DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt4 and Syt7

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_030106854.1	Gene:	Syt7 / 54525	MGIID:	1859545	Length:	719	Species:	Mus musculus

Alignment Length:	397	Identity:	132/397 - (33%)
Similarity:	214/397 - (53%)	Gaps:	74/397 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 PTGGKQMGLLSPMQDQSTSPIAQPNVKYSEEGDGPAQHAEQQNGNQLTVVDGNGLKHSLHNSLHH 145
            |.|||.:         :|:|:         .|..|...::::...:.:|.|       |.||| .
Mouse   390 PAGGKAV---------NTAPV---------PGQTPHDESDRRTETRSSVSD-------LVNSL-T 428

  Fly   146 SPVETIANGSVTITLDDHSLTNG--KELTVTDQYGKLGTIYFKLRYLAERNALMVSIIRCRGLPC 208
            |.:..::.||     ::.....|  :|        .||.|.|.:.|..:.:.|.|.:::.:.||.
Mouse   429 SEMLMLSPGS-----EEDEAHEGCSRE--------NLGRIQFSVGYNFQESTLTVKVMKAQELPA 480

  Fly   209 KGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVVRNTRNPVYDEDFTFYGLNMNDL 273
            | ..|||              :||:||:.|||||:||::|:|.|...||.::|.|.|.|.....:
Mouse   481 K-DFSGT--------------SDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPYEKV 530

  Fly   274 QNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKEALSISKEIQPRSLKIRAQGRGELLIS 338
            ....|:..:|.:||:||:|.||||..||..:::..:.    :..|:::|.|  ..:..|||||:|
Mouse   531 VQRVLYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQ----TFWKDLKPCS--DGSGSRGELLLS 589

  Fly   339 LCWQPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFA 403
            ||:.|:|..:.|.::|||||..||:.|.:|||||::|:|..:|:.||||..|||.|:|:||||||
Mouse   590 LCYNPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTKKRNLNPIFNESFA 654

  Fly   404 FDIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLEL---GGPNSSSTALNHWNEVCNSPRRQ 465
            ||||..:     |...::.:.::|.|::::|:|||::.|   .||..    :.||.::...||:.
Mouse   655 FDIPTEK-----LRETTIIITVMDKDKLSRNDVIGKIYLSWKSGPGE----VKHWKDMIARPRQP 710

  Fly   466 IAEWHKL 472
            :|:||:|
Mouse   711 VAQWHQL 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	47/142 (33%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	64/144 (44%)
Syt7	XP_030106854.1	PHA03307	138..>343	CDD:223039
		C2A_Synaptotagmin-7	451..575	CDD:176032	47/142 (33%)
		C2B_Synaptotagmin-7	583..718	CDD:176050	64/144 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820