DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt4 and Syt13

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_110466.2	Gene:	Syt13 / 80977	RGDID:	621877	Length:	426	Species:	Rattus norvegicus

Alignment Length:	511	Identity:	130/511 - (25%)
Similarity:	205/511 - (40%)	Gaps:	143/511 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VPAI-LGL---TAAAVLS--SVACICARQMRLRNKKQSQHDASFPFQPTRRPTAVRSPSGQPPHY 74
            ||.| ||.   ||.::|:  .|.|:| |.|                    .|.....|..:.|..
  Rat     5 VPVIALGATLGTATSILALCGVTCLC-RHM--------------------HPKKGLLPRDREPDP 48

  Fly    75 LKKSPSPTGGKQMGLLSPMQD----QSTSPI-AQPNVKY-------------------------S 109
            .|..|        |:|...|.    :||.|: .:|.:|:                         :
  Rat    49 EKARP--------GVLQAAQQFNVKKSTEPVQPRPLLKFPDIYGPRPAVTAPEVINYADYTLGTT 105

  Fly   110 EEGDGPAQHAEQQNGNQLTVVDGNGLKHSLHNSLHHSPVETIANGSVTITLDDHSLT---NGKEL 171
            ||...||....|.:..         ||..:...|...|    .||.|    :|..:.   |.::.
  Rat   106 EESAAPASPQAQSDSR---------LKRQVTEELFILP----QNGVV----EDVCVMETWNPEKA 153

  Fly   172 TVTDQYGKLGTIYFKLRYLAERNALMVSIIRCRGLPCKGGS----SGTGDIPTGMNGRTQAATDP 232
            ...:|..||   :|:|.|..::..|.|:.:.......:||.    .|:..:.||.
  Rat   154 ASWNQAPKL---HFRLDYDQKKAELFVTSLEAVTSDHEGGCDCYIQGSVAVKTGS---------- 205

  Fly   233 YVKLQLLPDKQHKVKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEV 297
                   .:.|..:|.|.:..|    ::|..|. .|...:|...:|...:.:.||:||..||||:
  Rat   206 -------VEAQTALKKRQLHTT----WEEGLTL-PLGEEELPTATLTLTLRTCDRFSRHSVIGEL 258

  Fly   298 -------VCPLTSIEIGDISKEALSISKEIQPRSLKIRAQGRGELLISLCWQPAAGRLTVVLLKA 355
                   ..||.:.:.|::...|            |..:.|.||:|:|:.:.|||.||.|||:||
  Rat   259 RLGLNGASVPLGTAQWGELKTTA------------KEPSAGTGEVLLSISYLPAANRLLVVLIKA 311

  Fly   356 RNL---PRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAFDIPAAEGAGASLE 417
            :||   ...::.| .|..||:.|.:..|::.||:|...|..::||:||...|::|     ...|:
  Rat   312 KNLHSNQSKELLG-KDVSVKVTLKHQAQKLKKKQTKRAKHKINPVWNEMIMFELP-----DDLLQ 370

  Fly   418 GVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNHWNEVCNSPRRQIAEWHKLN 473
            ..|:||.:|.......:..:||..| |.::|.:..:||.|:..:||||||.||:|:
  Rat   371 ASSVELEVLGQGEEGPSCELGRCSL-GLHASGSERSHWEEMLKNPRRQIAMWHQLH 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	33/153 (22%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	53/143 (37%)
Syt13	NP_110466.2	C2	160..277	CDD:301316	32/141 (23%)
Syt13	NP_110466.2	C2B_Synaptotagmin-13	288..425	CDD:176052	53/143 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10024
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920