Protein Alignment Syt4 and Rph

DIOPT Version :10

• Sequence 1: NP_477464.1
• Gene: Syt4 / 40876
• FlyBaseID: FBgn0028400
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Alignment Length: 499
• Identity: 114/499 - (22%)
• Similarity: 191/499 - (38%)
• Gaps: 122/499 - (24%)

  Fly    65 RSPSGQPPHYLKKSPSPTGGKQMGLLSPMQDQSTSP-----IAQPNVKYSEEGDGPAQHAEQQN- 123
            ||.|..|      .|:|..|...|....:|....:|     :.:..::.::.....:.|:|.::
  Fly   164 RSASATP------IPNPGPGSMAGDTRAVQSCHATPTRPARVKKLTIRVNDSSSSSSGHSEPEDE 222

  Fly   124 -----GNQLTVVDG-----------------------------NGLKHSLHNSLHHS------PV 148
                 |..:.||.|                             :|.:..|.||...:      |.
  Fly   223 VDTGVGIGVGVVGGGMAKGIASTRLQREDSFRLRAYGSIRSFIDGGERKLSNSFFFNRQQSQRPS 287

  Fly   149 ET-----------------IANGSVTI--TLDDHS---LTNGKELTVTDQYGK------------ 179
            |.                 :..|||:.  ::.|.|   ..|........||.:
  Fly   288 ECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQHCRDP 352

  Fly   180 -LGTIYFKLRYLAERNALMVSIIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQ 243
             ||.:...:.|....::|..:::|.|.||....:               ...|||.||.::..:.
  Fly   353 LLGWLEIAISYREAFHSLDCTMVRARDLPAMDAA---------------GLADPYCKLNIITPEA 402

  Fly   244 HK-----VKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTS 303
            |.     .:|:.|..||||.::|...|.|:...:|.|..::..:...|:|..|.:....|| |::
  Fly   403 HTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGHDFLGAAKVC-LST 466

  Fly   304 IEIGDISKEALSISKEIQPRSLKIRAQG--RGELLISLCWQPAAGRLTVVLLKARNLPRMDVTGL 366
            :......:.::.:..|.|..:....||.  .|::|:|||:......|.|.:.:..||..||..|.
  Fly   467 VHSTSQYRISVPLGVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGS 531

  Fly   367 ADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAFDIPAAEGAGASLEGVSLELMLLD-WDR 430
            :||:|||.|..:..:..|.||.||.|||:|::||.|.|:        ||...::.|:::|. ||:
  Fly   532 SDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFE--------ASPHDLNKEMLILTVWDK 588

  Fly   431 --VTKNEVIGRLELGGPNSSSTALNHWNEVCNSPRRQIAEWHKL 472
              ...|:.:|.|:||. .|....|..|.:....|.....:||.|
  Fly   589 DLGKSNDFLGSLQLGA-QSKGERLQQWLDCIRLPDHFHEKWHCL 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	32/160 (20%)
		C2B_Synaptotagmin-4	332..473	CDD:176049	49/144 (34%)
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	4/13 (31%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	31/138 (22%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	47/140 (34%)