DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rn and Zfp384

DIOPT Version :9

Sequence 1:	NP_001262343.1	Gene:	rn / 40879	FlyBaseID:	FBgn0267337	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	XP_038962888.1	Gene:	Zfp384 / 171018	RGDID:	708346	Length:	680	Species:	Rattus norvegicus

Alignment Length:	729	Identity:	207/729 - (28%)
Similarity:	281/729 - (38%)	Gaps:	161/729 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 NNNGYSWS-----TGN----------NNEVVSHSSNGHTNNHPTTPPTPPNEASATQATSVSAIN 210
            |:|.|.|.     :|.          .::::.....|....|..|..|.|...|.:...|:...:
  Rat    75 NSNPYFWPSIPTVSGQIENTMFINKMKDQLLPEKGCGLAPPHYPTLLTVPASVSLSSGISMDTES 139

  Fly   211 LN-QAQPASQTRSNFGSSIKSPPSEPDAVTAATCKSQENNSGQNPTPNSLSDHNPAHNLNSNSTA 274
            .: |..|.||.......::...||........:|..:....|.......|...:|:.:|.:.:::
  Rat   140 KSEQLTPHSQASVTQNITVVPVPSTGLMTAGVSCSQRWRREGSQSRGPGLVITSPSGSLVTTASS 204

  Fly   275 AAVAAAAAAAAAANMPIGGVQGQNPTQGLVHWMSAVMAEHMTGQTHHDPGAVGMHYMWNGNVDHA 339
            |.....:.....:.:|.|. |.......|...:::.:.|...|      |..|     .|.|...
  Rat   205 AQTFPISTPMIVSALPPGS-QALQVVPDLSKKVASTLTEEGGG------GGGG-----GGTVAPP 257

  Fly   340 KDISDYNLWPPTPRSHQHASEHHPMSLKQEYE-AKMNDHHHNNLQKGHFLDDNRLEHHAVTGQGG 403
            |        ||..|..:...|.....:...|. |..:|..|....|.:     |.|.:..|| .|
  Rat   258 K--------PPRGRKKKRMLESGLPEMNDPYVLAPGDDDDHQKDGKTY-----RSEGNCGTG-NG 308

  Fly   404 LGLGASNGVGGGGGGASVVGNSSLGASSHHAVAAAHHHNQAVAAASAAALLVVPQPINASKMGGP 468
            ..||..:.|.|............:.:.:.::.:....|:::....         :|.........
  Rat   309 QSLGLMDSVPGSTTNLLCDPGCRMCSLTFYSKSEMQIHSKSHTET---------KPHKCPHCSKT 364

  Fly   469 GGVSSVAGGHATGGGSGRKYQCKMCPQIFSSKADLQLHTQIHMR----EAKPYKCTQCSKAFANS 529
            ...||....|.......:.|.|..|.:.|...:.||.||:||.:    ..||:||..|||.|||:
  Rat   365 FANSSYLAQHIRIHSGAKPYSCNFCEKSFRQLSHLQQHTRIHSKMHTETIKPHKCPHCSKTFANT 429

  Fly   530 SYLSQHTRIHLGIKPYRCEICQRKFTQLSHLQQHIRTHTGDKPYKCRHPGCQKAFSQLSNLQSHS 594
            |||:||.|||.|.|||.|..||:.|.||||||||.|.||||:||||.||||:|||:||||||||.
  Rat   430 SYLAQHLRIHSGAKPYNCSYCQKAFRQLSHLQQHTRIHTGDRPYKCAHPGCEKAFTQLSNLQSHR 494

  Fly   595 RCHQTDKPFKCNSCYKCFSDEPSLLEHIPKHKESKHLKTHICQYCGKSYTQETYLTKHMQKHAER 659
            |.|..||||||::|::.::|..||..|:..| ..||.|.:.|..|.::||.||||.|||:||
  Rat   495 RQHNKDKPFKCHNCHRAYTDAASLEAHLSTH-TVKHAKVYTCTICSRAYTSETYLMKHMRKH--- 555

  Fly   660 TDKRPPIVPGSAAAIAAAAAAAAGGSANPANGPPPPPNPAQHQRNNLGLPPVSIAPSDNGYWPKV 724
               .||.:.....|.|||||.|
  Rat   556 ---NPPDLQQQVQAAAAAAAVA------------------------------------------- 574

  Fly   725 SPDSAAAANAMEVMHQQQQQQQQQQQQQQQQQQQQQQQAHHHHPQHGVPPQQHVPPQQQQQQQQQ 789
                       :...|.|.|.|.|.|.|.|.|.|.|.||                 |..|..|||
  Rat   575 -----------QAQAQAQAQAQAQAQAQAQAQAQAQAQA-----------------QASQASQQQ 611

  Fly   790 QQHHHPQQQPPPQHSMEAHYAQP-TAPNGSQSNGHGAELQPHHRMPDPVREDIASTPSAVGPYDA 853
            ||    ||.||||   ..|:..| .||.|    |.|.:  .:...|.....|:.       ||..
  Rat   612 QQ----QQPPPPQ---PPHFQSPGAAPQG----GGGGD--SNQNPPPQCSFDLT-------PYKP 656

  Fly   854 AS------ITKTTS 861
            |.      :|.|||
  Rat   657 AEHHKDICLTVTTS 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rn	NP_001262343.1	C2H2 Zn finger	490..510	CDD:275368	7/19 (37%)
		C2H2 Zn finger	519..539	CDD:275368	13/19 (68%)
		zf-H2C2_2	531..556	CDD:290200	15/24 (63%)
		zf-C2H2	545..567	CDD:278523	14/21 (67%)
		C2H2 Zn finger	547..567	CDD:275368	13/19 (68%)
		zf-C2H2_8	550..630	CDD:292531	49/79 (62%)
		zf-H2C2_2	559..586	CDD:290200	21/26 (81%)
		C2H2 Zn finger	575..597	CDD:275368	17/21 (81%)
		C2H2 Zn finger	605..625	CDD:275368	6/19 (32%)
		C2H2 Zn finger	636..656	CDD:275368	11/19 (58%)
Zfp384	XP_038962888.1	C2H2 Zn finger	330..350	CDD:275368	1/19 (5%)
		COG5048	<353..508	CDD:227381	80/163 (49%)
		C2H2 Zn finger	358..378	CDD:275368	3/19 (16%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	13/19 (68%)
		C2H2 Zn finger	447..467	CDD:275368	13/19 (68%)
		C2H2 Zn finger	475..497	CDD:275368	17/21 (81%)
		C2H2 Zn finger	505..525	CDD:275368	6/19 (32%)
		C2H2 Zn finger	535..555	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45089
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910