DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt4 and Syt10

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_061273.1	Gene:	Syt10 / 54526	MGIID:	1859546	Length:	523	Species:	Mus musculus

Alignment Length:	419	Identity:	143/419 - (34%)
Similarity:	211/419 - (50%)	Gaps:	74/419 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 QDQSTSPIA-QPNVKYSEEGDGPAQHAEQQNGNQLTVVDGNGLKH-------------SLHNSLH 144
            :::..:|.| :|.:|.|.  ..|...||.|     |.:..:.:||             |.|||..
Mouse   118 ENEKPAPKAIEPAIKISH--TSPDIPAEVQ-----TALKEHLIKHARVQRQTTEPTSSSRHNSFR 175

  Fly   145 HSPVETIANGSVTITLDDHSLTNGKELTVT---------------------DQYGKLGTIYFKLR 188
            ......:...||..::....:....|...:                     |.....|.:.|.|:
Mouse   176 RHLPRQMNVSSVDFSVGTEPILQRGETRTSIGRIKPELYKQKSVDSEGNRKDDVKTCGKLNFALQ 240

  Fly   189 YLAERNALMVSIIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVVRN 253
            |..|...|:|.||:...||.| ..:||              :|||||:.||||::.|.:|||.|.
Mouse   241 YDYENELLVVKIIKALDLPAK-DFTGT--------------SDPYVKIYLLPDRKKKFQTRVHRK 290

  Fly   254 TRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKEALSISK 318
            |.||::||.|.| .:..:.|.|..|||.|..|||:||.|:||||:.. ...|:.|:|:|| ::.|
Mouse   291 TLNPLFDELFQF-PVVYDQLSNRKLHFSIYDFDRFSRHDMIGEVILD-NLFEVSDLSREA-TVWK 352

  Fly   319 EIQ---PRSLKIRAQGRGELLISLCWQPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQ 380
            :|.   ..|:.:     ||::.|||:.|.|||:|:.::|.|||..||:||.:|||||:.|:..|:
Mouse   353 DIHCATTESIDL-----GEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGR 412

  Fly   381 RIAKKKTHVKKRTLSPVFNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGP 445
            |:.|:||..||.||:||:||:..||||.     .:::.|||.:.::|:|||..|||||.... |.
Mouse   413 RLKKRKTTTKKNTLNPVYNEAIIFDIPP-----ENVDQVSLCIAVMDYDRVGHNEVIGVCRT-GL 471

  Fly   446 NSSSTALNHWNEVCNSPRRQIAEWHKLNE 474
            ::.....:||||:....|:.|..||.|.|
Mouse   472 DAEGLGRDHWNEMLAYHRKPITHWHPLLE 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	58/145 (40%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	62/140 (44%)
Syt10	NP_061273.1	Cysteine motif. /evidence=ECO:0000250\|UniProtKB:O35681	13..35
		C2A_Synaptotagmin-1-5-6-9-10	231..356	CDD:176031	58/142 (41%)
		C2B_Synaptotagmin-3-5-6-9-10	365..498	CDD:176048	62/138 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820