Protein Alignment Syt4 and SYT8

DIOPT Version :9

• Sequence 1: NP_477464.1
• Gene: Syt4 / 40876
• FlyBaseID: FBgn0028400
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: XP_011518757.1
• Gene: SYT8 / 90019
• HGNCID: 19264
• Length: 539
• Species: Homo sapiens
• Alignment Length: 486
• Identity: 121/486 - (24%)
• Similarity: 187/486 - (38%)
• Gaps: 165/486 - (33%)

  Fly     6 IPDASVMDTIVP---AILGLTAAAV-----LSSVACICARQMRLRNKKQSQHDASFPFQPTRRPT 62
            |||. |..|..|   .|.|..||.|     |...||.|.|:.|
Human   175 IPDL-VAGTPWPRWALIAGALAAGVLLVSCLLCAACCCCRRHR---------------------- 216

  Fly    63 AVRSPSGQPPHYLKKSPSPTGGKQMGLLSPMQDQSTSPIAQPNVKYSEEGDGPAQHAEQQNGNQL 127
                         ||   |...:.:||.| .:..:|:.:.||:|...|...|.||
Human   217 -------------KK---PRDKESVGLGS-ARGTTTTHLVQPDVDGLESSPGDAQ---------- 254

  Fly   128 TVVDGNGLKHSLHNSLHHSPVETIANGSVTITLDDHSLTNGKELTVTDQYGKLGTIYFKLRYLAE 192
                                                               :.|.:...|.:
Human   255 ---------------------------------------------------QWGCLQLSLEF--- 265

  Fly   193 RNALMVSIIRCRGLPCKGGSSGTGDIPTGMNGRTQAA-------TDPYVKLQLLPDKQHKVKTRV 250
                               ..|:.:|..|:.   |||       .|||.::.:.....|:.:|:|
Human   266 -------------------DFGSQEIRVGLR---QAADLRPGGTVDPYARVSVSTQAGHRHETKV 308

  Fly   251 VRNTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKE--A 313
            .|.|..||:||...|: :...:|...:|...:.:|.|:|..:.:||:..||.::::..:.:.  .
Human   309 HRGTLCPVFDETCCFH-IPQAELPGATLQVQLFNFKRFSGHEPLGELRLPLGTVDLQHVLEHWYL 372

  Fly   314 LSISKEIQPRSLKIRAQGRGELLISLCWQPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYN 378
            |......||..:       |||..||.:.|::||||||:|:||.|.    .|||:||||:.|:.|
Human   373 LGPPAATQPEQV-------GELCFSLRYVPSSGRLTVVVLEARGLR----PGLAEPYVKVQLMLN 426

  Fly   379 GQRIAKKKTHVKKRTLSPVFNESFAFDIPAAEGAGASLEGVSLELMLLDWDR--VTKNEVIGRLE 441
            .::..|:||..||.|.:|.|||:|.|.:|.::..       :::|:|..|||  ..:.|.:|::.
Human   427 QRKWKKRKTATKKGTAAPYFNEAFTFLVPFSQVQ-------NVDLVLAVWDRSLPLRTEPVGKVH 484

  Fly   442 LGGPNSSSTALNHWNEVCNSPRRQIAEWHKL 472
            ||. .:|...|.||.::....||.||:.|.|
Human   485 LGA-RASGQPLQHWADMLAHARRPIAQRHPL 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	31/151 (21%)
		C2B_Synaptotagmin-4	332..473	CDD:176049	57/143 (40%)
SYT8	XP_011518757.1	C2	257..370	CDD:301316	30/138 (22%)
		C2	385..514	CDD:301316	56/140 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820