DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rn and Zfp384

DIOPT Version :9

Sequence 1:	NP_001262343.1	Gene:	rn / 40879	FlyBaseID:	FBgn0267337	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_001359349.1	Gene:	Zfp384 / 269800	MGIID:	2443203	Length:	615	Species:	Mus musculus

Alignment Length:	729	Identity:	213/729 - (29%)
Similarity:	286/729 - (39%)	Gaps:	158/729 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 NNNGYSWS-----TGN----------NNEVVSHSSNGHTNNHPTTPPTPPNEASATQATSVSAIN 210
            |:|.|.|.     :|.          .::::.....|....|..|..|.|...|.:...|:...:
Mouse     7 NSNPYFWPSIPTVSGQIENTMFINKMKDQLLPEKGCGLAPPHYPTLLTVPASVSLSSGISMDTES 71

  Fly   211 LN-QAQPASQTRSNFGSSIKSPPSEPDAVTAATCKSQENNSGQNPTPNSLSDHNPAHNLNSNSTA 274
            .: |..|.||.......::...||........:|..:....|.......|...:|:.:|.:.::|
Mouse    72 KSEQLTPHSQASVTQNITVVPVPSTGLMTAGVSCSQRWRREGSQSRGPGLVITSPSGSLVTTASA 136

  Fly   275 AAVAAAAAAAAAANMPIGGVQGQNPTQGLVHWMSAVMAEHMTGQTHHDPGAVGMHYMWNGNVDHA 339
            |.....:|....:.:|.|. |.......|...:::.:.|...|      |..|     .|.|...
Mouse   137 AQTFPISAPMIVSALPPGS-QALQVVPDLSKKVASTLTEEGGG------GGGG-----GGTVAPP 189

  Fly   340 KDISDYNLWPPTPRSHQHASEHHPMSLKQEYE-AKMNDHHHNNLQKGHFLDDNRLEHHAVTGQGG 403
            |        ||..|..:...|.....:...|. |..:|..|....|.:     |.|.:..|| .|
Mouse   190 K--------PPRGRKKKRMLESGLPEMNDPYVLAPGDDDDHQKDGKTY-----RSEGNCGTG-NG 240

  Fly   404 LGLGASNGVGGGGGGASVVGNSSLGASSHHAVAAAHHHNQAVAAASAAALLVVPQPINASKMGGP 468
            ..||..:.|.|............:.:.:.::.:....|:::....         :|.........
Mouse   241 QSLGLMDSVPGSTTNLLCDPGCRMCSLTFYSKSEMQIHSKSHTET---------KPHKCPHCSKT 296

  Fly   469 GGVSSVAGGHATGGGSGRKYQCKMCPQIFSSKADLQLHTQIHMR----EAKPYKCTQCSKAFANS 529
            ...||....|.......:.|.|..|.:.|...:.||.||:||.:    ..||:||..|||.|||:
Mouse   297 FANSSYLAQHIRIHSGAKPYSCNFCEKSFRQLSHLQQHTRIHSKMHTETIKPHKCPHCSKTFANT 361

  Fly   530 SYLSQHTRIHLGIKPYRCEICQRKFTQLSHLQQHIRTHTGDKPYKCRHPGCQKAFSQLSNLQSHS 594
            |||:||.|||.|.|||.|..||:.|.||||||||.|.||||:||||.||||:|||:||||||||.
Mouse   362 SYLAQHLRIHSGAKPYNCSYCQKAFRQLSHLQQHTRIHTGDRPYKCAHPGCEKAFTQLSNLQSHR 426

  Fly   595 RCHQTDKPFKCNSCYKCFSDEPSLLEHIPKHKESKHLKTHICQYCGKSYTQETYLTKHMQKHAER 659
            |.|..||||||::|::.::|..||..|:..| ..||.|.:.|..|.::||.||||.|||:||
Mouse   427 RQHNKDKPFKCHNCHRAYTDAASLEAHLSTH-TVKHAKVYTCTICSRAYTSETYLMKHMRKH--- 487

  Fly   660 TDKRPPIVPGSAAAIAAAAAAAAGGSANPANGPPPPPNPAQHQRNNLGLPPVSIAPSDNGYWPKV 724
               .||.:.....|.|||||.|
Mouse   488 ---NPPDLQQQVQAAAAAAAVA------------------------------------------- 506

  Fly   725 SPDSAAAANAMEVMHQQQQQQQQQQQQQQQQQQQQQQQAHHHHPQHGVPPQQHVPPQQQQQQQQQ 789
              .:.|.|.|     |.|.|.|.|.|.|.|.|.|.|.||                  |..|..||
Mouse   507 --QAQAQAQA-----QAQAQAQAQAQAQAQAQAQAQAQA------------------QASQASQQ 546

  Fly   790 QQHHHPQQQPPPQHSMEAHYAQP-TAPNGSQSNGHGAELQPHHRMPDPVREDIASTPSAVGPYDA 853
            ||    |||||||   ..|:..| .||.|    |.|.:..|:   |.|      .....:.||..
Mouse   547 QQ----QQQPPPQ---PPHFQSPGAAPQG----GGGGDSNPN---PPP------QCSFDLTPYKP 591

  Fly   854 AS------ITKTTS 861
            |.      :|.|||
Mouse   592 AEHHKDICLTVTTS 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rn	NP_001262343.1	C2H2 Zn finger	490..510	CDD:275368	7/19 (37%)
		C2H2 Zn finger	519..539	CDD:275368	13/19 (68%)
		zf-H2C2_2	531..556	CDD:290200	15/24 (63%)
		zf-C2H2	545..567	CDD:278523	14/21 (67%)
		C2H2 Zn finger	547..567	CDD:275368	13/19 (68%)
		zf-C2H2_8	550..630	CDD:292531	49/79 (62%)
		zf-H2C2_2	559..586	CDD:290200	21/26 (81%)
		C2H2 Zn finger	575..597	CDD:275368	17/21 (81%)
		C2H2 Zn finger	605..625	CDD:275368	6/19 (32%)
		C2H2 Zn finger	636..656	CDD:275368	11/19 (58%)
Zfp384	NP_001359349.1	C2H2 Zn finger	262..282	CDD:275368	1/19 (5%)
		COG5048	<285..440	CDD:227381	80/163 (49%)
		C2H2 Zn finger	290..310	CDD:275368	3/19 (16%)
		C2H2 Zn finger	318..338	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..371	CDD:275368	13/19 (68%)
		C2H2 Zn finger	379..399	CDD:275368	13/19 (68%)
		C2H2 Zn finger	407..429	CDD:275368	17/21 (81%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..487	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43024
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910