DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt4 and syt13

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_017212345.2	Gene:	syt13 / 550345	ZFINID:	ZDB-GENE-050417-135	Length:	530	Species:	Danio rerio

Alignment Length:	481	Identity:	116/481 - (24%)
Similarity:	197/481 - (40%)	Gaps:	95/481 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AILGLTAAAVLSSVACICARQMRLRNKKQSQHDASFPFQPTR-RPTAVRSPSGQPPHYLKKSPSP 81
            |:||.|...| |.|..:|...:..::.|:.:.::.....|.: :|:.:.:.:....|...:...|
Zfish   117 ALLGATLGTV-SGVLTLCGLSLLCKSCKKGKLESGDEADPEKAKPSILHTLTQFSVHKCTEPIQP 180

  Fly    82 TGGKQMGLLSP-MQDQSTSPIAQPNVKYSEEG-DGPAQHAEQQNGNQLTVVDGNGLKHSL--HNS 142
                |..|..| :.....|..:|..:.|.|.| ......||....||.|..:.   ..||  ..|
Zfish   181 ----QASLKFPQIYRPKPSVTSQEVINYKEHGASNDTSAAELDTCNQATEREE---VFSLPRQAS 238

  Fly   143 LHHSPVETIANGSVTITLDDHSLTNGKELTVTDQYGKLGTIYFKLRYLAERNALMVSIIRCRGLP 207
            ....|..:...|::|        |:...|     |.||   :|.:....|...|.::|:....:.
Zfish   239 ADEIPCSSEQTGAMT--------TSSSIL-----YPKL---HFSISLHKESGELHINIVEAENIS 287

  Fly   208 CKGGSSGTGDIPTGMNGRTQAATDPYVK-LQLLPDKQHKVKTRVVRNTRNPVYDEDFTFYGLNMN 271
            .:.|..|                  |:. ...:.::|....|.|.:...:..:.|:..| .|.|.
Zfish   288 VEAGCEG------------------YISGCVSVSEEQKHAHTAVHKLAVHVQWGEELVF-ALPME 333

  Fly   272 DLQN---------MSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKEALSISK----EIQPR 323
            ..::         :|||    ..||:|.:..:|     :...::.|:|   :.:..    ::||.
Zfish   334 STEDTDSLDGEVALSLH----CCDRFSHNSTLG-----MMRFKLADVS---MMLDADCWVDLQPP 386

  Fly   324 SLKIRAQGRGELLISLCWQPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTH 388
            ..:: ....||||:||.:.|||.||.||::|||.|....:....|..||:.|.:...::.||:|.
Zfish   387 KQEV-TSSTGELLLSLSYLPAANRLGVVVMKARGLQSDKLKDNIDLSVKLTLKHQNAKLKKKQTR 450

  Fly   389 VKKRTLSPVFNESFAFDIPAAEGAGASLEGVSLELM-------LLDWDRVTKNEVIGRLELGGPN 446
            ..|..::||:||....::|:...|.:|   |.||::       ||.         :||..| |..
Zfish   451 RVKHKMNPVWNEMMMLELPSELLAKSS---VDLEVLNLASPGTLLP---------LGRCML-GLQ 502

  Fly   447 SSSTALNHWNEVCNSPRRQIAEWHKL 472
            :|.|.|.||.::.::||:|||.||.|
Zfish   503 TSGTGLQHWKQMLDNPRKQIAMWHPL 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	25/156 (16%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	54/148 (36%)
syt13	XP_017212345.2	C2A_Synaptotagmin-13	261..383	CDD:176059	25/155 (16%)
syt13	XP_017212345.2	C2B_Synaptotagmin-13	394..529	CDD:176052	54/148 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020