DRSC/TRiP Functional Genomics Resources

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Protein Alignment rn and ZNF135

DIOPT Version :10

Sequence 1:NP_001262343.1 Gene:rn / 40879 FlyBaseID:FBgn0267337 Length:952 Species:Drosophila melanogaster
Sequence 2:NP_009065.1 Gene:ZNF135 / 7694 HGNCID:12919 Length:682 Species:Homo sapiens


Alignment Length:659 Identity:159/659 - (24%)
Similarity:224/659 - (33%) Gaps:207/659 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   114 SSATPLLPSP---PIKIEQ----VFGEPSSLGAVVEDYALGLDCPVEHTFRKPHNNNGYSWSTGN 171
            |.|.|:..:|   |: :||    .|||..||..         |.|  |....|...:.::|.|..
Human   166 SLAVPVAFTPVKTPV-LEQWQRNGFGENISLNP---------DLP--HQPMTPERQSPHTWGTRG 218

  Fly   172 NNE------------------------VVSHSSN--GHTNNHPTTPPTPPNEASATQATSVSAIN 210
            ..|                        ..||||.  .|...|....|...:|.......| ||:.
Human   219 KREKPDLNVLQKTCVKEKPYKCQECGKAFSHSSALIEHHRTHTGERPYECHECLKGFRNS-SALT 282

  Fly   211 LNQ-----AQPASQTRSNFGSSIKSPPSEPDAVTAATCKSQENNSGQNPTP-----------NSL 259
            .:|     .:|...|:.  |.:...        .|...:.|..::|:.|..           :|.
Human   283 KHQRIHTGEKPYKCTQC--GRTFNQ--------IAPLIQHQRTHTGEKPYECSECGKSFSFRSSF 337

  Fly   260 SDHNPAHNLNSNSTAAAVAAAAAAAAAANMPIGGVQGQNPTQ----GLVHWMSAVMAEHM---TG 317
            |.|...|.                            |:.|.:    |.....|..:.:|:   ||
Human   338 SQHERTHT----------------------------GEKPYECSECGKAFRQSIHLTQHLRIHTG 374

  Fly   318 QTHHDPGAVGMHYMWNGNVDHAKDISDYNLWPPTPRSHQ--HASEHHPMSLKQEYEAKMNDHHHN 380
            :..:..|..|..:      .|:..::          .||  |..|       :.||.    |...
Human   375 EKPYQCGECGKAF------SHSSSLT----------KHQRIHTGE-------KPYEC----HECG 412

  Fly   381 NLQKGHFLDDNRLEHHAVTGQGGLGLGASNGVGGGGGGASVVGNSSLGASSHHAVAAAHHHNQAV 445
            ..    |.....|..|..|                                 |.....:...:..
Human   413 KA----FTQITPLIQHQRT---------------------------------HTGEKPYECGECG 440

  Fly   446 AAASAAALLVV-------PQPINASKMGGPGGVSSVAGGHATGGGSGRKYQCKMCPQIFSSKADL 503
            .|.|.:.||..       .:|...::.|.....||....|.......:.|:|..|.:.|.....|
Human   441 KAFSQSTLLTEHRRIHTGEKPYGCNECGKTFSHSSSLSQHERTHTGEKPYECSQCGKAFRQSTHL 505

  Fly   504 QLHTQIHMREAKPYKCTQCSKAFANSSYLSQHTRIHLGIKPYRCEICQRKFTQLSHLQQHIRTHT 568
            ..|.:||..| |||:|..|.|||::||.|::|.|||.|.|||.|..|.|.|:||:.|.||.|.||
Human   506 TQHQRIHTGE-KPYECNDCGKAFSHSSSLTKHQRIHTGEKPYECNQCGRAFSQLAPLIQHQRIHT 569

  Fly   569 GDKPYKCRHPGCQKAFSQLSNLQSHSRCHQTDKPFKCNSCYKCFSDEPSLLEHIPKHKESKHLKT 633
            |:|||:|..  |.:||||.|.|..|.|.|..:||:.||.|.|.||...||.:|...|...   |.
Human   570 GEKPYECNQ--CGRAFSQSSLLIEHQRIHTKEKPYGCNECGKSFSHSSSLSQHERTHTGE---KP 629

  Fly   634 HICQYCGKSYTQETYLTKHMQKHAERTDKRPPIVPGSAAAIAAAAAAAAGGSANPANGPPPPPNP 698
            :.|..||||:.|.|:||:|.:.|   |.::|........|...:::.                  
Human   630 YECHDCGKSFRQSTHLTQHRRIH---TGEKPYACRDCGKAFTHSSSL------------------ 673

  Fly   699 AQHQRNNLG 707
            .:|||.:.|
Human   674 TKHQRTHTG 682

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rnNP_001262343.1 C2H2 Zn finger 490..510 CDD:275368 5/19 (26%)
C2H2 Zn finger 519..539 CDD:275368 10/19 (53%)
COG5048 543..>647 CDD:227381 49/103 (48%)
C2H2 Zn finger 547..567 CDD:275368 10/19 (53%)
zf-H2C2_2 559..586 CDD:463886 14/26 (54%)
C2H2 Zn finger 575..597 CDD:275368 10/21 (48%)
C2H2 Zn finger 605..625 CDD:275368 9/19 (47%)
C2H2 Zn finger 636..656 CDD:275368 10/19 (53%)
ZNF135NP_009065.1 KRAB 26..85 CDD:214630
zf-C2H2 238..260 CDD:395048 5/21 (24%)
C2H2 Zn finger 240..260 CDD:275368 5/19 (26%)
COG5048 264..665 CDD:227381 129/512 (25%)
C2H2 Zn finger 268..288 CDD:275368 5/20 (25%)
C2H2 Zn finger 296..316 CDD:275368 4/29 (14%)
C2H2 Zn finger 324..344 CDD:275368 3/19 (16%)
C2H2 Zn finger 352..372 CDD:275368 3/19 (16%)
C2H2 Zn finger 380..400 CDD:275368 5/35 (14%)
C2H2 Zn finger 408..428 CDD:275368 5/60 (8%)
C2H2 Zn finger 436..456 CDD:275368 4/19 (21%)
C2H2 Zn finger 464..484 CDD:275368 4/19 (21%)
C2H2 Zn finger 492..512 CDD:275368 5/19 (26%)
C2H2 Zn finger 520..540 CDD:275368 10/19 (53%)
C2H2 Zn finger 548..568 CDD:275368 10/19 (53%)
C2H2 Zn finger 576..596 CDD:275368 10/21 (48%)
C2H2 Zn finger 604..624 CDD:275368 9/19 (47%)
C2H2 Zn finger 632..652 CDD:275368 10/19 (53%)
zf-C2H2 658..680 CDD:395048 4/39 (10%)
C2H2 Zn finger 660..680 CDD:275368 4/37 (11%)
Blue background indicates that the domain is not in the aligned region.

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