DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt4 and Syt13

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_109650.1	Gene:	Syt13 / 80976	MGIID:	1933945	Length:	426	Species:	Mus musculus

Alignment Length:	502	Identity:	130/502 - (25%)
Similarity:	207/502 - (41%)	Gaps:	125/502 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VPAI-LGL---TAAAVLS--SVACICARQMR-----LRNKKQSQHDASFP--FQPTRRPTAVRSP 67
            ||.| ||.   ||.::|:  .|.|:| |.|.     |...::...:.:.|  .|..::....:|.
Mouse     5 VPVIALGATLGTATSILALCGVTCLC-RHMHPKKGLLPRDREPDPEKARPGVLQAAQQFNIKKST 68

  Fly    68 SGQPPHYLKKSPSPTGGKQMGLLSPMQDQSTSP----IAQPNVKYSEEGDGPAQHAEQQNGNQLT 128
            ....|..|.|.|...|.:         ...|:|    .|...::.:||...||....|.:..
Mouse    69 EPVQPRPLLKFPDIYGPR---------PAVTAPEVINYADYTLETTEESAAPASPQAQSDSR--- 121

  Fly   129 VVDGNGLKHSLHNSLHHSPVETIANGSVTITLDDHSLT---NGKELTVTDQYGKLGTIYFKLRYL 190
                  ||..:...|...|    .||.|    :|..:.   |.::....:|..||   :|:|.|.
Mouse   122 ------LKRQVTEELSIRP----QNGVV----EDVCVMETWNPEKAASWNQAPKL---HFRLDYD 169

  Fly   191 AERNALMVSIIRCRGLPCKGGS----SGTGDIPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVV 251
            .::..|.|:.:.......:||.    .|:..:.||.                 .:.|..:|.|.:
Mouse   170 QKKAELFVTSLEAVTSDHEGGCDCYIQGSVAVKTGS-----------------VEAQTALKKRQL 217

  Fly   252 RNTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEV-------VCPLTSIEIGDI 309
            ..|    ::|.... .|...:|...:|...:.:.||:||..||||:       ..||.:.:.|::
Mouse   218 HTT----WEEGLAL-PLGEEELPTATLTLTLRTCDRFSRHSVIGELRLGLDGASVPLGAAQWGEL 277

  Fly   310 SKEALSISKEIQPRSLKIRAQGRGELLISLCWQPAAGRLTVVLLKARNL---PRMDVTGLADPYV 371
            ...|            |..:.|.||:|:|:.:.|||.||.|||:||:||   ...::.| .|..|
Mouse   278 KTTA------------KEPSAGAGEVLLSISYLPAANRLLVVLIKAKNLHSNQSKELLG-KDVSV 329

  Fly   372 KIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEV 436
            |:.|.:..|::.||:|...|..::||:||...|::|     ...|...|:||           ||
Mouse   330 KVTLKHQAQKLKKKQTKRAKHKINPVWNEMIMFELP-----DDLLRASSVEL-----------EV 378

  Fly   437 IGR------LELG----GPNSSSTALNHWNEVCNSPRRQIAEWHKLN 473
            :|:      .|||    |.::|.:..:||.|:..:||||||.||:|:
Mouse   379 LGQGEEGPSCELGHCSLGLHASGSERSHWEEMLKNPRRQIAMWHQLH 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	32/153 (21%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	55/153 (36%)
Syt13	NP_109650.1	C2	160..277	CDD:301316	31/141 (22%)
Syt13	NP_109650.1	C2B_Synaptotagmin-13	288..425	CDD:176052	55/153 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920