Protein Alignment Syt4 and SYT4

DIOPT Version :9

• Sequence 1: NP_477464.1
• Gene: Syt4 / 40876
• FlyBaseID: FBgn0028400
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_065834.1
• Gene: SYT4 / 6860
• HGNCID: 11512
• Length: 425
• Species: Homo sapiens
• Alignment Length: 468
• Identity: 179/468 - (38%)
• Similarity: 261/468 - (55%)
• Gaps: 70/468 - (14%)

  Fly    16 VPAILGLTAA----AVLSSVACICARQMRLRNKKQSQHDASFPFQPTRRPTAVRSPSGQPPHYLK 76
            :|.::|:.:|    ..:|..|.||.:      :|.|:.:.:.|::..              |.||
Human    14 IPTVVGIFSAFGLVFTVSLFAWICCQ------RKSSKSNKTPPYKFV--------------HVLK 58

  Fly    77 K---SPSPTGGKQMGLLSPMQDQSTSPIAQPNVKYSEEGDGPAQHAEQQ----NGNQLTVVDGNG 134
            .   .|.....|:........:....|....|          :.|.:.:    |||    .....
Human    59 GVDIYPENLNSKKKFGADDKNEVKNKPAVPKN----------SLHLDLEKRDLNGN----FPKTN 109

  Fly   135 LKHSLHNSLHHSPVETIANGSVTITLDDHSLTNGKELTVTDQYGKLGTIYFKLRYLAERNALMVS 199
            ||....:.|.::..:....|... ::...||.:...||..::..||||::|.|.|..||.|.:|:
Human   110 LKPGSPSDLENATPKLFLEGEKE-SVSPESLKSSTSLTSEEKQEKLGTLFFSLEYNFERKAFVVN 173

  Fly   200 IIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVVRNTRNPVYDEDFT 264
            |...||||.....|.|              :|||:|:.:||:|:|||||||:|.|.:|.:||.||
Human   174 IKEARGLPAMDEQSMT--------------SDPYIKMTILPEKKHKVKTRVLRKTLDPAFDETFT 224

  Fly   265 FYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKEALSISKEIQPRSLKIRA 329
            |||:....:|.::|||.||||||:||||:||||:.||:.||   :|:..:.:::||..|::: ::
Human   225 FYGIPYTQIQELALHFTILSFDRFSRDDIIGEVLIPLSGIE---LSEGKMLMNREIIKRNVR-KS 285

  Fly   330 QGRGELLISLCWQPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTL 394
            .||||||||||:|.....||||:||||:||:.||:||:|||||:.|.:..:||:||||||||.|.
Human   286 SGRGELLISLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKTHVKKCTP 350

  Fly   395 SPVFNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNHWNEVC 459
            :.||||.|.|||| .||    ||.:|:|.::||.:|.::|||||:|.||.. :..|...||.|:|
Human   351 NAVFNELFVFDIP-CEG----LEDISVEFLVLDSERGSRNEVIGQLVLGAA-AEGTGGEHWKEIC 409

  Fly   460 NSPRRQIAEWHKL 472
            :.||||||:||.|
Human   410 DYPRRQIAKWHVL 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	67/142 (47%)
		C2B_Synaptotagmin-4	332..473	CDD:176049	81/141 (57%)
SYT4	NP_065834.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	73..93		2/29 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	127..147		4/20 (20%)
		C2A_Synaptotagmin-4-11	153..279	CDD:176034	67/142 (47%)
		C2B_Synaptotagmin-4	288..423	CDD:176049	81/141 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5601
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2845
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D329810at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		otm40578
orthoMCL	1	0.900	-	-		OOG6_106708
Panther	1	1.100	-	-	O	PTHR10024
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9815
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.900