Protein Alignment Syt4 and SYT5

DIOPT Version :10

• Sequence 1: NP_477464.1
• Gene: Syt4 / 40876
• FlyBaseID: FBgn0028400
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_003171.2
• Gene: SYT5 / 6861
• HGNCID: 11513
• Length: 386
• Species: Homo sapiens
• Alignment Length: 477
• Identity: 142/477 - (29%)
• Similarity: 219/477 - (45%)
• Gaps: 130/477 - (27%)

  Fly     7 PDAS------VMDTIVPAILGLTAAAVLSSVACICARQMRLRNKKQSQHDASFPFQPTRRPTAVR 65
            ||:|      |....:..|:.::...:.|...|:..:..|.|..|:||..|....|..:
Human    17 PDSSRISHGPVPPWALATIVLVSGLLIFSCCFCLYRKSCRRRTGKKSQAQAQVHLQEVK------ 75

  Fly    66 SPSGQPPHYLKKSPSPTGGKQMGLLSPMQDQSTSPIAQPNVKYSEEG-DGPAQHAEQQNGNQLTV 129
               |....|:.|                        .||.|:..|.. .||.|.          |
Human    76 ---GLGQSYIDK------------------------VQPEVEELEPAPSGPGQQ----------V 103

  Fly   130 VDGNGLKHSLHNSLHHSPVETIANGSVTITLDDHSLTNGKELTVTDQYGKLGTIYFKLRYLAERN 194
            .|    ||                                         :||.:.:.|.|..:..
Human   104 AD----KH-----------------------------------------ELGRLQYSLDYDFQSG 123

  Fly   195 ALMVSIIRCRGLPC--KGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVVRNTRNP 257
            .|:|.|::..||..  .||||                 ||||::.|||||:.:.:|:|.|.|.||
Human   124 QLLVGILQAMGLAALDLGGSS-----------------DPYVRVYLLPDKRRRYETKVHRQTLNP 171

  Fly   258 VYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKEALSISKEIQ- 321
            .:.|.|.| .:...:|....|...:..|||:||:|.||||..|::|:::|    ..:...:|:|
Human   172 HFGETFAF-KVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLG----RPVQAWRELQA 231

  Fly   322 -PRSLKIRAQGRGELLISLCWQPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKK 385
             ||.   ..:..|::..||.:.|.||:|||::|:|:||.:|||.||:|||||::||..|:::.||
Human   232 APRE---EQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKK 293

  Fly   386 KTHVKKRTLSPVFNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSST 450
            ||.:||.||:|.:||:|:|::|..:     ::.|.:||.:||:|::.|||.|||:.:|.. :...
Human   294 KTTIKKNTLNPYYNEAFSFEVPCDQ-----VQKVQVELTVLDYDKLGKNEAIGRVAVGAA-AGGA 352

  Fly   451 ALNHWNEVCNSPRRQIAEWHKL 472
            .|.||.::..:|||.||:||.|
Human   353 GLRHWADMLANPRRPIAQWHSL 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	48/146 (33%)
		C2B_Synaptotagmin-4	332..473	CDD:176049	64/141 (45%)
SYT5	NP_003171.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		3/5 (60%)
		Syt1_2_N	<21..76	CDD:409247	11/63 (17%)
		C2A_Synaptotagmin-1-5-6-9-10	109..231	CDD:176031	47/143 (33%)
		C2	240..374	CDD:472691	63/139 (45%)