Protein Alignment SMAD3 and Mad

DIOPT Version :9

• Sequence 1: NP_005893.1
• Gene: SMAD3 / 4088
• HGNCID: 6769
• Length: 425
• Species: Homo sapiens
• Sequence 2: NP_001259992.1
• Gene: Mad / 33529
• FlyBaseID: FBgn0011648
• Length: 525
• Species: Drosophila melanogaster
• Alignment Length: 459
• Identity: 280/459 - (61%)
• Similarity: 335/459 - (72%)
• Gaps: 54/459 - (11%)

Human     1 MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKK-TGQLDELEKAITTQNVNTKC 64
            :.|:..||.|.||:|||||:|:   :||||.||||.|||||||| .|.::|||:|::.....:||
  Fly    87 LGSLFSFTSPAVKKLLGWKQGD---EEEKWAEKAVDSLVKKLKKRKGAIEELERALSCPGQPSKC 148

Human    65 ITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQR 129
            :|||||||||||||||||||||||||:||||||.|||||:.:|||::.|:.|:.|||:|||||:|
  Fly   149 VTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYKR 213

Human   130 VETPVLPPVLVPRHTEIPAEFPP---LDDYSH----SIPENTNF-------------------PA 168
            ||:|||||||||||    :||.|   :..::|    |:|.|.::                   |:
  Fly   214 VESPVLPPVLVPRH----SEFAPGHSMLQFNHVAEPSMPHNVSYSNSGFNSHSLSTSNTSVGSPS 274

Human   169 GIEPQSNIP-----ETPPPGYL-SEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYC 227
            .:....|.|     .||||.|. ||||.:     |:..|.|  .|....|.      |:..|:|.
  Fly   275 SVNSNPNSPYDSLAGTPPPAYSPSEDGNS-----NNPNDGG--QLLDAQMG------DVAQVSYS 326

Human   228 EPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPS-NSERFCLGLLSNVNRNAAVELTRRHIG 291
            |||||.||:|||||.||||.||.:..|:.|||||:|| ||:|.|||.|||||||:.:|.||||||
  Fly   327 EPAFWASIAYYELNCRVGEVFHCNNNSVIVDGFTNPSNNSDRCCLGQLSNVNRNSTIENTRRHIG 391

Human   292 RGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSV 356
            :||.|||:.|||:|||||||||||||.|||..:|:||:|||||||||:||||||||||.||:|||
  Fly   392 KGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIFNNQEFAQLLSQSV 456

Human   357 NQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRC 421
            |.||||||:||:||||||||||||||||.||.|||||||||:||:||||||||||||||||....
  Fly   457 NNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNAI 521

Human   422 SSVS 425
            ||||
  Fly   522 SSVS 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMAD3	NP_005893.1	MH1_SMAD_2_3	8..132	CDD:199815	84/124 (68%)
		Linker	137..231		36/125 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..208		15/67 (22%)
		MH2_SMAD_2_3	224..414	CDD:199826	148/190 (78%)
		Sufficient for interaction with XPO4. /evidence=ECO:0000269|PubMed:16449645	271..324		40/52 (77%)
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	85/125 (68%)
		MH2_SMAD_1_5_9	325..525	CDD:199822	154/199 (77%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274383at33208
OrthoFinder	1	1.000	-	-		FOG0000630
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X373
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820