DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rn and MAZ

DIOPT Version :9

Sequence 1:	NP_001262343.1	Gene:	rn / 40879	FlyBaseID:	FBgn0267337	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_001036004.1	Gene:	MAZ / 4150	HGNCID:	6914	Length:	493	Species:	Homo sapiens

Alignment Length:	720	Identity:	156/720 - (21%)
Similarity:	225/720 - (31%)	Gaps:	325/720 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 PYHDGHVQGP-----------------------ATPTPCTAPPTPCNGPVPVSVPVSIPVCHTGG 85
            |...||.|.|                       |.|.|   ||||   ..|.:.|:.:.:.
Human    32 PPPQGHAQNPLQVGAELQSRFFASQGCAQSPFQAAPAP---PPTP---QAPAAEPLQVDLL---- 86

  Fly    86 QGSPVIVESSFAIAAAAAAAAAAVAVGGSSATPLLPSPPIKIEQVFGEPSSLGAVVEDYALGLDC 150
               ||:..:..:.||||||||||.||   :|.|  |:|            :..:.|:..||
Human    87 ---PVLAAAQESAAAAAAAAAAAAAV---AAAP--PAP------------AAASTVDTAAL---- 127

  Fly   151 PVEHTFRKPHNNNGYSWSTGNNNEVVSHSSNGHTNNHPTTPPTPPNEASATQATSVSAINLNQAQ 215
                                               ..|..||.||...||
Human   128 -----------------------------------KQPPAPPPPPPPVSA--------------- 142

  Fly   216 PASQTRSNFGSSIKSPPSEPDAVTAATCKSQENNSGQNPTPNSLSDHNPAHNLNSNSTAAAVAAA 280
            ||::.         :||:                                    |.:|.||.||.
Human   143 PAAEA---------APPA------------------------------------SAATIAAAAAT 162

  Fly   281 AAAAAAANMPIGGVQG--QNPTQGLVHWMSAVMAEHMTGQTHHDPGAVGMHYMWNGNVDHAKDIS 343
            |..|..:.:.:..|..  :..|:....::.|:.|:...                ||
Human   163 AVVAPTSTVAVAPVASALEKKTKSKGPYICALCAKEFK----------------NG--------- 202

  Fly   344 DYNLWPPTPRSHQHASEHHPMSLKQEYEAKMNDHHHNNLQKGHFLDDNRLEHHAVTGQGGLGLGA 408
             |||     |.|:..                    |...:.|. :....::...:.....|.:..
Human   203 -YNL-----RRHEAI--------------------HTGAKAGR-VPSGAMKMPTMVPLSLLSVPQ 240

  Fly   409 SNGVGGGGGGASVVGNSSLGASSHHAVAAAHHHNQAVAAASAAALLVVPQPINASKMGGPGGVSS 473
            .:|.|||||.|                                              |..||.::
Human   241 LSGAGGGGGEA----------------------------------------------GAGGGAAA 259

  Fly   474 V-AGGHATGGGSGRKYQCKMCPQIFSSKADLQLHTQIHMREAKPYKCTQCSKAFANSSYLSQHTR 537
            | |||..|...||::.:                         |.:.|..|.|||.:..:|::|..
Human   260 VAAGGVVTTTASGKRIR-------------------------KNHACEMCGKAFRDVYHLNRHKL 299

  Fly   538 IHLGIKPYRCEICQRKFTQLSHLQQHIRTHTG--DKPYKCRHPGCQKAFSQLSNLQSHSR-CHQT 599
            .|...|||:|.:||::|.:...:..|:|:|.|  .|||.|.|  |.|:||:..:|.||.| .|.|
Human   300 SHSDEKPYQCPVCQQRFKRKDRMSYHVRSHDGAVHKPYNCSH--CGKSFSRPDHLNSHVRQVHST 362

  Fly   600 DKPFKCNSCYKCFSDEPSLLEHIPKHKE----------------SKHLKT------HICQYCGKS 642
            ::||||..|...|:.:..|..|..:|:|                |.|:|.      |:|:.|.|.
Human   363 ERPFKCEKCEAAFATKDRLRAHTVRHEEKVPCHVCGKMLSSAYISDHMKVHSQGPHHVCELCNKG 427

  Fly   643 YTQETYLTKHMQK----HAERTDK----------RPPIVPGSAAAIAAAAAAAAGGSANPANGPP 693
            :|...||..|..|    .|.|.|:          :.|      |.:|.......||:|.|..|..
Human   428 FTTAAYLRIHAVKDHGLQAPRADRILCKLCSVHCKTP------AQLAGHMQTHLGGAAPPVPGDA 486

  Fly   694 PPPNP 698
            |.|.|
Human   487 PQPQP 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rn	NP_001262343.1	C2H2 Zn finger	490..510	CDD:275368	0/19 (0%)
		C2H2 Zn finger	519..539	CDD:275368	7/19 (37%)
		zf-H2C2_2	531..556	CDD:290200	10/24 (42%)
		zf-C2H2	545..567	CDD:278523	7/21 (33%)
		C2H2 Zn finger	547..567	CDD:275368	6/19 (32%)
		zf-C2H2_8	550..630	CDD:292531	33/98 (34%)
		zf-H2C2_2	559..586	CDD:290200	12/28 (43%)
		C2H2 Zn finger	575..597	CDD:275368	10/22 (45%)
		C2H2 Zn finger	605..625	CDD:275368	5/19 (26%)
		C2H2 Zn finger	636..656	CDD:275368	8/23 (35%)
MAZ	NP_001036004.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..78		8/24 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..146		12/78 (15%)
		C2H2 Zn finger	192..212	CDD:275368	9/70 (13%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		SFP1	<303..360	CDD:227516	24/58 (41%)
		C2H2 Zn finger	309..329	CDD:275368	6/19 (32%)
		C2H2 Zn finger	339..357	CDD:275368	9/19 (47%)
		C2H2 Zn finger	368..388	CDD:275368	5/19 (26%)
		C2H2 Zn finger	394..413	CDD:275368	3/18 (17%)
		C2H2 Zn finger	421..437	CDD:275368	6/15 (40%)
		C2H2 Zn finger	454..474	CDD:275368	3/25 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	160	1.000	Inparanoid score	I4252
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050