Protein Alignment Syt4 and Sytl2

DIOPT Version :10

• Sequence 1: NP_477464.1
• Gene: Syt4 / 40876
• FlyBaseID: FBgn0028400
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_001101962.2
• Gene: Sytl2 / 361604
• RGDID: 1307647
• Length: 2155
• Species: Rattus norvegicus
• Alignment Length: 447
• Identity: 103/447 - (23%)
• Similarity: 178/447 - (39%)
• Gaps: 112/447 - (25%)

  Fly    52 SFPFQPTRRPTAVRSPSGQPPHYLKKSPSPTGGKQMGLLSPMQDQSTSPIAQPNVKYSEEGDGPA 116
            |.|..|...|..::..|...|.:|                  ||:|.          ..|.|..:
  Rat  1765 SLPDNPFSHPDKLKRMSKSVPAFL------------------QDESD----------DRETDTAS 1801

  Fly   117 QHAEQ-----QNGNQLTVVDGNGLKHSLHNSLHHSPVETIANGSVTITLDDHSLTNGKELTVTDQ 176
            :.:.|     ::.:.||.:..:....||.:          |:|||.      |:.:|       .
  Rat  1802 ESSYQLRRYKKSPSSLTNLSSSSGMTSLSS----------ASGSVM------SVYSG-------D 1843

  Fly   177 YGKL---GTIYFKLRYLAERNALMVSIIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVKLQL 238
            :|.|   |::.|.:.|:.....|.|.:.:|:.|......              :..:|||||..|
  Rat  1844 FGNLEVKGSVQFAIDYVESLKELHVFVAQCKDLAAADAK--------------KQRSDPYVKTYL 1894

  Fly   239 LPD--KQHKVKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPL 301
            |||  |..|.||.||:.|.||||:| ...|.:....|:...|:..:...|.:.|:..:|||...|
  Rat  1895 LPDKGKMGKKKTLVVKKTLNPVYNE-ILRYKIERQVLKTQKLNLSVWHRDTFKRNSFLGEVELDL 1958

  Fly   302 TSIEIGDISKEALS---ISKEIQPRSLKIRAQGRGELLISLCW---------QPAAGRLTVVLLK 354
            .:.:......:.|.   :.::..|.:|:  .:.|||:.::|.:         .|..|.:.:.:.:
  Rat  1959 ETWDWDSKQNKQLKWYPLKRKTAPVALE--TENRGEMKLALQYVPEPSPGKKLPTTGEVHIWVKE 2021

  Fly   355 ARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAFDIPAAEGAGASLEGV 419
            ..:||.:..:.| :.:||..:|.:..|.:::||....:|.:||||.:..:|....|    .|...
  Rat  2022 CLDLPLLRGSHL-NSFVKCTILPDTSRKSRQKTRAVGKTSNPVFNHTMVYDGFRPE----DLMEA 2081

  Fly   420 SLELMLLDWDRVTKNEVIGRLELG--------------GPNSSSTALNHWNEVCNSP 462
            .:||.:.|..::| |:.:|.|.:|              ...|...||  |.::.|||
  Rat  2082 CVELTVWDHYKLT-NQFLGGLRIGFGTGKSYGTEVDWMDSTSEEAAL--WEKMVNSP 2135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	39/150 (26%)
		C2B_Synaptotagmin-4	332..473	CDD:176049	38/154 (25%)
Sytl2	NP_001101962.2	PHD_SF	5..>51	CDD:473978
		rad2	<197..>425	CDD:273166
		PTZ00108	<1592..1812	CDD:240271	13/74 (18%)
		C2A_SLP-1_2	1850..1977	CDD:176039	38/141 (27%)
		C2B_SLP_1-2-3-4	1990..2146	CDD:175987	38/154 (25%)