DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt4 and Doc2a

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_075226.1	Gene:	Doc2a / 65031	RGDID:	620518	Length:	403	Species:	Rattus norvegicus

Alignment Length:	402	Identity:	117/402 - (29%)
Similarity:	182/402 - (45%)	Gaps:	69/402 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 PIAQPNVKYSEEGDGPAQHAEQQNGNQLTVVDGNGLKHSLHNSLHHSPVETIANGSV--TITLDD 162
            ||.|.:..:...|.||      :.|.     .|.|...:   ..|.:|:......::  ..|.||
  Rat    28 PIRQISDYFPRRGPGP------EGGG-----GGRGFGEA---PAHLAPLALAPPAALLGATTPDD 78

  Fly   163 HSLTNGKELTVTDQYGKLGTIYFKLRYLAERNALMVSIIRCRGLPCKGGSSGTGDIPTGMNGRTQ 227
            .:..:..:   :|....|||:.|.|.|......|...|:|.:||.           |...||
  Rat    79 GAEVDSYD---SDDTTALGTLEFDLLYDQASCMLHCRILRAKGLK-----------PMDFNG--- 126

  Fly   228 AATDPYVKLQLLPD--KQHKVKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSR 290
             ..||||||.|||.  |.:|:||:..|||.|||::|:.|:.|:..:|:.:..|...:...|:.|.
  Rat   127 -LADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEELTYSGITDDDITHKVLRISVCDEDKLSH 190

  Fly   291 DDVIGEVVCPLTSIEIGDISKEALSISKEIQ-----PRSLKIRAQG------------------- 331
            ::.|||:..||..::  ...|:..:|..|.|     |.|:....:|
  Rat   191 NEFIGEIRVPLRRLK--PSQKKHFNICLERQVPLPSPSSMSAALRGISCYLKELEQAEQGPGLLE 253

  Fly   332 -RGELLISLCWQPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLS 395
             ||.:|:||.:......|.|.:::..:|..|||.|.:|||||.||..:..:.:|.||.|||:||:
  Rat   254 ERGRILLSLSYSSRRHGLLVGIVRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLN 318

  Fly   396 PVFNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNHWNEVCN 460
            |.|||.|.:::..     ::|...:||:.:.|:|....|:.||.:.| ||.:...|..||.:..:
  Rat   319 PEFNEEFFYEMEL-----STLATKTLEVTVWDYDIGKSNDFIGGVSL-GPGARGEAQKHWRDCLH 377

  Fly   461 SPRRQIAEWHKL 472
            .|...:..||.|
  Rat   378 QPDTAVERWHTL 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	49/149 (33%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	50/141 (35%)
Doc2a	NP_075226.1	Interaction with UNC13D and DYNLT1. /evidence=ECO:0000250	1..92		15/80 (19%)
		C2A_Rabphilin_Doc2	93..216	CDD:176000	47/139 (34%)
		Interaction with UNC13D. /evidence=ECO:0000250	218..403		54/178 (30%)
		C2B_Rabphilin_Doc2	257..389	CDD:176030	47/137 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910