DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rn and znf362a

DIOPT Version :9

Sequence 1:	NP_001262343.1	Gene:	rn / 40879	FlyBaseID:	FBgn0267337	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_001071201.1	Gene:	znf362a / 777625	ZFINID:	ZDB-GENE-061103-547	Length:	448	Species:	Danio rerio

Alignment Length:	521	Identity:	170/521 - (32%)
Similarity:	234/521 - (44%)	Gaps:	124/521 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 KPHNNNGYSWSTGNNNEVVSHSSNGHTNNHPTTPPTPPNEASATQATSVSAINLNQAQPASQTRS 222
            :|..||.|.|                        |.||:...  |..::..||..:.|..::
Zfish     3 EPRFNNPYFW------------------------PPPPSIPG--QLDNLVLINKIKEQLMAE--- 38

  Fly   223 NFGSSIKSPPSEPDAV---------TAATCKSQENNSGQNPTPNSLSDHNPAHNLNSNSTAAAVA 278
                .|:.|..:|.:|         :|.|...|.|.|    || .|......|...::....|:.
Zfish    39 ----KIRPPHLQPTSVPSQQPLLVPSAGTEGGQHNIS----TP-KLQQMPGLHAHGTSQPDIALH 94

  Fly   279 AAAAAAAAANMPIGGVQGQNPTQGLVHWMSAVMAEHMTGQTHHDPGAVGMHYMWNGNVDHAKDIS 343
            |..|:::.....:|.|                                      |.|:|....|.
Zfish    95 ARPASSSVTGRILGDV--------------------------------------NLNLDDKTAIK 121

  Fly   344 DYNLWPPTPRSHQHASEHHPMSLKQEYEAKMNDHHHNNLQKGHFLDDNRLEHHAVT--------- 399
            ...||          .:.|   |:|..:.....:|.:.|......:.|.....:||
Zfish   122 ARGLW----------EDWH---LRQIIDQPSRANHLSGLSLASSRNANHNTSESVTPSTPTSPTI 173

  Fly   400 -GQGGLGLGASNGVGG--GGGGASVVGNSSLGASSHHAVAAAHHHNQAVAAASAAA-LLVVPQPI 460
             ||...|:..:|.:.|  ||.|...:.||  ||.....:.:.....:.:.|.:.:. |||||.||
Zfish   174 GGQSRQGIPTANLLSGLTGGPGMEALKNS--GALMGPPMKSIGRGRKKIKAENTSGPLLVVPYPI 236

  Fly   461 NASKMGGPGGVSSVAGGHATGGGSGRKYQCKMCPQIFSSKADLQLHTQIHMREAKPYKCTQCSKA 525
            .||      |....|   ......|:.|:||:||..|.||:|:|:|::.| .||||:||..|:|.
Zfish   237 LAS------GAEQSA---VITAKEGKTYRCKVCPLTFFSKSDMQIHSKSH-TEAKPHKCPHCTKT 291

  Fly   526 FANSSYLSQHTRIHLGIKPYRCEICQRKFTQLSHLQQHIRTHTGDKPYKCRHPGCQKAFSQLSNL 590
            |||:|||:||.|||||:|||.|..|::.|.||||||||.|.||||:||||..|||:|||:|||||
Zfish   292 FANASYLAQHLRIHLGVKPYHCSYCEKSFRQLSHLQQHTRIHTGDRPYKCLQPGCEKAFTQLSNL 356

  Fly   591 QSHSRCHQTDKPFKCNSCYKCFSDEPSLLEHIPKHKESKHLKTHICQYCGKSYTQETYLTKHMQK 655
            |||.|.|..|||:||::||:.:||..||..|:..| ..|:.|.:.|..||::||.||||.|||.|
Zfish   357 QSHQRSHNKDKPYKCSNCYRAYSDSASLQIHLSAH-AIKNAKAYCCSMCGRAYTSETYLMKHMSK 420

  Fly   656 H 656
            |
Zfish   421 H 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rn	NP_001262343.1	C2H2 Zn finger	490..510	CDD:275368	10/19 (53%)
		C2H2 Zn finger	519..539	CDD:275368	12/19 (63%)
		zf-H2C2_2	531..556	CDD:290200	15/24 (63%)
		zf-C2H2	545..567	CDD:278523	13/21 (62%)
		C2H2 Zn finger	547..567	CDD:275368	12/19 (63%)
		zf-C2H2_8	550..630	CDD:292531	48/79 (61%)
		zf-H2C2_2	559..586	CDD:290200	20/26 (77%)
		C2H2 Zn finger	575..597	CDD:275368	16/21 (76%)
		C2H2 Zn finger	605..625	CDD:275368	8/19 (42%)
		C2H2 Zn finger	636..656	CDD:275368	12/19 (63%)
znf362a	NP_001071201.1	C2H2 Zn finger	257..277	CDD:275368	10/19 (53%)
		zf-H2C2_2	269..294	CDD:290200	13/25 (52%)
		C2H2 Zn finger	285..305	CDD:275368	12/19 (63%)
		zf-H2C2_2	297..322	CDD:290200	15/24 (63%)
		COG5048	309..>403	CDD:227381	55/94 (59%)
		C2H2 Zn finger	313..333	CDD:275368	12/19 (63%)
		zf-H2C2_2	325..352	CDD:290200	20/26 (77%)
		C2H2 Zn finger	341..363	CDD:275368	16/21 (76%)
		zf-H2C2_2	355..379	CDD:290200	14/23 (61%)
		C2H2 Zn finger	371..391	CDD:275368	8/19 (42%)
		C2H2 Zn finger	401..421	CDD:275368	12/19 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	43	1.000	Domainoid score	I12363
eggNOG	1	0.900	-	-		E33208_3BF42
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26399
orthoMCL	1	0.900	-	-		OOG6_109421
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3082
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.740