DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt4 and Rph

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster

Alignment Length:	499	Identity:	114/499 - (22%)
Similarity:	191/499 - (38%)	Gaps:	122/499 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 RSPSGQPPHYLKKSPSPTGGKQMGLLSPMQDQSTSP-----IAQPNVKYSEEGDGPAQHAEQQN- 123
            ||.|..|      .|:|..|...|....:|....:|     :.:..::.::.....:.|:|.::
  Fly   164 RSASATP------IPNPGPGSMAGDTRAVQSCHATPTRPARVKKLTIRVNDSSSSSSGHSEPEDE 222

  Fly   124 -----GNQLTVVDG-----------------------------NGLKHSLHNSLHHS------PV 148
                 |..:.||.|                             :|.:..|.||...:      |.
  Fly   223 VDTGVGIGVGVVGGGMAKGIASTRLQREDSFRLRAYGSIRSFIDGGERKLSNSFFFNRQQSQRPS 287

  Fly   149 ET-----------------IANGSVTI--TLDDHS---LTNGKELTVTDQYGK------------ 179
            |.                 :..|||:.  ::.|.|   ..|........||.:
  Fly   288 ECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQHCRDP 352

  Fly   180 -LGTIYFKLRYLAERNALMVSIIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQ 243
             ||.:...:.|....::|..:::|.|.||....:               ...|||.||.::..:.
  Fly   353 LLGWLEIAISYREAFHSLDCTMVRARDLPAMDAA---------------GLADPYCKLNIITPEA 402

  Fly   244 HK-----VKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTS 303
            |.     .:|:.|..||||.::|...|.|:...:|.|..::..:...|:|..|.:....|| |::
  Fly   403 HTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGHDFLGAAKVC-LST 466

  Fly   304 IEIGDISKEALSISKEIQPRSLKIRAQG--RGELLISLCWQPAAGRLTVVLLKARNLPRMDVTGL 366
            :......:.::.:..|.|..:....||.  .|::|:|||:......|.|.:.:..||..||..|.
  Fly   467 VHSTSQYRISVPLGVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGS 531

  Fly   367 ADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAFDIPAAEGAGASLEGVSLELMLLD-WDR 430
            :||:|||.|..:..:..|.||.||.|||:|::||.|.|:        ||...::.|:::|. ||:
  Fly   532 SDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFE--------ASPHDLNKEMLILTVWDK 588

  Fly   431 --VTKNEVIGRLELGGPNSSSTALNHWNEVCNSPRRQIAEWHKL 472
              ...|:.:|.|:||. .|....|..|.:....|.....:||.|
  Fly   589 DLGKSNDFLGSLQLGA-QSKGERLQQWLDCIRLPDHFHEKWHCL 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	32/160 (20%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	49/144 (34%)
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600	4/13 (31%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	31/138 (22%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	47/140 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468148
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		mtm1065
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840