DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt4 and sytl5

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_686619.6	Gene:	sytl5 / 558324	ZFINID:	ZDB-GENE-070912-424	Length:	692	Species:	Danio rerio

Alignment Length:	517	Identity:	121/517 - (23%)
Similarity:	198/517 - (38%)	Gaps:	138/517 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 RRPTAVRSPSGQP--PHYLK----KSPSPTGGKQMGLLSPMQDQSTSPIAQPNVKYSEEGDGPAQ 117
            :|..|| .|||.|  |:.::    |:|:.|..:.    .|...:|.|.|...:....:..||..|
Zfish   187 KRAVAV-EPSGLPTVPNNMRAQMAKTPTQTEARN----RPDGAESVSSIQSSDSVPEKMADGRRQ 246

  Fly   118 -----------HAEQQNGNQLTVVD----GNGLKH--------------------------SLH- 140
                       .|...:....:.||    |.||..                          |.|
Zfish   247 TDSSTPSIAVSRASLSSDRSRSEVDLSNPGEGLSEDPLISRCRSVPGLNDGDSDEDIDAVLSAHY 311

  Fly   141 ---------NSLHHSPVETIANGSVTITLDDHSLTNGKEL----TVTDQYGKL---GTIYFKLRY 189
                     .|:..:|......|.:.:...|...|:...|    :.|..||.:   |.|...:.|
Zfish   312 KTNRSVCSAQSMSSTPASERKWGFLNVPDSDADTTSINSLMSVYSETGDYGSVRVSGEILLNISY 376

  Fly   190 LAERNALMVSIIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDK--QHKVKTRVVR 252
            ..:..||.|.:..||.|       .|||       ..:..||.|||..|||||  |.|.||.:..
Zfish   377 SYKTGALNVLVRECRCL-------ATGD-------ERRQRTDAYVKTYLLPDKSRQSKRKTSIKS 427

  Fly   253 NTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKEALSIS 317
            |:.|||::|:.. |.::.:.|:..:|...:...||:..::.:||......|.|.....:|..::.
Zfish   428 NSTNPVFNENLR-YVVSHSQLETRTLQVSVWHHDRFGHNNFLGETELTFDSWEFDTQIEEWFALQ 491

  Fly   318 KEIQPRSLKIRAQGRGELLISLCWQPA-----------------------------AGRLTVVLL 353
            ..|:...:......:|||.:.|.:.||                             .|.:.:::.
Zfish   492 PRIESDYVDSVMHYKGELTVVLKYIPAERNVSLPLDQVQVKKGFLKGKKKTITLPKGGMVELLVK 556

  Fly   354 KARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAFDIPAAEGAG---AS 415
            :|:||..:. .|.:||:||.|||.:.::..|.||.|.||:::|.:|.:|.:       .|   :.
Zfish   557 EAKNLTAVK-GGSSDPFVKGYLLPDDKKSTKHKTAVVKRSVNPRWNHTFTY-------CGLQHSD 613

  Fly   416 LEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNH-----WNEVCNSPRRQIAEWHKL 472
            |:.|.|||.:.|.:....|..:|.:.||    :.|.|::     ||:.....:|.   |.::
Zfish   614 LDSVCLELTVWDREPFASNVFLGGVRLG----AGTGLSYGKEVDWNDAYGEEQRL---WQRM 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	42/147 (29%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	44/178 (25%)
sytl5	XP_686619.6	PHD_SF	13..124	CDD:304600
		C2A_SLP-4_5	367..491	CDD:175995	41/138 (30%)
		C2B_SLP_1-2-3-4	506..683	CDD:175987	44/178 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810