DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt4 and Pla2g4d

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001019308.1	Gene:	Pla2g4d / 78390	MGIID:	1925640	Length:	825	Species:	Mus musculus

Alignment Length:	268	Identity:	68/268 - (25%)
Similarity:	108/268 - (40%)	Gaps:	66/268 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 LMVSIIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVVRNTRNPVYD 260
            |.|.|:..|.||       ..|:      .:||  ||||.:||......|.||:.|.|:.:||::
Mouse    33 LTVKILEARSLP-------RADL------LSQA--DPYVTVQLPTASGMKFKTQTVTNSSHPVWN 82

  Fly   261 EDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKEALSISKEIQPRSL 325
            |.|:|  |..:.::|: |...|...|..::||:..:|...::.|..|.:.::..|::.: .|..|
Mouse    83 ETFSF--LIQSQVKNI-LELTIYDEDVITKDDICFKVSYDVSEILPGQLLQKTFSLNPQ-GPEEL 143

  Fly   326 KIRAQGRGELLISLCWQPAAGRLTVVLLKARNLPRMDV-------TGLADPYVKIYLLYNGQRIA 383
            .:      |||:...|.|....:|..:|.||.|..:||       |.:|....|:.|     .:.
Mouse   144 DV------ELLMERTWDPPENLITNNVLVARELSHLDVSLDRAGNTAMAAGQDKLEL-----ELM 197

  Fly   384 KKKTHVKKRTLSPVFNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSS 448
            .|.::...:|..|  :.:|.|......|....|.|.                      |.||.:|
Mouse   198 LKGSYEDTQTFFP--DTAFTFSFHYMRGQDTELNGY----------------------LRGPRNS 238

  Fly   449 STALNHWN 456
            .     ||
Mouse   239 G-----WN 241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	36/125 (29%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	30/132 (23%)
Pla2g4d	NP_001019308.1	C2_cPLA2	32..151	CDD:176001	41/142 (29%)
		Patatin_and_cPLA2	278..814	CDD:299702
		PLAc	283..758	CDD:214474
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q86XP0	339..340
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900