Protein Alignment rn and ZNF546

DIOPT Version :10

• Sequence 1: NP_001262343.1
• Gene: rn / 40879
• FlyBaseID: FBgn0267337
• Length: 952
• Species: Drosophila melanogaster
• Sequence 2: NP_848639.2
• Gene: ZNF546 / 339327
• HGNCID: 28671
• Length: 836
• Species: Homo sapiens
• Alignment Length: 187
• Identity: 73/187 - (39%)
• Similarity: 107/187 - (57%)
• Gaps: 21/187 - (11%)

  Fly   486 RKYQCKMCPQIFSSKADLQLHTQIHMREAKPYKCTQCSKAFANSSYLSQHTRIHLGIKPYRCEIC 550
            |.|:||:|.:.|..:..:..|.:|| ...|||||.:|.|||::.|||.||.:||.|.|||.|:.|
Human   355 RPYECKVCGKTFRVQRHISQHQKIH-TGVKPYKCNECGKAFSHGSYLVQHQKIHTGEKPYECKEC 418

  Fly   551 QRKFTQLSHLQQHIRTHTGDKPYKCRHPGCQKAFSQLSNLQSHSRCHQTDKPFKCNSCYKCFSDE 615
            .:.|:..:.|.:|.|.|||:|||:||.  |.|||...:.|..|.|.|..:||::|..|.|.|
Human   419 GKSFSFHAELARHRRIHTGEKPYECRE--CGKAFRLQTELTRHHRTHTGEKPYECKECGKAF--- 478

  Fly   616 PSLLEHIPKHKESKHLKTHI------CQYCGKSYTQETYLTKHMQKHAERTDKRPPI 666
                  |..::.:.||:||.      |:.|||:::...:||:|.:.|   |.::|.|
Human   479 ------ICGYQLTLHLRTHTGEIPYECKECGKTFSSRYHLTQHYRIH---TGEKPYI 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rn	NP_001262343.1	C2H2 Zn finger	490..510	CDD:275368	5/19 (26%)
		C2H2 Zn finger	519..539	CDD:275368	10/19 (53%)
		COG5048	543..>647	CDD:227381	40/109 (37%)
		C2H2 Zn finger	547..567	CDD:275368	6/19 (32%)
		zf-H2C2_2	559..586	CDD:463886	15/26 (58%)
		C2H2 Zn finger	575..597	CDD:275368	9/21 (43%)
		C2H2 Zn finger	605..625	CDD:275368	5/19 (26%)
		C2H2 Zn finger	636..656	CDD:275368	7/19 (37%)
ZNF546	NP_848639.2	KRAB	60..120	CDD:214630
		COG5048	<215..375	CDD:227381	6/19 (32%)
		C2H2 Zn finger	219..239	CDD:275368
		C2H2 Zn finger	247..267	CDD:275368
		C2H2 Zn finger	275..295	CDD:275368
		C2H2 Zn finger	303..323	CDD:275368
		C2H2 Zn finger	331..351	CDD:275368
		C2H2 Zn finger	359..379	CDD:275368	5/19 (26%)
		COG5048	383..823	CDD:227381	64/158 (41%)
		C2H2 Zn finger	387..407	CDD:275368	10/19 (53%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		C2H2 Zn finger	443..463	CDD:275368	9/21 (43%)
		C2H2 Zn finger	471..491	CDD:275368	7/28 (25%)
		C2H2 Zn finger	499..519	CDD:275368	7/19 (37%)
		C2H2 Zn finger	527..547	CDD:275368	73/187 (39%)
		C2H2 Zn finger	555..575	CDD:275368
		C2H2 Zn finger	583..603	CDD:275368
		C2H2 Zn finger	611..631	CDD:275368
		C2H2 Zn finger	639..659	CDD:275368
		C2H2 Zn finger	667..687	CDD:275368
		C2H2 Zn finger	695..715	CDD:275368
		C2H2 Zn finger	723..743	CDD:275368
		C2H2 Zn finger	751..771	CDD:275368
		C2H2 Zn finger	779..799	CDD:275368
		C2H2 Zn finger	807..827	CDD:275368