DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt4 and Syt4

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_113881.1	Gene:	Syt4 / 64440	RGDID:	68397	Length:	425	Species:	Rattus norvegicus

Alignment Length:	478	Identity:	181/478 - (37%)
Similarity:	254/478 - (53%)	Gaps:	90/478 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VPAILGLTAA----AVLSSVACICARQMRLRNKKQSQHDASFPFQPTRRPTAVRSPSGQPP---- 72
            :|.::|:.:|    ..:|..|.||.::...::.|                        .||
  Rat    14 IPTVVGIFSAFGLVFTVSLFAWICCQRRSAKSNK------------------------TPPYKFV 54

  Fly    73 HYLK---------KSPSPTGGKQMGLLSPMQDQSTSPIAQPNVKYSEEGDGPAQHAEQQ----NG 124
            |.||         .|....||..       :.::....|.||:         :.|.:.:    ||
  Rat    55 HVLKGVDIYPENLSSKKKFGGDD-------KSEAKRKAALPNL---------SLHLDLEKRDLNG 103

  Fly   125 NQLTVVDGNGLKHSLHNSLHHSPVETIANGSVTITLDDHSLTNGKELTVTDQYGKLGTIYFKLRY 189
            |........|....|.|.......||...     .:...||.:...||..::..||||::..|.|
  Rat   104 NFPKTNPKAGSSSDLENVTPKLFPETEKE-----AVSPESLKSSTSLTSEEKQEKLGTLFLSLEY 163

  Fly   190 LAERNALMVSIIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVVRNT 254
            ..|:.|.:|:|...:|||.....|.|              :|||:|:.:||:|:|||||||:|.|
  Rat   164 NFEKKAFVVNIKEAQGLPAMDEQSMT--------------SDPYIKMTILPEKKHKVKTRVLRKT 214

  Fly   255 RNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKEALSISKE 319
            .:||:||.|||||:....:|.:||||.:|||||:|||||||||:.||:.||:.|   ..:.:::|
  Rat   215 LDPVFDETFTFYGVPYPHIQELSLHFTVLSFDRFSRDDVIGEVLVPLSGIELSD---GKMLMTRE 276

  Fly   320 IQPRSLKIRAQGRGELLISLCWQPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAK 384
            |..|:.| ::.||||||:|||:|.....||||:||||:||:.||:||:|||||:.|.:..:||:|
  Rat   277 IIKRNAK-KSSGRGELLVSLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISK 340

  Fly   385 KKTHVKKRTLSPVFNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSS 449
            |||||||.|.:.||||.|.||||.     .|||.:|:|.::||.:|.::|||||||.||.....|
  Rat   341 KKTHVKKCTPNAVFNELFVFDIPC-----ESLEEISVEFLVLDSERGSRNEVIGRLVLGATAEGS 400

  Fly   450 TALNHWNEVCNSPRRQIAEWHKL 472
            .. .||.|:|:.||||||:||.|
  Rat   401 GG-GHWKEICDFPRRQIAKWHML 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	66/142 (46%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	80/141 (57%)
Syt4	NP_113881.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..121		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..147		3/20 (15%)
		C2A_Synaptotagmin-4-11	153..279	CDD:176034	48/125 (38%)
		C2B_Synaptotagmin-4	288..423	CDD:176049	72/134 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5458
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	285	1.000	Inparanoid score	I2771
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D329810at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		otm44716
orthoMCL	1	0.900	-	-		OOG6_106708
Panther	1	1.100	-	-	O	PTHR10024
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870