DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rn and ZNF367

DIOPT Version :9

Sequence 1:	NP_001262343.1	Gene:	rn / 40879	FlyBaseID:	FBgn0267337	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_710162.1	Gene:	ZNF367 / 195828	HGNCID:	18320	Length:	350	Species:	Homo sapiens

Alignment Length:	342	Identity:	81/342 - (23%)
Similarity:	127/342 - (37%)	Gaps:	101/342 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   438 AHHHNQAVAAASAAALLVVPQPINASKMG--GPGGVSSVAGGHATGGGSGRKYQCKMCPQIFSSK 500
            ||:...:..||.|||...:|....|...|  |.|.....|...|...|...:.:        :|.
Human    77 AHNVTLSPGAAGAAASAALPAAAAAEHSGLRGRGAPPPAASASAAASGGEDEEE--------ASS 133

  Fly   501 ADLQLHTQIHMREAKPYKCTQCSKAFANSSYLSQHTRIHLGIKPYRCEICQRKFTQLSHLQQHIR 565
            .| ..|.:..:|..:|...|  .:...|.   .:|:...:     ||.||.|.|.:...||.|.|
Human   134 PD-SGHLKDGIRRGRPRADT--VRDLINE---GEHSSSRI-----RCNICNRVFPREKSLQAHKR 187

  Fly   566 THTGDKPYKCRHPGCQKAFSQLSNLQSHSRCHQTDKPFKC--NSCYKCFSDEPSLLEHIPKHKES 628
            ||||::||.|.:|.|.|||.|...|::|.|.|..:|||.|  |.|...|:...   .|.|||..:
Human   188 THTGERPYLCDYPDCGKAFVQSGQLKTHQRLHTGEKPFVCSENGCLSRFTHAN---RHCPKHPYA 249

  Fly   629 KHLKTHICQYCGKSYTQETYLTKH-----------MQKHAERTDKRPPIVPGSAAAIAAAAAAAA 682
            : ||        :....:| |:||           :.::.|..::|.|.:.|.....|
Human   250 R-LK--------REEPTDT-LSKHQAADNKAAAEWLARYWEMREQRTPTLKGKLVQKA------- 297

  Fly   683 GGSANPANGPPPPPNPAQHQRNNLGLPPVSIAPSDNGYWPKVSPDSAAAANAMEVMHQQQQQQQQ 747
                            .|.|::     |:....||                          ::..
Human   298 ----------------DQEQQD-----PLEYLQSD--------------------------EEDD 315

  Fly   748 QQQQQQQQQQQQQQQAH 764
            :::..|::.|:|:::.|
Human   316 EKRGAQRRLQEQRERLH 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rn	NP_001262343.1	C2H2 Zn finger	490..510	CDD:275368	3/19 (16%)
		C2H2 Zn finger	519..539	CDD:275368	3/19 (16%)
		zf-H2C2_2	531..556	CDD:290200	7/24 (29%)
		zf-C2H2	545..567	CDD:278523	10/21 (48%)
		C2H2 Zn finger	547..567	CDD:275368	9/19 (47%)
		zf-C2H2_8	550..630	CDD:292531	35/81 (43%)
		zf-H2C2_2	559..586	CDD:290200	16/26 (62%)
		C2H2 Zn finger	575..597	CDD:275368	10/21 (48%)
		C2H2 Zn finger	605..625	CDD:275368	6/21 (29%)
		C2H2 Zn finger	636..656	CDD:275368	4/30 (13%)
ZNF367	NP_710162.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..151		11/55 (20%)
		COG5048	167..>240	CDD:227381	34/77 (44%)
		zf-C2H2	168..189	CDD:278523	10/20 (50%)
		C2H2 Zn finger	169..189	CDD:275368	9/19 (47%)
		zf-H2C2_2	181..208	CDD:290200	16/26 (62%)
		C2H2 Zn finger	197..219	CDD:275368	10/21 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..327		9/90 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870