DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt4 and SYTL2

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_996810.2	Gene:	SYTL2 / 54843	HGNCID:	15585	Length:	2239	Species:	Homo sapiens

Alignment Length:	467	Identity:	111/467 - (23%)
Similarity:	204/467 - (43%)	Gaps:	56/467 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VLSSVACICARQMRLRNKKQSQHDASFPFQPTRRP-TAVRSPSGQPPHYLKKSPSPTGGKQMGLL 90
            ||.::....||:|..::.:....|:|...:...:| ..|||.....    |....|...:.:..:
Human  1784 VLKTLERSAARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAEDDE----KPDQKPVTNECVPRI 1844

  Fly    91 SPMQDQSTSPIAQPNVKYSEEGDGPAQHAEQQNGNQLTVVDGNGLKHSLHNSLHHSPVETIANGS 155
            |.:..|..:|.:.|:.........||...::.:..:......:..:.|.|..   || .::.|.|
Human  1845 STVPTQPDNPFSHPDKLKRMSKSVPAFLQDESDDRETDTASESSYQLSRHKK---SP-SSLTNLS 1905

  Fly   156 VTITLDDHSLTNGKELTV-TDQYGKL---GTIYFKLRYLAERNALMVSIIRCRGLPCKGGSSGTG 216
            .:..:...|..:|..::| :..:|.|   |.|.|.:.|:.....|.|.:.:|:.|       ...
Human  1906 SSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDL-------AAA 1963

  Fly   217 DIPTGMNGRTQAATDPYVKLQLLPD--KQHKVKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLH 279
            |:       .:..:|||||..||||  |..|.||.||:.|.||||:| ...|.:....|:...|:
Human  1964 DV-------KKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNE-ILRYKIEKQILKTQKLN 2020

  Fly   280 FVILSFDRYSRDDVIGEVVCPLTSIEIGDISKEAL---SISKEIQPRSLKIRAQGRGELLISLCW 341
            ..|...|.:.|:..:|||...|.:.:..:...:.|   .:.::..|.:|:  |:.|||:.::|.:
Human  2021 LSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALE--AENRGEMKLALQY 2083

  Fly   342 ---------QPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPV 397
                     .|..|.:.:.:.:..:||.:..:.| :.:||..:|.:..|.:::||....:|.:|:
Human  2084 VPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHL-NSFVKCTILPDTSRKSRQKTRAVGKTTNPI 2147

  Fly   398 FNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNHWNEV--CN 460
            ||.:..:|....|    .|....:||.:.|..::| |:.:|.|.:|    ..|..::..||  .:
Human  2148 FNHTMVYDGFRPE----DLMEACVELTVWDHYKLT-NQFLGGLRIG----FGTGKSYGTEVDWMD 2203

  Fly   461 SPRRQIAEWHKL 472
            |...::|.|.|:
Human  2204 STSEEVALWEKM 2215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	42/150 (28%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	37/152 (24%)
SYTL2	NP_996810.2	PHD_SF	5..>41	CDD:328929
		C2	1934..2061	CDD:326325	41/141 (29%)
		C2B_SLP_1-2-3-4	2074..2230	CDD:175987	37/152 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910