Protein Alignment Syt4 and SYT1

DIOPT Version :9

• Sequence 1: NP_477464.1
• Gene: Syt4 / 40876
• FlyBaseID: FBgn0028400
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_001129277.1
• Gene: SYT1 / 6857
• HGNCID: 11509
• Length: 422
• Species: Homo sapiens
• Alignment Length: 473
• Identity: 146/473 - (30%)
• Similarity: 230/473 - (48%)
• Gaps: 129/473 - (27%)

  Fly     7 PDASVMDTIVPAILGLTAAAVLSSVACICARQM-RLRNKKQSQHDASFPFQPTRRPTAVRSPSGQ 70
            |.|.:...||..:|      ||:...|||.:.: :.:|||:.:.
Human    58 PWALIAIAIVAVLL------VLTCCFCICKKCLFKKKNKKKGKE--------------------- 95

  Fly    71 PPHYLKKSPSPTGGKQMGLLSPMQDQSTSPIAQPNVKYSEEGDGPAQHAEQQNGNQLTVVDGNGL 135
                       .|||                                       |.:.:.|...|
Human    96 -----------KGGK---------------------------------------NAINMKDVKDL 110

  Fly   136 KHSLHN-SLHHSPVETIANGSVTITLDDHSLTNGKELTVTDQYGKLGTIYFKLRYLAERNALMVS 199
            ..::.: :|.....||             .||:|:|.....:..|||.:.:.|.|..:.|.|:|.
Human   111 GKTMKDQALKDDDAET-------------GLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVG 162

  Fly   200 IIRCRGLPC--KGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVVRNTRNPVYDED 262
            ||:...||.  .||:|                 |||||:.|||||:.|.:|:|.|.|.|||::|.
Human   163 IIQAAELPALDMGGTS-----------------DPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQ 210

  Fly   263 FTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKE---ALSISKEIQPRS 324
            ||| .:..::|...:|...:..|||:|:.|:|||...|:.:::.|.:::|   ..|..||.|.:
Human   211 FTF-KVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEK- 273

  Fly   325 LKIRAQGRGELLISLCWQPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHV 389
                   .|::..||.:.|.||:||||:|:|:||.:|||.||:||||||:|:.||:|:.||||.:
Human   274 -------LGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTI 331

  Fly   390 KKRTLSPVFNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNH 454
            ||.||:|.:||||:|::|..:     ::.|.:.:.:||:|::.||:.||::.: |.||:...|.|
Human   332 KKNTLNPYYNESFSFEVPFEQ-----IQKVQVVVTVLDYDKIGKNDAIGKVFV-GYNSTGAELRH 390

  Fly   455 WNEVCNSPRRQIAEWHKL 472
            |:::..:|||.||:||.|
Human   391 WSDMLANPRRPIAQWHTL 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	53/147 (36%)
		C2B_Synaptotagmin-4	332..473	CDD:176049	66/141 (47%)
SYT1	NP_001129277.1	Syt1_N	6..113	CDD:409248	19/131 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..142		7/41 (17%)
		Phospholipid binding. /evidence=ECO:0000305	136..382		107/277 (39%)
		C2A_Synaptotagmin-1-5-6-9-10	143..265	CDD:176031	49/139 (35%)
		C2B_Synaptotagmin-1	274..409	CDD:176047	66/141 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820