DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Syt4 and Doc2b

DIOPT Version :9

Sequence 1:NP_477464.1 Gene:Syt4 / 40876 FlyBaseID:FBgn0028400 Length:474 Species:Drosophila melanogaster
Sequence 2:NP_112404.1 Gene:Doc2b / 81820 RGDID:620519 Length:412 Species:Rattus norvegicus


Alignment Length:455 Identity:132/455 - (29%)
Similarity:196/455 - (43%) Gaps:105/455 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 KKQSQHDASFP--FQPTRRPTAVRSPSGQPPHYLKKSPSPTGGKQMGLLSPMQ---------DQ- 96
            |:.|.:...||  ..||..|.|     ..||....:||:.|.|.:    ||..         || 
  Rat    31 KQISDYFPRFPRGLPPTAAPRA-----SAPPDAPARSPAATAGPR----SPSDGARDDDEDVDQL 86

  Fly    97 ----STSPIAQPNVKYSEEGDGPAQHAEQQNGNQLTVVDGNGLKHSLHNSLHHSPVETIANGSVT 157
                ..||...|         ||                              |||...|...  
  Rat    87 FGAYGASPGPSP---------GP------------------------------SPVRPPAKPP-- 110

  Fly   158 ITLDDHSLTNGKELTVTDQYGKLGTIYFKLRYLAERNALMVSIIRCRGLPCKGGSSGTGDIPTGM 222
               :|....:|.|   :|....|||:.|.|.|..|.|||..:|.:.:||.           |...
  Rat   111 ---EDEPDADGYE---SDDCTALGTLDFSLLYDQENNALHCTISKAKGLK-----------PMDH 158

  Fly   223 NGRTQAATDPYVKLQLLP--DKQHKVKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSF 285
            ||    ..||||||.|||  .|.:|::|:.:|||.||.::|..|:||:...|:...:|...:...
  Rat   159 NG----LADPYVKLHLLPGASKANKLRTKTLRNTLNPSWNETLTYYGITDEDMIRKTLRISVCDE 219

  Fly   286 DRYSRDDVIGEVVCPLTSIEIGDISKEALSISKEI-----QPRSLKIRAQGRGELLISLCWQPAA 345
            |::..::.|||...||..::.......::.:.|::     :.:||    :.||.:||||.:....
  Rat   220 DKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKAEDKSL----EERGRILISLKYSSQK 280

  Fly   346 GRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAFDIPAAE 410
            ..|.|.:::..:|..||..|.:|||||.||..:..:.:|.||.|||:||:|.|||.|.::|...:
  Rat   281 QGLLVGIVRCAHLAAMDANGYSDPYVKTYLKPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGD 345

  Fly   411 GAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNHWNEVCNSPRRQIAEWHKL-NE 474
                 |...:||:.:.|:|....|:.||.:.| |.|:....|.||.:...:..::|..||.| ||
  Rat   346 -----LAKKTLEVTVWDYDIGKSNDFIGGVVL-GINAKGERLKHWFDCLKNKDKRIERWHTLTNE 404

  Fly   475  474
              Rat   405  404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Syt4NP_477464.1 C2A_Synaptotagmin-4-11 179..322 CDD:176034 46/149 (31%)
C2B_Synaptotagmin-4 332..473 CDD:176049 51/141 (36%)
Doc2bNP_112404.1 Mediates interaction with DYNLT1. /evidence=ECO:0000250 1..90 18/67 (27%)
Negatively regulates targeting to plasma membrane. /evidence=ECO:0000250 1..36 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 38..123 28/140 (20%)
C2A_Rabphilin_Doc2 127..250 CDD:176000 45/137 (33%)
Mediates interaction with STXBP3. /evidence=ECO:0000250 257..375 45/127 (35%)
C2B_Rabphilin_Doc2 269..401 CDD:176030 48/137 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000025
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X61
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.910

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