DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt4 and Syt9

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_068689.2	Gene:	Syt9 / 60510	MGIID:	1926373	Length:	491	Species:	Mus musculus

Alignment Length:	505	Identity:	167/505 - (33%)
Similarity:	247/505 - (48%)	Gaps:	100/505 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PDASV-MDTIVPAILGLTAAAVLSSVAC-ICARQMRLR-----NKKQSQHDASFPFQPTRRPTAV 64
            ||.|| :.|:|....||....|...|:. :|....|.|     :|..:|.    |...|...|..
Mouse    48 PDISVSLLTLVVTACGLALFGVSLFVSWKLCWVPWRERGLFSGSKDNNQE----PLNYTDTETNE 108

  Fly    65 RSPSG---QPPHYLKKSPSPTGGKQMGLLSPMQDQSTSPIAQPNVKYS-------EEGDGPAQH- 118
            :..|.   .||     :|.|....::...||....||.|..|.|..::       .|....|:|
Mouse   109 QENSEDFLDPP-----TPCPDSSMKISHTSPDIPLSTQPGGQENCAHAVRVQRQVTEPTPSARHN 168

  Fly   119 ---------------AEQQNGNQLTVVDGNG-LKHSLHNSLHHSPVETIANGSVTITLDDHSLTN 167
                           .:.|...|||   |.| :|..|:..      .::.|       ||...:|
Mouse   169 SIRRQLNLSNPDFNIQQLQRQEQLT---GIGRIKPELYKQ------RSLDN-------DDGRRSN 217

  Fly   168 GKELTVTDQYGKLGTIYFKLRYLAERNALMVSIIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDP 232
            .|..      |||.   |.|:|..:...|:|.|.:...||.| ..|||              :||
Mouse   218 SKAC------GKLN---FILKYDCDLEQLIVKIHKAVNLPAK-DFSGT--------------SDP 258

  Fly   233 YVKLQLLPDKQHKVKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEV 297
            |||:.||||::.|.:|:|.|.|.|||:||.|.| .::.|||:...|||.:..|||:||.|:||:|
Mouse   259 YVKIYLLPDRKTKHQTKVHRKTLNPVFDEVFLF-PVHYNDLEARKLHFSVYDFDRFSRHDLIGQV 322

  Fly   298 VCPLTSIEIGDISKEALSISKEIQ---PRSLKIRAQGRGELLISLCWQPAAGRLTVVLLKARNLP 359
            |.. ...::.|..:|.: :.|:|:   ..::.:     |||:.|||:.|.|||||:.::|||||.
Mouse   323 VVD-HFFDLADFPRECI-LWKDIEYVTNDNVDL-----GELMFSLCYLPTAGRLTITIIKARNLK 380

  Fly   360 RMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAFDIPAAEGAGASLEGVSLELM 424
            .||:||.:|||||:.|:.:|:|:.|:||..|:.||:||:||:..||:|.     .|::.:.|.:.
Mouse   381 AMDITGASDPYVKVSLMCDGRRLKKRKTSTKRNTLNPVYNEAIVFDVPP-----ESIDQIHLSIA 440

  Fly   425 LLDWDRVTKNEVIGRLELGGPNSSSTALNHWNEVCNSPRRQIAEWHKLNE 474
            ::|:|||..|||||..::|. .:.....:||:|:.:.||:.||.||.|.|
Mouse   441 VMDYDRVGHNEVIGVCQVGN-EAERLGRDHWSEMLSYPRKPIAHWHSLME 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	55/145 (38%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	63/140 (45%)
Syt9	NP_068689.2	Cysteine motif. /evidence=ECO:0000250\|UniProtKB:O35681	9..31
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..147		16/64 (25%)
		C2	221..345	CDD:387358	56/150 (37%)
		C2B_Synaptotagmin-3-5-6-9-10	354..487	CDD:176048	63/138 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820