Protein Alignment Syt4 and SYTL5

DIOPT Version :9

• Sequence 1: NP_477464.1
• Gene: Syt4 / 40876
• FlyBaseID: FBgn0028400
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_001156806.1
• Gene: SYTL5 / 94122
• HGNCID: 15589
• Length: 752
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 119/529 - (22%)
• Similarity: 188/529 - (35%)
• Gaps: 166/529 - (31%)

  Fly    59 RRPTAVRSPSGQPPHYLKKSPSPTG-------GKQMGLLSPMQDQSTSPIAQPNVKYSEEGDGPA 116
            |.|.:.|| :|..|. .:.||:|:.       .::.|..:.|...:....:|...|
Human   246 RTPKSSRS-NGVTPG-TQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTK--------- 299

  Fly   117 QHAEQQNGNQLTVVDGNGLKHSLHNS---LHHSPVE------TIANGSVTITLDDHSLTNGKE-- 170
            .|....:|.....|.|..|......|   |..|..|      :|.:.||...||..||...:|
Human   300 SHRRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEETEESI 364

  Fly   171 ---------------------------------LTVTD-------------------QYGKL--- 180
                                             |.|.|                   .||.:
Human   365 DALVSSQLSTNTHRLASGLSTSSQAGSDRKWTYLNVPDADSDTTSLNSMMSVYSETGDYGNVKVS 429

  Fly   181 GTIYFKLRYLAERNALMVSIIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDK--Q 243
            |.|...:.|..:...|.:.:..||.|       ..||       ..:..||.|||..|||||  .
Human   430 GEILLHISYCYKTGGLYIFVKNCRNL-------AIGD-------EKKQRTDAYVKSYLLPDKSRN 480

  Fly   244 HKVKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGD 308
            :|.||: :|...||.::|... |.::...|:..:|...:..:||:.|:..:|||..|..|....:
Human   481 NKRKTK-IRTGTNPEFNETLK-YTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFEN 543

  Fly   309 ISKE--ALSISKEIQPRSLKIRAQGRGELLISLCWQP---------------------------- 343
            .:.|  .|....|..|   .|..|.:|||.:.|.:.|
Human   544 PTDEWFVLQPKVEFAP---DIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPV 605

  Fly   344 -AAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAFDIP 407
             :.|.|.|.:.:|:||..:...|.:|.:||.|||.:..:..|.||.|.|::::|.:|.:|.|
Human   606 ISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMF--- 667

  Fly   408 AAEGAG---ASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNH--------------- 454
                :|   ..::.|.|||.:.|.:..:.|..:|.:.|    :|.:.::|
Human   668 ----SGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRL----NSGSGVSHGKNVDWMDSQGEEQR 724

  Fly   455 -WNEVCNSP 462
             |.::.|:|
Human   725 LWQKMANNP 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	40/149 (27%)
		C2B_Synaptotagmin-4	332..473	CDD:176049	41/179 (23%)
SYTL5	NP_001156806.1	PHD_SF	11..123	CDD:328929
		FYVE_Slp5	62..108	CDD:277305
		CEP170_C	<159..>309	CDD:317681	15/73 (21%)
		C2A_SLP-4_5	429..552	CDD:175995	38/138 (28%)
		C2B_SLP_1-2-3-4	566..744	CDD:175987	41/179 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810