DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt4 and Syt5

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_062223.1	Gene:	Syt5 / 54309	RGDID:	3806	Length:	386	Species:	Rattus norvegicus

Alignment Length:	481	Identity:	147/481 - (30%)
Similarity:	224/481 - (46%)	Gaps:	128/481 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AEEYIPDAS-VMDTIVPA------ILGLTAAAVLSSVACICARQMRLRNKKQSQHDASFPFQPTR 59
            |.|..||:| :....|||      :|| :...|.||..|:..::.|.|..|:||..|....|..
  Rat    12 APETPPDSSRIRQGAVPAWVLATILLG-SGLLVFSSCFCLYRKRCRRRMGKKSQAQAQVHLQEV- 74

  Fly    60 RPTAVRSPSGQPPHYLKKSPSPTGGKQMGLLSPMQDQSTSPIAQPNVKYSEEGD-GPAQHAEQQN 123
                                     |::|       :|.....||.:   ||.| .|:...:|
  Rat    75 -------------------------KELG-------RSYIDKVQPEI---EELDPSPSMPGQQ-- 102

  Fly   124 GNQLTVVDGNGLKHSLHNSLHHSPVETIANGSVTITLDDHSLTNGKELTVTDQYGKLGTIYFKLR 188
                                               .||.|               :||.:.:.|.
  Rat   103 -----------------------------------VLDKH---------------QLGRLQYSLD 117

  Fly   189 YLAERNALMVSIIRCRGLPC--KGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVV 251
            |..:...|:|.|::..||..  .||||                 ||||.:.|||||:.:.:|:|.
  Rat   118 YDFQTGQLLVGILQAEGLAALDLGGSS-----------------DPYVSVYLLPDKRRRHETKVH 165

  Fly   252 RNTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKEALSI 316
            |.|.||.:.|.|.| .:...:|....|...:..|||:||:|.||||..|::|:.:|    ..:..
  Rat   166 RQTLNPHFGETFAF-KVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVNLG----RPVQA 225

  Fly   317 SKEIQPRSLKIRAQGRGELLISLCWQPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQR 381
            .:|:|. :.|...:..|::..||.:.|.||:|||::|:|:||.:|||.||:|||||::||..|::
  Rat   226 WRELQV-APKEEQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKK 289

  Fly   382 IAKKKTHVKKRTLSPVFNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPN 446
            :.||||.:||.||:|.:||:|:|::|..:     ::.|.:||.:||:|::.|||.|||:.: |..
  Rat   290 VRKKKTTIKKNTLNPYYNEAFSFEVPCDQ-----VQKVQVELTVLDYDKLGKNEAIGRVAV-GTA 348

  Fly   447 SSSTALNHWNEVCNSPRRQIAEWHKL 472
            .....|.||.::..:|||.||:||.|
  Rat   349 VGGAGLRHWADMLANPRRPIAQWHSL 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	47/144 (33%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	64/141 (45%)
Syt5	NP_062223.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		4/8 (50%)
		Syt1_2_N	6..76	CDD:425364	21/90 (23%)
		C2A_Synaptotagmin-1-5-6-9-10	108..230	CDD:176031	47/143 (33%)
		C2B_Synaptotagmin-1	240..374	CDD:176047	63/139 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820