequence 1: NP_001393940.1
• Gene: SMAD3 / 4088
• HGNCID: 6769
• Length: 462
• Species: Homo sapiens
• Sequence 2: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Alignment Length: 429
• Identity: 108/429 - (25%)
• Similarity: 164/429 - (38%)
• Gaps: 126/429 - (29%)

Human    34 AVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLH 98
            ||||.:....|| |.|.:|...||.....:||.||.......:       |||...||:.|.:|.
  Fly   239 AVKSRLDPPTKT-QRDVVEPTTTTAPTYLQCILIPCKTQTVWE-------PHVTASRLFFWRELW 295

Human    99 SHHELRAMELCEFAFNMKKD--EVCVNPYHYQRV------ETPVLPPVL-----------VPRHT 144
            :..||:.:..|..|    :|  .:|.||.|:.|:      |:|. ||..           ....:
  Fly   296 NAKELKRLPTCPAA----RDCIYMCCNPLHWFRILHQPETESPT-PPYQRSKMLRLKDADFEEDS 355

Human   145 EIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSP 209
            :..|:...|..:|   .|:|:.       |||.:  |..|.|...:..||.:|..:
  Fly   356 QNDAKSAALSTWS---AESTSI-------SNIYK--PALYESVTTDGKDHNINSQV--------- 399

Human   210 NPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTD---PSNSERFCL 271
                                  ||.|:|:|:..||||.|||...::.:  :||   .|..:..||
  Fly   400 ----------------------WCQIAYWEMAHRVGEFFHAKTNAVNI--YTDGIVASEVDSMCL 440

Human   272 GLLSNVNR--NAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKI 334
            ..|:....  ::.|...|..:|.||.|....|:|:.....::.|||.||..::...    .|||:
  Fly   441 RDLTPAGNQIHSVVPKARHTVGLGVTLSLENGDVWIYNRGNTTIFVDSPTLSENLD----RVCKV 501

Human   335 PPGKAPLSTPSPYFWKPSLQTSPCSGSRSLWASLPSPLAGCNLKIFNNQEFAALLAQSVNQGFEA 399
            .||..                                     ||.|.... |.||:.. :.|...
  Fly   502 MPGYC-------------------------------------LKAFETNR-AELLSMR-DHGHHP 527

Human   400 VYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLN 438
            :..:... :|::||.||||.:|:||.:...|||:|:|.:
  Fly   528 MGPVDYF-SIKISFGKGWGRDYKRQDIMGCPCWLEVHFS 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMAD3	NP_001393940.1	MH1_SMAD_2_3	8..132	CDD:199815	32/105 (30%)
		MH2	224..451	CDD:469593	58/220 (26%)
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	32/101 (32%)
		MH2_I-SMAD	400..565	CDD:199821	58/210 (28%)