DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rn and crol

DIOPT Version :9

Sequence 1:	NP_001262343.1	Gene:	rn / 40879	FlyBaseID:	FBgn0267337	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster

Alignment Length:	1086	Identity:	249/1086 - (22%)
Similarity:	339/1086 - (31%)	Gaps:	360/1086 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PQLAHHPHSNPHNSSHGHSDYHQFRSYPSFVVTPYHD--GHVQGPATPTPCTA------PPTPCN 67
            |.|....|.......||...|.......|.:.| ||:  |.:.|........|      ||.|..
  Fly    31 PPLPKSEHKEDGKPPHGIEMYKVNIEDISQLFT-YHEVFGKIHGDVVNHQLAAAHGGQLPPPPPL 94

  Fly    68 GPVPVSVPVSIPVCHTGGQGSPVIVESSFAIAAAAAAAAAAVAVGGS--SATPLLPSPPIKIEQV 130
            .|...|...|..........:...|.:..|.|.||||||||.:.||.  .||.......:.:...
  Fly    95 PPQVTSHAASAAAAAAAASTNNAAVAAVMASANAAAAAAAAASAGGGLPPATSGNGGQQVTVTTT 159

  Fly   131 FGEPSSLGAVVEDYALGLDCPVEHTFRKPHNNNGYSWSTGNNNEVVSHSSNGHTNNHPTTPPTPP 195
            ....||.|:...    |...........|....|.....|:.|     ..||...|....|...|
  Fly   160 SSSTSSGGSTTS----GGTTTTAGELLMPKMEGGIHGVDGSGN-----GGNGGGQNVALAPDGTP 215

  Fly   196 NEASATQATSVSAINL------------------------NQAQPASQTRSNFGS-SIKSPPSEP 235
             .|:.|....:.....                        .|....||..:..|. .|..|
  Fly   216 -IATGTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGP---- 275

  Fly   236 DAVTAATCKSQENNSGQNPTPNSLSDHNPAHNLNSNSTAAAVAAAAAAAAAANMPIGGVQGQNPT 300
             ..|...|.:...|:      .||..|...|:.:............|.....:.......|:.|.
  Fly   276 -MFTCIVCFNVFANN------TSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPF 333

  Fly   301 QGLVHWMSAVMAEHM-------TGQTHHDPGAVGM----------HYMWN-GNVDHAKDISDYNL 347
            :......:....|||       ||:|.|.......          ||||: |...|..|:.....
  Fly   334 RCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKY 398

  Fly   348 WPPTPRSH--QHASEH-HPMSLKQEYEAK---MNDHHHNNL-------------------QKGHF 387
               |.:.|  .|...| :....:.|...|   ..:|..|::                   :|.|.
  Fly   399 ---TRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHL 460

  Fly   388 LDDNRLEHHAVTGQGGLGLGASNGVGGGGGGASVVGNSSLGASSHHAVAAAHHHNQAVAAASAAA 452
            |  |.:..|  ||:                                   :.|..:..:...:...
  Fly   461 L--NHVRQH--TGE-----------------------------------SPHRCSYCMKTFTRKE 486

  Fly   453 LLVVPQPINASKMGGPGGVSSVAGGHATGGGSGRKYQCKMCPQIFSSKADLQLHTQIHMREAKPY 517
            .||                     .|.........::|..|.:.|:.|..:..|.:.|..|: |:
  Fly   487 HLV---------------------NHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGES-PH 529

  Fly   518 KCTQCSKAFANSSYLSQHTRIHLGIKPYRCEICQRKFTQLSHLQQHIRTHTGDKPYKCRHPGCQK 582
            |||.|:|.|....:|:.|.|.|.|..|:||..|::.||:..||..|:|.||||.|:||.:  |||
  Fly   530 KCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEY--CQK 592

  Fly   583 AFSQLSNLQSH-----------------------------SRCHQTDKPFKCNSCYKCFSDEPSL 618
            .|::..:|.:|                             ||||..|:||.|.:|.|.|..:.:|
  Fly   593 TFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNL 657

  Fly   619 LEHIPKHKESK-------------------HL----------KTHICQYCGKSYTQETYLTKHMQ 654
            |.|...|.:.:                   ||          |.|.|..|.|::.:...|.:||:
  Fly   658 LFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMK 722

  Fly   655 -KHAE----------------------RTDKRPPIVPGSAA-----AIAAAAAAAAGGSANPANG 691
             .|.:                      :.:.:|.|:|..:|     .|....|.||||:......
  Fly   723 MNHPDAMMPPPPVHPHPQIPAGVLTQVKQEVKPIIIPHHSATTTMHTIQQITAGAAGGAGAVQLT 787

  Fly   692 PPPPP---------NPAQHQRNNLGLPPVSIAPSDNGYWPKVSPDSAAAANAME--------VMH 739
            |...|         |.|..|::.......:.|         ....:||||.|.:        ..|
  Fly   788 PGLVPLVTSTLISHNAAAQQQSQKQQAAAAAA---------AQQQAAAAAAAQQQAAQQQAAAAH 843

  Fly   740 QQQQQQ-----QQQ------QQQQQQQQQQQQ------QQAHHHHPQHGVPPQQHVPPQQQQQQQ 787
            ||.|||     |||      ||||||.|||||      |||.|||.|     :||...||||.||
  Fly   844 QQHQQQVAAQHQQQAAVAAHQQQQQQLQQQQQLLQLSIQQAAHHHQQ-----EQHRQQQQQQHQQ 903

  Fly   788 QQQQHHHPQQQ------PPPQHSMEAHYAQPTAPNGSQSNGHGAELQPHHRMPDPVREDIASTPS 846
            ||||.||.|||      ||||...:                           |.|:.  :.|.||
  Fly   904 QQQQQHHQQQQQGHPQAPPPQQQQQ---------------------------PPPIA--LISDPS 939

  Fly   847 AVGPYDAASITKTTSNSAFTPINSMPPHLNSLSHHP--MAQRPYLY 890
            |:.   .|:|                    .|.|.|  :.|.|.:|
  Fly   940 ALA---RAAI--------------------QLQHLPANVEQHPVVY 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rn	NP_001262343.1	C2H2 Zn finger	490..510	CDD:275368	5/19 (26%)
		C2H2 Zn finger	519..539	CDD:275368	8/19 (42%)
		zf-H2C2_2	531..556	CDD:290200	10/24 (42%)
		zf-C2H2	545..567	CDD:278523	9/21 (43%)
		C2H2 Zn finger	547..567	CDD:275368	8/19 (42%)
		zf-C2H2_8	550..630	CDD:292531	35/127 (28%)
		zf-H2C2_2	559..586	CDD:290200	15/26 (58%)
		C2H2 Zn finger	575..597	CDD:275368	9/50 (18%)
		C2H2 Zn finger	605..625	CDD:275368	7/19 (37%)
		C2H2 Zn finger	636..656	CDD:275368	6/20 (30%)
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	0/19 (0%)
		C2H2 Zn finger	251..271	CDD:275368	4/19 (21%)
		C2H2 Zn finger	279..299	CDD:275368	5/25 (20%)
		COG5048	300..723	CDD:227381	103/488 (21%)
		C2H2 Zn finger	307..327	CDD:275368	1/19 (5%)
		C2H2 Zn finger	335..355	CDD:275368	3/19 (16%)
		C2H2 Zn finger	363..383	CDD:275368	3/19 (16%)
		C2H2 Zn finger	391..411	CDD:275368	4/22 (18%)
		C2H2 Zn finger	419..439	CDD:275368	4/19 (21%)
		C2H2 Zn finger	447..467	CDD:275368	4/21 (19%)
		C2H2 Zn finger	475..495	CDD:275368	3/40 (8%)
		C2H2 Zn finger	503..523	CDD:275368	5/19 (26%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	7/21 (33%)
		C2H2 Zn finger	615..636	CDD:275368	2/20 (10%)
		C2H2 Zn finger	644..664	CDD:275368	7/19 (37%)
		C2H2 Zn finger	676..696	CDD:275368	2/19 (11%)
		C2H2 Zn finger	704..722	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100