DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rn and Vezf1

DIOPT Version :9

Sequence 1:	NP_001262343.1	Gene:	rn / 40879	FlyBaseID:	FBgn0267337	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	XP_036012519.1	Gene:	Vezf1 / 22344	MGIID:	1313291	Length:	556	Species:	Mus musculus

Alignment Length:	344	Identity:	88/344 - (25%)
Similarity:	129/344 - (37%)	Gaps:	99/344 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   437 AAHHHNQAVAAASAAALLVVPQPINASKMGGPGG----VSSVAG--GHATGGGSGRKYQCKMCPQ 495
            :.|...:.|:.|......|||.   .|.:.|...    ||::||  ...|...||..      |.
Mouse   126 SCHTGIKLVSRAKKTPTTVVPL---ISTIAGDSSRTSLVSTIAGILSTVTTSSSGTN------PS 181

  Fly   496 IFSSKADLQLHTQIHMREAKPYK----CTQCSKAFANSSYLSQHTRIHLGIKPYRCEICQRKFTQ 556
            ..:|...:.:...: .:.:||.|    |..|.|||.:..:|::|...|...||:.|.||.::|.:
Mouse   182 SSASTTSMPVPQSV-KKPSKPVKKNHACEMCGKAFRDVYHLNRHKLSHSDEKPFECPICNQRFKR 245

  Fly   557 LSHLQQHIRTHTG--DKPYKCRHPGCQKAFSQLSNLQSH-SRCHQTDKPFKC------NSCYKCF 612
            ...:..|:|:|.|  .|||.|  ..|.|.||:..:|..| ...|.|::||||      .:|...|
Mouse   246 KDRMTYHVRSHEGGITKPYTC--SVCGKGFSRPDHLSCHVKHVHSTERPFKCQFSSLMQTCTAAF 308

  Fly   613 SDEPSLLEHIPKHKESKHLKTHICQYCGKSYTQETYLTKHMQKHAERTDKRPPIVPGSAAAIAAA 677
            :.:..|..|:.:|:....     |..||| .....|:|.|::.|
Mouse   309 ATKDRLRTHMVRHEGKVS-----CNICGK-LLSAAYITSHLKTH--------------------- 346

  Fly   678 AAAAAGGSANPANGPPPPPNPAQHQRNNLGLPPVSIAPSDNGYWPKVSPDSAAAANAMEVMHQQQ 742
                                 .|.|..|.......|:.:                    .|.::.
Mouse   347 ---------------------GQSQSINCNTCKQGISKT--------------------CMSEET 370

  Fly   743 QQQQQQQQQQQQQQQQQQQ 761
            ..|:|||||||||||||||
Mouse   371 SNQKQQQQQQQQQQQQQQQ 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rn	NP_001262343.1	C2H2 Zn finger	490..510	CDD:275368	2/19 (11%)
		C2H2 Zn finger	519..539	CDD:275368	7/19 (37%)
		zf-H2C2_2	531..556	CDD:290200	9/24 (38%)
		zf-C2H2	545..567	CDD:278523	6/21 (29%)
		C2H2 Zn finger	547..567	CDD:275368	6/19 (32%)
		zf-C2H2_8	550..630	CDD:292531	27/88 (31%)
		zf-H2C2_2	559..586	CDD:290200	11/28 (39%)
		C2H2 Zn finger	575..597	CDD:275368	7/22 (32%)
		C2H2 Zn finger	605..625	CDD:275368	5/25 (20%)
		C2H2 Zn finger	636..656	CDD:275368	7/19 (37%)
Vezf1	XP_036012519.1	zf-C2H2	106..125	CDD:395048
		C2H2 Zn finger	108..128	CDD:275368	0/1 (0%)
		zf-C2H2	206..228	CDD:395048	7/21 (33%)
		C2H2 Zn finger	208..228	CDD:275368	7/19 (37%)
		SFP1	<230..287	CDD:227516	20/58 (34%)
		C2H2 Zn finger	236..256	CDD:275368	6/19 (32%)
		C2H2 Zn finger	266..284	CDD:275368	7/19 (37%)
		C2H2 Zn finger	295..321	CDD:275368	5/25 (20%)
		motB	<415..532	CDD:183756
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	159	1.000	Inparanoid score	I4235
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050