DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt4 and Sytl3

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_006227950.1	Gene:	Sytl3 / 499017	RGDID:	1561992	Length:	609	Species:	Rattus norvegicus

Alignment Length:	501	Identity:	127/501 - (25%)
Similarity:	194/501 - (38%)	Gaps:	120/501 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RLRNKKQSQHDASFPFQPTRRPTAVRSPSGQPPHYLKKSPSPTG------------GKQMGLLSP 92
            ||....|.|........||..|.: .|..|..|:.|::.....|            ..||..||.
  Rat   140 RLLQSYQRQSSKISVVPPTPPPLS-ESQCGGSPNRLQELGHFRGFNKSVENLFLSVTTQMRKLSK 203

  Fly    93 MQDQSTSPIAQPNVKYSEEGDGPAQ---HAEQQNGNQLTVVDGNGLKHSLHNSL--------HH- 145
            .|:..||.      |:....| |.|   |.|:::.:. |.|:....|.|..:.|        .|
  Rat   204 SQNDMTSE------KHLLAMD-PRQCMGHTERRSQSD-TAVNVTSRKTSTPDILKAFHQEDPRHP 260

  Fly   146 -SPV---ETIANGSVTITLDDHSLTNGKELTVT---------DQYGKLGTIYFKLRYLAERNALM 197
             |||   :|..:.....|:....|.:|..::|.         |.....|.|.|.:.|....::|.
  Rat   261 PSPVLKQDTPPSSPTHSTVFSGGLRHGSLISVNSTCTEMGNFDNANVTGEIEFAIHYCVNSHSLE 325

  Fly   198 VSIIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDK--QHKVKTRVVRNTRNPVYD 260
            :.|..|:.|            ..|.:.|.:.  :||||..||||:  |.|.||||.:||.:|.::
  Rat   326 ICIKTCKNL------------AYGEDKRRKC--NPYVKTYLLPDRSSQGKRKTRVQKNTLDPTFE 376

  Fly   261 EDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEI-GDISKEALSISKEIQPRS 324
            |... |.::...|....|...:......:|...:|||:.||.:.:. |..::.|         |.
  Rat   377 ETLK-YQVDPAQLATRRLQVSVWHLGTLARRVFLGEVILPLATWDFEGSAAQNA---------RW 431

  Fly   325 LKIRA----------QGRGELLISL---------CWQPAA-------GRLTVVLLKARNLP-RMD 362
            ..:||          |..|||.:..         ..|.|.       |:|.:|:|.|:||| |.|
  Rat   432 YPLRAKAEKYEENIPQTNGELAVRAKLVLPVGPRMLQEAQEDQLALNGQLCLVVLGAKNLPVRSD 496

  Fly   363 VTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAFDIPAAEGAGAS-LEGVSLELMLL 426
              |..:.:||..|....|:..:.|:.|.|:...|.:..||.|:     |..:| |...:|||.:
  Rat   497 --GTLNSFVKGCLTLPDQQKLRVKSPVLKKQACPQWKHSFVFN-----GVSSSQLRQSTLELTV- 553

  Fly   427 DWDRV---TKNEVIGRLELGG-------PNSSSTALNHWNEVCNSP 462
             ||:.   ..:.::|..:||.       .:|.|.:...|.:|.:||
  Rat   554 -WDQAMFGMNDRLLGEAKLGSKGGAPGCTDSCSQSKLQWQKVLSSP 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	39/145 (27%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	44/159 (28%)
Sytl3	XP_006227950.1	PHD_SF	14..123	CDD:419867
		FYVE_like_SF	60..108	CDD:333710
		C2	308..435	CDD:417471	40/150 (27%)
		C2B_SLP_1-2-3-4	449..609	CDD:175987	44/159 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810