DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMAD3 and Smox

DIOPT Version :9

Sequence 1:	NP_005893.1	Gene:	SMAD3 / 4088	HGNCID:	6769	Length:	425	Species:	Homo sapiens
Sequence 2:	NP_001285006.1	Gene:	Smox / 31738	FlyBaseID:	FBgn0025800	Length:	486	Species:	Drosophila melanogaster

Alignment Length:	499	Identity:	301/499 - (60%)
Similarity:	348/499 - (69%)	Gaps:	90/499 - (18%)

- Green bases have known domain annotations that are detailed below.

Human     4 ILPFTPPIVKRLLGWKKG-EQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITI 67
            :|||||.:|||||..||| |.|..|.||.|||||:||||:||..||:|||:||:|||..|:|:|:
  Fly     1 MLPFTPQVVKRLLALKKGNEDNSVEGKWSEKAVKNLVKKIKKNSQLEELERAISTQNCQTRCVTV 65

Human    68 PRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVET 132
            |||.........||||||||||||||||||.|.:||:.::.||:||:::|:|:|:|||||:::|.
  Fly    66 PRSKPAPAGEHLRKGLPHVIYCRLWRWPDLQSQNELKPLDHCEYAFHLRKEEICINPYHYKKIEL 130

Human   133 PVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGI-------EPQ----------------- 173
            .:|.|..:|...:...:: |||:::|.||.||::.|.|       .||
  Fly   131 SILVPKSLPTPPDSIVDY-PLDNHTHQIPNNTDYNAAIIRSASLSPPQYMELGGAGPVSVSSSAS 194

Human   174 --------------------------------------------------SNIPE--TPPPGYLS 186
                                                              |:||.  ||||||:|
  Fly   195 STPATAAGGGGGPSSSSSSSSSAASAYQQQQQQLSFGQNMDSQSSVLSVGSSIPNTGTPPPGYMS 259

Human   187 EDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHAS 251
            |||:..|...|.:|...:|        ||    |..||.|.||||||||||||||.|||||||||
  Fly   260 EDGDPIDPNDNMNMSRLTP--------PA----DAAPVMYHEPAFWCSISYYELNTRVGETFHAS 312

Human   252 QPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQ 316
            |||:|||||||||||||||||||||||||..||.||||||:|||||||||||||||||||:||||
  Fly   313 QPSITVDGFTDPSNSERFCLGLLSNVNRNEVVEQTRRHIGKGVRLYYIGGEVFAECLSDSSIFVQ 377

Human   317 SPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWG 381
            ||||||||||||||||||||||||||||||||||||:|||:||||||||||||||||||||||||
  Fly   378 SPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLSQSVSQGFEAVYQLTRMCTIRMSFVKGWG 442

Human   382 AEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 425
            |||||||||||||||||||||||||||:||||||||.:.|||:|
  Fly   443 AEYRRQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPRLPCSSMS 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMAD3	NP_005893.1	MH1_SMAD_2_3	8..132	CDD:199815	75/124 (60%)
		Linker	137..231		39/169 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..208		21/118 (18%)
		MH2_SMAD_2_3	224..414	CDD:199826	177/189 (94%)
		Sufficient for interaction with XPO4. /evidence=ECO:0000269\|PubMed:16449645	271..324		47/52 (90%)
Smox	NP_001285006.1	MH1_R-SMAD	7..130	CDD:199812	73/122 (60%)
Smox	NP_001285006.1	MH2_SMAD_2_3	285..475	CDD:199826	177/189 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	348	1.000	Domainoid score	I1034
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55937
Inparanoid	1	1.050	578	1.000	Inparanoid score	I1032
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48607
OrthoDB	1	1.010	-	-		D274383at33208
OrthoFinder	1	1.000	-	-		FOG0000630
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104703
Panther	1	1.100	-	-	LDO	PTHR13703
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5017
SonicParanoid	1	1.000	-	-		X373
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870